Abstract: Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.

Abstract: A method of forming a prosthetic tooth element (104) is disclosed, the method comprising depositing a first hardenable fluid material (101) at a bottom of a cavity (111) of a female mould (110) to a first level (113), the first material having a first translucency when hardened; depositing in the cavity (111), over the first material (101), a second hardenable fluid material (102) to a second level (114), the second material having a second translucency when hardened, the second translucency being less translucent than the first translucency; and inserting a male mould (120) into the cavity (111), the insertion of the male mould displacing at least a portion of the second material (102) within the cavity (111).

Abstract: A method of forming a prosthetic tooth element (104) is disclosed, the method comprising depositing a first hardenable fluid material (101) at a bottom of a cavity (111) of a female mould (110) to a first level (113) , the first material having a first translucency when hardened; depositing in the cavity (111), over the first material (101), a second hardenable fluid material (102) to a second level (114), the second material having a second translucency when hardened, the second translucency being less translucent than the first translucency; and inserting a male mould (120) into the cavity (111), the insertion of the male mould displacing at least a portion of the second material (102) within the cavity (111).

Abstract: A dental prosthesis is disclosed includes a prosthetic tooth element comprising ceramic and a veneer located on a surface of the prosthetic tooth element, the veneer comprising cured dental composite. The prosthetic tooth element can be fixed to a mount in a patient's mouth using the same dental composite used for the veneer. A method of forming a prosthetic tooth element is disclosed including filling a mould that is formed at least partially from flexible polymeric material with a dental mixture comprising ceramic, and applying pressure to the filled mould to form a prosthetic tooth element comprising ceramic with a roughened surface.

Abstract: A method of forming a plurality of compression moulds for moulding prosthetic tooth elements is disclosed. A natural tooth surface or a model of the natural tooth surface is scanned to obtain scan data. Based on the scan data, a first compression mould is formed comprising a first mould surface, the first mould surface having a shape corresponding to a shape of a natural tooth surface increased in size by a first scale factor. Based on the scan data, a second compression mould is formed comprising a second mould surface, the second mould surface having a shape corresponding to the shape of the natural tooth surface increased in size by a second scale factor, the second scale factor being different from the first scale factor. Prosthetic tooth elements and dental prostheses formed using the method are also disclosed.

Abstract: A dental prosthesis is disclosed includes a prosthetic tooth element comprising ceramic and a veneer located on a surface of the prosthetic tooth element, the veneer comprising cured dental composite. The prosthetic tooth element can be fixed to a mount in a patient's mouth using the same dental composite used for the veneer. A method of forming a prosthetic tooth element is disclosed including filling a mould that is formed at least partially from flexible polymeric material with a dental mixture comprising ceramic, and applying pressure to the filled mould to form a prosthetic tooth element comprising ceramic with a roughened surface.

Abstract: The disclosed fluid elements include radial blades extending to trailing edges and that are integral with front and rear shrouds to provide a fluid exit. Fillets adjoin the trailing edge and the front and rear shrouds at the exit. The front and rear shrouds respectively have first and second perimeter thicknesses at the impeller outer perimeter. The first perimeter thickness is greater than the second perimeter thickness at the trailing edge and adjacent to the exit, which provides greater high cycle fatigue in the area of the fillets.

Abstract: The disclosed fluid elements include radial blades extending to trailing edges and that are integral with front and rear shrouds to provide a fluid exit. Fillets adjoin the trailing edge and the front and rear shrouds at the exit. The front and rear shrouds respectively have first and second perimeter thicknesses at the impeller outer perimeter. The first perimeter thickness is greater than the second perimeter thickness at the trailing edge and adjacent to the exit, which provides greater high cycle fatigue in the area of the fillets.

Abstract: The present invention relates to tolerogenic dendritic cells (DCs) and methods for enriching for these cells in tissue preparations and using the cells for preventing or minimizing transplant rejection or for treating or preventing an autoimmune disease.

Abstract: A construction applicable to dental crowns, facings, inlays, and the like including a stainless steel wire mesh (3) shaped to fit closely over a prepared tooth remnant (1), and being integrally bonded to a cavity (11) of a crown body (4) so as to form an integral crown (5) ready for use. The integral crown (5) can be adhered to the remnant (1) in a conventional manner, for instance by using dental filler. The body (4) and mesh (3) are very strongly joined by a mechanical interlock action by virtue of the mesh texture.