Abstract: The present invention provides new prodrugs of therapeutically active compounds, including oligomeric prodrugs, and compositions to treat medical disorders, for example glaucoma, a disorder or abnormality related to an increase in intraocular pressure (IOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy.

Abstract: A multifunctional tool includes first and second handle members, first and second jaw members operatively connected to the first and second handle members and movable between a first open position and a second closed position, and first and second removable collar attachment members configured to be removably installed in the first and second jaw members, respectively, to provide different sizes of compressing and/or cutting diameters when the first and second jaw members are in the second closed position.

Abstract: A multifunctional tool includes first and second handle members, first and second jaw members operatively connected to the first and second handle members and movable between a first open position and a second closed position, and first and second removable collar attachment members configured to be removably installed in the first and second jaw members, respectively, to provide different sizes of compressing and/or cutting diameters when the first and second jaw members are in the second closed position.

Abstract: A multifunctional tool includes first and second handle members, first and second jaw members operatively connected to the first and second handle members and movable between a first open position and a second closed position, and first and second removable collar attachment members configured to be removably installed in the first and second jaw members, respectively, to provide different sizes of compressing and/or cutting diameters when the first and second jaw members are in the second closed position.

Abstract: A power generating system for operating below a surface of a body of water includes a fuel cell stack configured to react hydrogen and oxygen to produce electricity. An oxygen source is configured to provide oxygen to the fuel cell stack. A hydrogen source is configured to provide hydrogen to the fuel cell stack. The hydrogen source is at least partially submerged in water and incorporates a non-hydride metal alloy that reacts with water to produce hydrogen from the water.

Abstract: A multifunctional tool includes first and second handle members, first and second jaw members operatively connected to the first and second handle members and movable between a first open position and a second closed position, and first and second removable collar attachment members configured to be removably installed in the first and second jaw members, respectively, to provide different sizes of compressing and/or cutting diameters when the first and second jaw members are in the second closed position.

Abstract: A process for converting coal and other hydrocarbon solid fuel feedstocks comprises reacting the feedstock in a first stage exothermic hydropyrolysis reaction zone with a hydrogen-rich gas stream for producing methane. The methane from the first reaction zone is dissociated in a second endothermic reaction zone to produce solid carbon and hydrogen-rich gas using heat mainly from the first reaction zone. All heat to promote the desired extents of reaction in each reaction zone is provided solely from the exothermicity of chemical reactions in the process. The majority of the gas is recirculated from the second reaction zone to the first reaction zone. Hydrogen gas is recovered to produce electrical energy for reducing carbon dioxide emissions.

Abstract: A power generating system for operating below a surface of a body of water includes a fuel cell stack configured to react hydrogen and oxygen to produce electricity. An oxygen source is configured to provide oxygen to the fuel cell stack. A hydrogen source is configured to provide hydrogen to the fuel cell stack. The hydrogen source is at least partially submerged in water and incorporates a non-hydride metal alloy that reacts with water to produce hydrogen from the water.

Abstract: A hand tool comprising first and second jaw members and first and second handle members, the first handle and both jaw members being cooperatively connected by a force multiplying linkage system. A force applied to the first handle drives the linkage system to close the jaws to crimp or cut a work piece. In one embodiment of the invention, a link in the linkage system has a first end movable between first and second positions relative to its first end pivot pin wherein the first and second jaw members close a first distance when the link first end is in the first position and close a second distance when the link first end is in the second position. Other embodiments comprise other step-wise changes in distance between force-bearing pivot locations in the linkage system to close the jaws progressive distances with successive closures of the first and second handles.

Abstract: A hand tool comprising first and second jaw members and first and second handle members, the first handle and both jaw members being cooperatively connected by a force multiplying linkage system. A force applied to the first handle drives the linkage system to close the jaws to crimp or cut a work piece. In one embodiment of the invention, a link in the linkage system has a first end movable between first and second positions relative to its first end pivot pin wherein the first and second jaw members close a first distance when the link first end is in the first position and close a second distance when the link first end is in the second position. Other embodiments comprise other step-wise changes in distance between force-bearing pivot locations in the linkage system to close the jaws progressive distances with successive closures of the first and second handles.

Abstract: A hand tool comprising first and second jaw members and first and second handle members, the first handle and both jaw members being cooperatively connected by a force multiplying linkage system. A force applied to the first handle drives the linkage system to close the jaws to crimp or cut a work piece. In one embodiment of the invention, a link in the linkage system has a first end movable between first and second positions relative to its first end pivot pin wherein the first and second jaw members close a first distance when the link first end is in the first position and close a second distance when the link first end is in the second position. Other embodiments comprise other step-wise changes in distance between force-bearing pivot locations in the linkage system to close the jaws progressive distances with successive closures of the first and second handles.

Abstract: A pipe ring crimping tool providing significant mechanical advantage for applying force with a sufficient jaw opening and minimal external dimensions, minimal handle span and minimal handle length throughout the operational cycle. The tool is compact and lightweight to allow reach and access of the jaws into confined spaces. The tool utilizes a link and pin mechanism to translate the operator hand force exerted on the handles into a crimping force in a manner which allows for smooth application of operator hand force while increasing the crimping force as the pipe ring is compressed. The tool configuration by minimizing the handle spread, allows for single-handed operation of the tool or closely held two-handed operation. The tool includes a link mechanism designed to provide smooth crimping force and to preclude tool locking up and excess friction. The handles move laterally in opening the jaws to their maximum spread and are closed rotationally when crimping the pipe ring.