Patents by Inventor John G. Frelinger

John G. Frelinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease activated cytokines
    Patent number: 8734774
    Abstract: Provided herein are chimeric nucleic acid sequences encoding chimeric polypeptides. Also provided herein are chimeric polypeptides. Further provided herein are methods of treating a subject with or at risk of developing a cancer. The methods comprise selecting a subject with or at risk of developing a cancer, and administering to the subject an effective amount of the chimeric polypeptides provided herein.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: May 27, 2014
    Assignee: University of Rochester
    Inventors: John G. Frelinger, John Puskas, Baek Kim, Mark Sullivan
  • PROTEASE ACTIVATED CYTOKINES
    Publication number: 20130089516
    Abstract: Provided herein are chimeric nucleic acid sequences encoding chimeric polypeptides. Also provided herein are chimeric polypeptides. Further provided herein are methods of treating a subject with or at risk of developing a cancer. The methods comprise selecting a subject with or at risk of developing a cancer, and administering to the subject an effective amount of the chimeric polypeptides provided herein.
    Type: Application
    Filed: March 31, 2011
    Publication date: April 11, 2013
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: John G. Frelinger, John Puskas, Baek Kim, Mark Sullivan
  • Helper virus-free herpesvirus amplicon particles and uses thereof
    Patent number: 8119118
    Abstract: The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas (e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles (e.g., packaging cell lines or patients' cells, infected in vivo or ex vivo); particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.
    Type: Grant
    Filed: October 5, 2005
    Date of Patent: February 21, 2012
    Assignee: University of Rochester
    Inventors: Howard J. Federoff, William J. Bowers, John G. Frelinger, Richard A. Willis, Thomas G. Evans, Stephen Dewhurst, Khaled A. Tolba, Joseph D. Rosenblatt
  • HERPES SIMPLEX VIRUS AMPLICON VECTORS DERIVED FROM PRIMARY ISOLATES
    Publication number: 20110171257
    Abstract: Provided herein are HSV amplicon particles and methods of making and using HSV amplicon particles. The particles are generated using primary HSV isolates or packaging vectors derived from primary HSV isolates.
    Type: Application
    Filed: June 3, 2008
    Publication date: July 14, 2011
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Stephen Dewhurst, William J. Bowers, Howard J. Federoff, John G. Frelinger, Michael C. Keefer
  • Human glandular kallikrein (hk2)-specific monoclonal antibodies that enhance or inhibit the enzymatic activity of hk2
    Publication number: 20040219163
    Abstract: Disclosed are compositions and methods for preferentially binding hK2 over PSA.
    Type: Application
    Filed: May 27, 2004
    Publication date: November 4, 2004
    Inventors: John G. Frelinger, Terrence L. Fisher, Mary Ann Nocera, Edith M. Lord
  • Helper virus-free herpesvirus amplicon particles and uses thereof
    Publication number: 20030027322
    Abstract: The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas (e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles (e.g., packaging cell lines or patients'cells, infected in vivo or ex vivo); particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.
    Type: Application
    Filed: November 29, 2001
    Publication date: February 6, 2003
    Inventors: Howard J. Federoff, William J. Bowers, John G. Frelinger, Richard A. Willis, Thomas D. Evans, Stephen Dewhurst, Khaled A. Tolba, Joseph D. Rosenblatt
  • Prostate specific regulatory nucleic acid sequences and transgenic non-human animals expressing prostate specific antigen
    Patent number: 6100444
    Abstract: The non-coding regulatory sequences of the prostate specific antigen (PSA) are described. Non-human transgenic animals are also provided which express human PSA, which is non-naturally occurring in non-human animals.
    Type: Grant
    Filed: February 11, 1997
    Date of Patent: August 8, 2000
    Assignee: University of Rochester Medical Center
    Inventors: John G. Frelinger, Richard K. Barth, Chungwen Wei