Patents by Inventor John G. Hoey

John G. Hoey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • translocated substrate-1 (Ats-1) and sero-detection of
    Patent number: 9134324
    Abstract: Disclosed is the use of isolated Ats-1 protein in Anaplasma phagocytophilum in the ELISA detection of Anaplasma pathogen. The recombinant expression of Ats-1 and its use as a kit for ELISA are also disclosed.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: September 15, 2015
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: Denise P. Dimitrov, John G. Hoey
  • Hemolysin and its protein fragments in sero-detection of anaplasma phagocytophilum
    Patent number: 8859722
    Abstract: Disclosed is the cloning, expression and purification of a hemolysin protein and its protein fragments in Anaplasma phagocytophilum. The recombinant hemolysin and its protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as a kit for ELISA is also disclosed.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: October 14, 2014
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: John G. Hoey, Denise P. Dimitrov, Lisa P. Huang, Martin E. Adelson, Eli Mordechai
  • DETECTION KIT CONTAINING A NOVEL RECOMBINANT 15-kDA POLYPEPTIDE USEFUL FOR DETECTING HUMAN INFECTION WITH BARTONELLA HENSELAE
    Publication number: 20140141457
    Abstract: Disclosed are the cloning and expression of a novel antigen of Bartonella henselae. The recombinant polypeptide is found to be highly immunogenic and is useful as a diagnostic test antigen. The polypeptide of the present invention provides the basis of a diagnostic assay that is sensitive, rapid and accurate diagnosis of infection with Bartonella henselae using patient's sera. Disclosed also are the ELISA for both IgG and IgM and allows diagnosis of early and late infection.
    Type: Application
    Filed: October 8, 2013
    Publication date: May 22, 2014
    Applicant: MEDICAL DIAGNOSTIC LABORATORIES, LLC
    Inventors: John G. Hoey, Lisa P. Huang, Martin E. Adelson, Eli Mordechai
  • Detection kit containing a novel recombinant 15-kDA polypeptide useful for detecting human infection with
    Patent number: 8580271
    Abstract: Disclosed are the cloning and expression of a novel antigen of Bartonella henselae. The recombinant polypeptide is found to be highly immunogenic and is useful as a diagnostic test antigen. The polypeptide of the present invention provides the basis of a diagnostic assay that is sensitive, rapid and accurate diagnosis of infection with Bartonella henselae using patient's sera. Disclosed also are the ELISA for both IgG and IgM and allows diagnosis of early and late infection.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: November 12, 2013
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: John G. Hoey, Lisa P. Huang, Martin E. Adelson, Eli Mordechai
  • Anaplasma Translocated Substrate-1 (Ats-1) and Sero-detection of Anaplasma phagocytophilum
    Publication number: 20130295656
    Abstract: Disclosed is the use of isolated Ats-1 protein in Anaplasma phagocytophilum in the ELISA detection of Anaplasma pathogen. The recombinant expression of Ats-1 and its use as a kit for ELISA are also disclosed.
    Type: Application
    Filed: May 7, 2013
    Publication date: November 7, 2013
    Applicant: MEDICAL DIAGNOSTIC LABORATORIES
    Inventors: Denise P. Dimitrov, John G. Hoey
  • Hemolysin and its Protein Fragments in Sero-Detection of Anaplasma Phagocytophilum
    Publication number: 20130189715
    Abstract: Disclosed is the cloning, expression and purification of a hemolysin protein and its protein fragments in Anaplasma phagocytophilum. The recombinant hemolysin and its protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as a kit for ELISA is also disclosed.
    Type: Application
    Filed: July 30, 2012
    Publication date: July 25, 2013
    Applicant: MEDICAL DIAGNOSTIC LABORATORIES, LLC
    Inventors: John G. Hoey, Denise P. Dimitrov, Lisa P. Huang, Martin E. Adelson, Eli Mordechai
  • BABESIA MICROTI GENOMIC CLONES CONTAINING NOVEL ANTIGENS USEFUL IN THE DIAGNOSIS OF BABESIOSIS
    Publication number: 20130177941
    Abstract: Disclosed are the cloning and expression of novel antigens in Babesia microti. The recombinant polypeptides are highly immunogenic. The polypeptides of the present invention provide the basis of a diagnostic assay that is sensitive, rapid and accurate using patient's sera. Also disclosed is an IgG and IgM ELISA using two novel recombinant antigens in the diagnosis of Babesia infection.
    Type: Application
    Filed: December 13, 2012
    Publication date: July 11, 2013
    Applicant: Medical Diagnostic Laboratories, LLC
    Inventors: John G. Hoey, Hannah Venit, Martin E. Adelson, Eli Mordechai, Fernando Valois-Cruz
  • translocated substrate-1 (ATS-1) and sero-detection of
    Patent number: 8455211
    Abstract: Disclosed is the use of isolated Ats-1 protein in Anaplasma phagocytophilum in the ELISA detection of Anaplasma pathogen. The recombinant expression of Ats-1 and its use as a kit for ELISA are also disclosed.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: June 4, 2013
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: Denise Dimitrov, John G. Hoey
  • genomic clones containing novel antigens useful in the diagnosis of babesiosis
    Patent number: 8388981
    Abstract: Disclosed are the cloning and expression of novel antigens in Babesia microti. The recombinant polypeptides are highly immunogenic. The polypeptides of the present invention provide the basis of a diagnostic assay that is sensitive, rapid and accurate using patient's sera. Also disclosed is an IgG and IgM ELISA using two novel recombinant antigens in the diagnosis of Babesia infection.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: March 5, 2013
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: John G. Hoey, Hannah Venit, Martin E. Adelson, Eli Mordechai, Fernando Valois-Cruz
  • Protein fragments of virB10 and sero-detection of
    Patent number: 8389678
    Abstract: Disclosed are cloning and expression of a plurality of protein fragments of virB10, a Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum. Such recombinant protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as kits for ELISA is also disclosed.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: March 5, 2013
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: John G. Hoey, Denise P. Dimitrov, Lisa B. Huang, Martin E. Adelson, Eli Mordechai
  • DETECTION KIT CONTAINING A NOVEL RECOMBINANT 15-kDA POLYPEPTIDE USEFUL FOR DETECTING HUMAN INFECTION WITH BARTONELLA HENSELAE
    Publication number: 20130040323
    Abstract: Disclosed are the cloning and expression of a novel antigen of Bartonella henselae. The recombinant polypeptide is found to be highly immunogenic and is useful as a diagnostic test antigen. The polypeptide of the present invention provides the basis of a diagnostic assay that is sensitive, rapid and accurate diagnosis of infection with Bartonella henselae using patient's sera. Disclosed also are the ELISA for both IgG and IgM and allows diagnosis of early and late infection.
    Type: Application
    Filed: August 17, 2012
    Publication date: February 14, 2013
    Applicant: MEDICAL DIAGNOSTIC LABORATORIES, L.L.C.
    Inventors: John G. Hoey, Lisa P. Huang, Martin E. Adelson, Eli Mordechai
  • Type IV secretion system proteins in sero-detection of
    Patent number: 8338190
    Abstract: Disclosed are two (2) proteins in the Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum (namely, virB10 and virB11) useful in the ELISA detection of Anaplasma pathogen. The recombinant expression of virB10 and virB11 and their use as kits for ELISA are also disclosed.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: December 25, 2012
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: John G. Hoey, Denise P. Dimitrov, Lisa P. Huang, Martin E. Adelson, Eli Mordechai
  • Type IV secretion system proteins in sero-detection of
    Patent number: 8323907
    Abstract: Disclosed are two (2) proteins in the Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum (namely, virB10 and virB11) useful in the ELISA detection of Anaplasma pathogen. The recombinant expression of virB10 and virB11 and their use as kits for ELISA are also disclosed.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: December 4, 2012
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: John G. Hoey, Denise P. Dimitrov, Lisa P. Huang, Martin E. Adelson, Eli Mordechai
  • TYPE IV SECRETION SYSTEM PROTEINS IN SERO-DETECTION OF ANAPLASMA PHAGOCYTOPHILUM
    Publication number: 20120288882
    Abstract: Disclosed are two (2) proteins in the Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum (namely, virB 10 and virB 11) useful in the ELISA detection of Anaplasma pathogen. The recombinant expression of virB 10 and virB 11 and their use as kits for ELISA are also disclosed.
    Type: Application
    Filed: July 30, 2012
    Publication date: November 15, 2012
    Applicant: MEDICAL DIAGNOSTIC LABORATORIES, LLC
    Inventors: John G. Hoey, Denise P. Dimitrov, Lisa P. Huang, Martin E. Adelson, Eli Mordechai
  • Recombinant fragments and synthetic peptides of 17-kDa polypeptide useful in detecting
    Patent number: 8283439
    Abstract: The present disclosure describes recombinant and synthetic polypeptides of Bartonella henselae and related methods and kits for the detection of antibodies specific for Bartonella henselae. The 17-kDa polypeptides, methods and kits are useful in the detection of recent and/or ongoing infections with Bartonella henselae, which can be useful in the diagnosis of Cat Scratch Disease (CSD).
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: October 9, 2012
    Assignee: Medical Diagnostic Laboratories L.L.C.
    Inventors: Lisa P. Huang, John G. Hoey, Martin E. Adelson, Eli Mordechai
  • Protein fragments of virB10 and sero-detection of anaplasma phagocytophium
    Patent number: 8283130
    Abstract: Disclosed are cloning and expression of a plurality of protein fragments of virB10, a Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum. Such recombinant protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as kits for ELISA is also disclosed.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: October 9, 2012
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: John G. Hoey, Denise P. Dimitrov, Lisa P. Huang, Martin E. Adelson, Eli Mordechai
  • Recombinant 15-kDa polypeptide and use of same in detecting human infection with
    Patent number: 8268569
    Abstract: Disclosed are the cloning and expression of a novel antigen of Bartonella henselae. The recombinant polypeptide is found to be highly immunogenic and is useful as a diagnostic test antigen. The polypeptide of the present invention provides the basis of a diagnostic assay that is sensitive, rapid and accurate diagnosis of infection with Bartonella henselae using patient's sera. Disclosed also are the ELISA for both IgG and IgM and allows diagnosis of early and late infection.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: September 18, 2012
    Assignee: Medical Diagnostic Laboratories, L.L.C.
    Inventors: John G. Hoey, Lisa P. Huang, Martin E. Adelson, Eli Mordechai
  • Hemolysin and its protein fragments in sero-detection of
    Patent number: 8257938
    Abstract: Disclosed is the cloning, expression and purification of a hemolysin protein and its protein fragments in Anaplasma phagocytophilum. The recombinant hemolysin and its protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as a kit for ELISA is also disclosed.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: September 4, 2012
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: John G. Hoey, Denise P. Dimitrov, Lisa P. Huang, Martin E. Adelson, Eli Mordechai
  • Babesia microti Genomic Clones Containing Novel Antigens Useful in the Diagnosis of Babesiosis
    Publication number: 20120202227
    Abstract: Disclosed are the cloning and expression of novel antigens in Babesia microti. The recombinant polypeptides are highly immunogenic. The polypeptides of the present invention provide the basis of a diagnostic assay that is sensitive, rapid and accurate using patient's sera. Also disclosed is an IgG and IgM ELISA using two novel recombinant antigens in the diagnosis of Babesia infection.
    Type: Application
    Filed: April 5, 2012
    Publication date: August 9, 2012
    Applicant: MEDICAL DIAGNOSTIC LABORATORIES, LLC
    Inventors: John G. Hoey, Hannah Venit, Martin E. Adelson, Eli Mordechai, Fernando Valois-Cruz
  • PROTEIN FRAGMENTS OF VIRB10 AND SERO-DETECTION OF ANAPLASMA PHAGOCYTOPHILUM
    Publication number: 20120183979
    Abstract: Disclosed are cloning and expression of a plurality of protein fragments of virB10, a Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum. Such recombinant protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as kits for ELISA is also disclosed.
    Type: Application
    Filed: March 13, 2012
    Publication date: July 19, 2012
    Applicant: MEDICAL DIAGNOSTIC LABORATORIES, L.L.C.
    Inventors: John G. Hoey, Denise P. Dimitrov, Lisa P. Huang, Martin E. Adelson, Eli Mordechai