Patents by Inventor John G. Keimel

John G. Keimel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190038554
    Abstract: Aspects herein relate to systems and methods for delivery of biologic agents to the central nervous system. In various embodiments, a method of administering a therapeutic agent to the central nervous system (CNS) is included. The method can include injecting a therapeutic agent into a first cerebrospinal fluid (CSF) region of the subject. The method can further include establishing fluid communication between a fluid reservoir and a second cerebrospinal fluid (CSF) region of a subject, the fluid having a hydraulic pressure at or above an intracranial pressure. The method can further include infusing a hyperosmotic fluid systemically. Other embodiments, including kits and systems are also included herein.
    Type: Application
    Filed: February 8, 2018
    Publication date: February 7, 2019
    Inventor: John G. Keimel
  • Patent number: 10016514
    Abstract: Embodiments herein include polynucleotides, vectors and methods for the insertion and expression of transgenes. In an embodiment, a polynucleotide is included. The polynucleotide can include a JeT promoter or variant thereof, an intron sequence less than 400 bases in length, and a polynucleotide sequence encoding a polypeptide or protein operatively linked to the promoter. In an embodiment, a recombinant vector is included. The recombinant vector can include a JeT promoter or variant thereof, an intron sequence less than 400 bases in length, and a polynucleotide sequence encoding a polypeptide or protein operatively linked to the promoter. Other embodiments are also included herein.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: July 10, 2018
    Assignee: New Hope Research Foundation
    Inventors: John G. Keimel, Michael David Kaytor
  • Patent number: 9592398
    Abstract: Techniques for delivering genetic material to a target tissue site of a patient via a leadless implantable medical device that includes a pump and a stimulation energy delivery element are described. In some examples, delivery of genetic material to the target tissue site causes transgene expression of tissue at the target tissue site, which may result in generation of new cells or modified properties of existing cells of the target tissue site, facilitating more effective and efficient treatment of a disorder of the patient.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: March 14, 2017
    Assignee: Medtronic, Inc.
    Inventor: John G. Keimel
  • Publication number: 20160331846
    Abstract: Embodiments herein include polynucleotides, vectors and methods for the insertion and expression of transgenes. In an embodiment, a polynucleotide is included. The polynucleotide can include a JeT promoter or variant thereof, an intron sequence less than 400 bases in length, and a polynucleotide sequence encoding a polypeptide or protein operatively linked to the promoter. In an embodiment, a recombinant vector is included. The recombinant vector can include a JeT promoter or variant thereof, an intron sequence less than 400 bases in length, and a polynucleotide sequence encoding a polypeptide or protein operatively linked to the promoter. Other embodiments are also included herein.
    Type: Application
    Filed: May 3, 2016
    Publication date: November 17, 2016
    Inventors: John G. Keimel, Michael David Kaytor
  • Patent number: 9314511
    Abstract: The present invention is directed to systems and methods for delivering therapy for a cardiac disorder, wherein the system comprises a source for supplying a protein formulation containing a protein that is otherwise deficient in cardiac cells in a patient with a cardiac disorder, and a catheter having a proximal end and a distal end for delivering the protein formulation to the pericardial sac region of a human heart.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: April 19, 2016
    Assignee: Medtronic, Inc.
    Inventor: John G. Keimel
  • Publication number: 20150375006
    Abstract: A method for delivering optical stimulation comprises transfecting a target tissue with a light-sensitive channel protein sensitive to light in a wavelength range, delivering light in the wavelength range to the target tissue via an optical stimulation device, substantially simultaneously with delivering light to the target tissue, sensing bioelectric signals, determining a patient therapeutic state based on the bioelectric signals, and adjusting the delivery of the light to the target tissue based on the sensed patient therapeutic state.
    Type: Application
    Filed: June 5, 2015
    Publication date: December 31, 2015
    Inventors: Timothy J. Denison, Kunal Paralikar, Gordon Orvis Munns, Wesley A. Santa, Peng Cong, Christian S. Nielsen, John D. Norton, John G. Keimel
  • Publication number: 20140012230
    Abstract: The present invention is directed to systems and methods for delivering therapy for a cardiac disorder, wherein the system comprises a source for supplying a protein formulation containing a protein that is otherwise deficient in cardiac cells in a patient with a cardiac disorder, and a catheter having a proximal end and a distal end for delivering the protein formulation to the pericardial sac region of a human heart.
    Type: Application
    Filed: July 12, 2013
    Publication date: January 9, 2014
    Applicant: MEDTRONIC, INC.
    Inventor: John G. Keimel
  • Patent number: 8500720
    Abstract: The present invention is directed to systems and methods for delivering therapy for a cardiac disorder, wherein the system comprises a source for supplying a protein formulation containing a protein that is otherwise deficient in cardiac cells in a patient with a cardiac disorder, and a catheter having a proximal end and a distal end for delivering the protein formulation to the pericardial sac region of a human heart.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: August 6, 2013
    Assignee: Medtronic, Inc
    Inventor: John G. Keimel
  • Patent number: 8419710
    Abstract: Methods for delivering first and second fluid compositions to a target location of a subject include delivering the first composition from reservoir of an implantable infusion pump and delivering the second composition through a catheter access port of the implantable infusion device. The access port and reservoir are fluidly coupled to a catheter having a delivery region implanted in the target region. The methods more fully realize the therapeutic potential of infusion devices having both an access port and a reservoir. Strategic use of different agents that compliment the function of each other delivered via either the access port or the reservoir can result in enhanced therapeutic potential.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: April 16, 2013
    Assignee: Medtronic, Inc.
    Inventors: John G. Keimel, William F. Kaemmerer
  • Publication number: 20120290025
    Abstract: Techniques for delivering genetic material to a target tissue site of a patient via a leadless implantable medical device that includes a pump and a stimulation energy delivery element are described. In some examples, delivery of genetic material to the target tissue site causes transgene expression of tissue at the target tissue site, which may result in generation of new cells or modified properties of existing cells of the target tissue site, facilitating more effective and efficient treatment of a disorder of the patient.
    Type: Application
    Filed: May 12, 2011
    Publication date: November 15, 2012
    Applicant: Medtronic, Inc.
    Inventor: John G. Keimel
  • Patent number: 8135470
    Abstract: Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patient's amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patient's energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patient's stimulation therapy parameters.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: March 13, 2012
    Assignee: Medtronic, Inc.
    Inventors: John G. Keimel, Warren L. Starkebaum, Gary L. Lubben
  • Publication number: 20110213328
    Abstract: The present invention is directed to methods and systems for the treatment of inborn genetic errors or other defects that cause deficiencies of active enzymes or proteins within the cells of the central nervous system. Such methods and systems generally comprise an implantable catheter system designed for the chronic delivery of specially formulated proteins to intrathecal, intracerebroventricular, and/or intraparenchymal regions of the central nervous system. The invention has application in the neuropathic aspects of the broad category of lysosomal storage diseases. These genetic based diseases are the result of insufficient enzyme activity to catabolize specific substances, which thereby accumulate in the cellular lysosomes.
    Type: Application
    Filed: May 10, 2011
    Publication date: September 1, 2011
    Applicant: MEDTRONIC, INC.
    Inventors: John G. Keimel, William F. Kaemmerer
  • Publication number: 20110125078
    Abstract: A method for delivering optical stimulation comprises transfecting a target tissue with a light-sensitive channel protein sensitive to light in a wavelength range, delivering light in the wavelength range to the target tissue via an optical stimulation device, substantially simultaneously with delivering light to the target tissue, sensing bioelectric signals, determining a patient therapeutic state based on the bioelectric signals, and adjusting the delivery of the light to the target tissue based on the sensed patient therapeutic state.
    Type: Application
    Filed: November 22, 2010
    Publication date: May 26, 2011
    Applicant: Medtronic, Inc.
    Inventors: Timothy J. Denison, Kunal Paralikar, Gordon O. Munns, Wesley A. Santa, Peng Cong, Christian S. Nielsen, John D. Norton, John G. Keimel
  • Publication number: 20090240194
    Abstract: Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patient's amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patient's energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patient's stimulation therapy parameters.
    Type: Application
    Filed: June 2, 2009
    Publication date: September 24, 2009
    Applicant: Medtronic, Inc.
    Inventors: John G. Keimel, Warren L. Starkebaum, Gary L. Lubben
  • Patent number: 7558629
    Abstract: Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patient's amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patient's energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patient's stimulation therapy parameters.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: July 7, 2009
    Assignee: Medtronic, Inc.
    Inventors: John G. Keimel, Warren L. Starkebaum, Gary L. Lubben
  • Publication number: 20080140048
    Abstract: Methods for delivering first and second fluid compositions to a target location of a subject include delivering the first composition from reservoir of an implantable infusion pump and delivering the second composition through a catheter access port of the implantable infusion device. The access port and reservoir are fluidly coupled to a catheter having a delivery region implanted in the target region. The methods more fully realize the therapeutic potential of infusion devices having both an access port and a reservoir. Strategic use of different agents that compliment the function of each other delivered via either the access port or the reservoir can result in enhanced therapeutic potential.
    Type: Application
    Filed: December 6, 2007
    Publication date: June 12, 2008
    Applicant: MEDTRONIC, INC.
    Inventors: John G. Keimel, William F. Kaemmerer
  • Publication number: 20080140056
    Abstract: A method for delivering a large molecule to the brain includes administering the large molecule via an intermittent bolus regimen intrathecally to a subject at a level of C3 or above. A method for delivering a large molecule to the brain includes rostrally advancing a catheter in the intrathecal space of a subject until a delivery region of the catheter is located at a level of C3 or above and delivering the large molecule via the delivery region. Employing aspects of such methods, a method for altering eating behavior is described.
    Type: Application
    Filed: December 6, 2007
    Publication date: June 12, 2008
    Applicant: MEDTRONIC, INC.
    Inventors: John G. Keimel, William F. Kaemmerer
  • Publication number: 20080140008
    Abstract: An intrathecal catheter for delivering fluid to, or withdrawing fluid from, the cerebrospinal fluid compartment of a patient, includes a proximal end and a distal portion. The distal portion has an outer diameter of about 1 mm or less, a bending stiffness of about 0.002 pounds per square inch or less, and a distal end. A delivery region is located between the proximal end and the distal end, and a lumen extends from the proximal end to the delivery region. The catheter may further include a coiled structure region to prevent dislodgement of the catheter from a tissue in which the coiled structure is implanted, for example the cisterna magna. The catheter may also include tines to anchor portions of the catheter, for example to a portion of the spinal canal.
    Type: Application
    Filed: December 6, 2007
    Publication date: June 12, 2008
    Applicant: MEDTRONIC, INC.
    Inventors: John G. Keimel, William F. Kaemmerer, Mary M. Morris
  • Patent number: 6666821
    Abstract: An improved implantable sensor system is disclosed that includes an array of sensors. Each of the sensors is associated with a protective member that prevents the sensor from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor to begin sensing signals within a living body. In one embodiment, the protective member is formed of a conductive material that can oxidize, is biocompatible, bio-absorbable, and that may be dissolved in solution such as blood upon application of an electric potential. In another embodiment, the protective member is formed of a dissolvable member that dissolves within the body over a predetermined time period.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: December 23, 2003
    Assignee: Medtronic, Inc.
    Inventor: John G. Keimel
  • Patent number: 6650942
    Abstract: An implantable medical device having a dual cell power source powering a high-power output circuit and a low-power control circuit. The power source includes a first, high-rate cell and a second, lower-rate cell having a rate capability less than a rate capability of the first, high-rate cell. The first and second cells are electrically connected to the output circuit and control circuit by circuitry. In one embodiment, the circuitry connects the first and second cells in parallel to the output circuit and the control circuit, and includes a switching circuit for selectively uncoupling the first, high-rate cell from the control circuit during a transient high power pulse. In another embodiment, the first and second cells are formed within a single case and are connected in parallel to the output circuit and the control circuit.
    Type: Grant
    Filed: May 30, 2001
    Date of Patent: November 18, 2003
    Assignee: Medtronic, Inc.
    Inventors: William G. Howard, John G. Keimel, Craig L. Schmidt