Patents by Inventor John G. MONROE

John G. MONROE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions targeting viral and cellular ITAM motifs, and use of same in identifying compounds with therapeutic activity
    Patent number: 8859503
    Abstract: This invention provides methods of treating, reducing the incidence of, and inhibiting metastasis formation of carcinomas, sarcomas, Epstein-Barr virus-induced malignancies, B cell proliferative disorders, and mast cell activation disorders, comprising administering to a subject a compound that inhibits an interaction of a first protein and an immunoreceptor tyrosine-based activation motif (ITAM) of a second protein, and screening methods for identifying ITAM-inhibitory compounds and peptides. This invention also provides peptides that inhibit signaling by ITAMs.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: October 14, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: John G Monroe, Elad Katz, Ramachandran Murali
  • METHODS AND COMPOSITIONS TARGETING VIRAL AND CELLULAR ITAM MOTIFS, AND USE OF SAME IN IDENTIFYING COMPOUNDS WITH THERAPEUTIC ACTIVITY
    Publication number: 20090258032
    Abstract: This invention provides methods of treating, reducing the incidence of, and inhibiting metastasis formation of carcinomas, sarcomas, Epstein-Barr virus-induced malignancies, B cell proliferative disorders, and mast cell activation disorders, comprising administering to a subject a compound that inhibits an interaction of a first protein and an immunoreceptor tyrosine-based activation motif (ITAM) of a second protein, and screening methods for identifying ITAM-inhibitory compounds and peptides. This invention also provides peptides that inhibit signaling by ITAMs.
    Type: Application
    Filed: December 10, 2008
    Publication date: October 15, 2009
    Inventors: John G. MONROE, Elad KATZ, Ramachandran MURALI
  • METHOD OF INDUCING APOPTOSIS IN B-LYMPHOCYTES
    Publication number: 20020019332
    Abstract: A method for inducing apoptosis in B-lymphocytes is provided that involves contacting B lymphocytes with an inhibitor of protein kinase C.
    Type: Application
    Filed: July 2, 1999
    Publication date: February 14, 2002
    Inventors: JOHN G. MONROE, LESLIE B. KING