Patents by Inventor John G. Ondeyka

John G. Ondeyka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the prevention and/or treatment of atherosclerosis
    Publication number: 20030086923
    Abstract: The instant invention provides a method for raising serum HDL cholesterol levels comprising administering a therapeutically effective amount of an LXR ligand to a patient in need of such treatment. It further provides a method for using an LXR ligand to stimulate expression of the ABC1 gene. LXR ligands can be used for preventing and treating atherosclerosis and related conditions.
    Type: Application
    Filed: October 1, 2002
    Publication date: May 8, 2003
    Inventors: Carl P. Sparrow, John G. Ondeyka, Bruno Tse, Sheo Bux Singh
  • Antiparasitic agents
    Patent number: 5945317
    Abstract: Novel compounds isolated from the fermentation of producing cultures of Nodulisporium sp. are antiparasitic and insecticidal agents.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: August 31, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Kevin M. Byrne, Arlene M. Dahl, Anne Dombrowski, Joyce A. Greene, John G. Ondeyka, Dan A. Ostlind, Sheo Bux Singh, Diane M. Vesey
  • Antiparasitic agents
    Patent number: 5834260
    Abstract: Novel compounds isolated from the fermentation of producing cultures of Nodulisporium sp. are antiparasitic and insecticidal agents.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: November 10, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Kevin M. Byrne, Arlene M. Dahl, Anne Dombrowski, Joyce A. Greene, John G. Ondeyka, Dan A. Ostlind, Sheo Bux Singh, Diane M. Vesey
  • Antiparasitic agents
    Patent number: 5614546
    Abstract: There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: March 25, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Richard G. Endris, Gregory L. Helms, Otto D. Hensens, John G. Ondeyka, Dan A. Ostlind, Jon D. Polishook, Deborah L. Zink
  • Antiparasitic agents
    Patent number: 5399582
    Abstract: There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: March 21, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Richard G. Endris, Gregory L. Helms, Otto D. Hensens, John G. Ondeyka, Dan A. Ostlind, Jon D. Polishook, Deborah L. Zink
  • Antiviral agent
    Patent number: 5183826
    Abstract: An antiviral agent produced by Hypoxylon fragiforme and having the structure: ##STR1## is described. The product has high activity as an HIV protease enzyme inhibitor and is useful in the treatment of diseases in which control of HIV protease activity is desirable.
    Type: Grant
    Filed: September 25, 1990
    Date of Patent: February 2, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, Otto D. Hensens, Lawrence Koupal, Russell B. Lingham, John G. Ondeyka, Deborah L. Zink
  • Derivatives of paraherquamide isolated from a fermentation broth active as antiparasitic agents
    Patent number: 4873247
    Abstract: Paraherquamide is a fungal metabolite isolated from the known fungus Penicillium paraherquei, and from a newly isolated strain of the fungus Penicillium charlesii. Additional compounds are disclosed which are related to paraherquamide and have been isolated from Penicillium charlesii. The compounds are potent antiparasitic agents. Compositions including such compounds as the active ingredient thereof for antiparasitic uses against endo and ecto parasites are also disclosed, as well as process for the preparation of such compounds from the newly isolated fungus.
    Type: Grant
    Filed: November 27, 1987
    Date of Patent: October 10, 1989
    Inventors: Robert T. Goegelman, John G. Ondeyka
  • Anti-inflammatory and antidegenerative compounds isolated from L-681,512
    Patent number: 4871727
    Abstract: There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of sail microorganism L-681,512 under controlled fermentation conditions.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: October 3, 1989
    Assignee: Merck & Co, Inc.
    Inventors: Richard W. Burg, Eugene L. Dulaney, Otto D. Hensens, Jerrold M. Liesch, John G. Ondeyka, Carol F. Wichmann