Abstract: Described herein are methods and computer systems for classification of CD8 T-cell topology using a patient response-based linear cutoff model. A plurality of histology images of tissue samples in a plurality of patients are received by a computer system. An image analysis of the plurality of histology images is performed to obtain a CD8+ T-cell abundance in the tumor parenchyma and stroma in each of the plurality of histology images. Real inflammation scores and tumor infiltration scores are determined based on a polar coordinate transformation of the CD8+ T-cell abundance in the tumor parenchyma and stroma. Based on the real inflammation scores and tumor infiltration scores, a feature space is generated, and linear boundaries or linear cutoffs between a plurality of classifications in the feature space are identified based on the real inflammation scores, the tumor infiltration scores, and patient response data.

Abstract: In a general aspect, a construction tool can include a template portion arranged in a first plane. The template portion can include a rectangular plate having a slot defined, the slot being angled with respect to an edge of the plate and configured to facilitate marking a cut line on a construction material. The construction tool can also include a base portion arranged in a second plane, the second plane being orthogonal to the first plane. The base portion can include a first portion disposed on a first side of the plate, and a second portion disposed on a second side of the plate of the template portion that is opposite the first side of the plate. The first portion of the base portion can have a first thickness, and the second portion of the base portion having a second thickness that is different than the first thickness.

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

Abstract: Devices, systems, and methods for coupling tubing to a fluid reservoir to provide liquid to an endoscope system. A manifold for coupling to a fluid reservoir and a tubing assembly may include first portion interfacing with an interior of the fluid reservoir and a second portion configured to interface with tubing to be fluidly coupled to the interior of the reservoir. The first portion may include one or more openings to allow gas to pass into the fluid reservoir and liquid to pass out of the fluid reservoir. The second portion may include one or more ports for connecting to tubing that brings gas to the fluid reservoir and receives liquid from the fluid reservoir. The manifold may include a valve that selectively allows gas to pass into the fluid reservoir.

Abstract: A compact hydraulic particle separator apparatus is disclosed. The disclosed apparatus comprises an upper chamber and a lower chamber separated by a partition. A liquid fluid flow upwelling through the partition from the lower chamber is caused to mix with tangential jet of fluid flowing introduced above the partition in the upper chamber produces an upwardly-flowing cyclonic flow within the upper chamber. Particle mixtures containing low- and high-density particles and other solids are introduced into the upper chamber through a feed tube having a mouth that is offset from the center of the upper chamber. Low-density particles are immediately entrained in the cyclonic flow and swept upward and exit the apparatus.

Abstract: Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may implement a wakeword detection component to detect when captured speech includes a wakeword. A companion application installed on the device may implement a wakeword detection component trained using speech of a user of the device. If the DSP’s wakeword detection component detects a wakeword in speech, the companion application’s wakeword detection component may be used to determine whether the wakeword was spoken by the user of the device. If the companion application’s wakeword detection component determines the user spoke the wakeword, audio data representing the speech may be sent to at least one server(s) for processing.

Abstract: Techniques for processing incoming audio using multiple wakeword detectors are described. Audio data representing an utterance may be processed by different wakeword detectors that can detect different wakewords and are associated with different speech processing components. When a wakeword is detected by one of the wakeword detectors, it may be processed by the corresponding speech processing component.

Abstract: In a general aspect, a construction tool can include a template portion arranged in a first plane. The template portion can include a rectangular plate having a slot defined, the slot being angled with respect to an edge of the plate and configured to facilitate marking a cut line on a construction material. The construction tool can also include a base portion arranged in a second plane, the second plane being orthogonal to the first plane. The base portion can include a first portion disposed on a first side of the plate, and a second portion disposed on a second side of the plate of the template portion that is opposite the first side of the plate. The first portion of the base portion can have a first thickness, and the second portion of the base portion having a second thickness that is different than the first thickness.

Abstract: A filter covering for a sterile container lid, for completely covering at least one gas exchange portion, which is provided on a lid component of the sterile container lid, on an outside of the sterile container lid, the filter covering having at least two clip portions arranged opposite to each other on the filter covering, which are adapted to engage in a form-fitting manner in at least two clip receiving portions provided on the lid component, and by which the filter covering is mountable to and dismountable from the lid component without tools.

Abstract: Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may initially include an untrained wakeword detection component. The wakeword detection component of the DSP may be trained by engaging a user to speak particular utterances. Once a companion application is configured to implement a wakeword detection component, the companion application's wakeword detection component may be trained specific to the user of the device. Once the companion application's wakeword detection component is trained, the DSP wakeword detection component may be deactivated or its accuracy adjusted.

Abstract: One or more systems and methods are presented for secure data communications utilizing blockchains. One or more systems and methods may utilize multiple blockchains to provide an immutable cryptographically linked set of blocks. Each of these blocks may contain one or more actions associated with a computer network. In one embodiment, a trusted third party may be utilized to authenticate and/or verify data prior to inputting data into one or more blockchains.

Abstract: A modularly structured lid for a sterile container includes a lid component, which has at least one gas exchange portion, on which, on the inner side of a lid, at least one filter device can be arranged, and at least one filter covering by which the at least one gas exchange portion can be completely covered on an outside of the lid. The lid component has at least one standardized clip receiving portion and the filter covering has at least one standardized clip portion, by which the filter covering and the lid component can be interlockingly fixed to each other, and can be mounted and removed without tools. A sterile container can include such a lid and a filter covering for such a lid.

Abstract: A respiratory humidification system humidifies a flow of respiratory gases supplied to a user. The system can include a main housing that receives a humidification chamber, a heating plate included in the main housing and positioned to contact the humidified chamber and transfer heat to the humidifier chamber, and a heating element that provides heat to the heating plate. The heating element can include a temperature sensor disposed in a central region of the heating element. Disposing the temperature sensor in the central region can reduce a likelihood that conductors of the heating element will cause an incorrect temperature measurement by the temperature sensor.

Abstract: A drain valve for a sterile container includes: a valve housing; a bypass that connects a container gas volume with an external gas volume; a valve body that blocks the bypass; and an actuator that displaces the valve body between a passage position and a blocking position. The valve body is displaceable according to a temperature and/or a pressure of the bypass gas volume. The valve housing has: at least one holding web, at least part of which can be located in a holding bracket of the valve receptacle; and a closure. The valve housing is pivotable from an open position into an installation position in which the closure can be fixed to a closure receptacle. When the valve housing is transferred into the installation position, the valve body is transferred into the blocking position and subjected to a closure force.