Patents by Inventor John G. Winchester

John G. Winchester has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • P-anisoyl streptokinase/plasminogen complex
    Patent number: 4808405
    Abstract: A binary complex between streptokinase and plasminogen is prepared in which the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis such that the pseudo-first order rate constant for hydrolysis of the complex is in the range 10.sup.-6 sec.sup.-1 to 10.sup.-3 sec.sup.-1 in isotonic aqueous media at pH 7.4 at 37.degree. C. The complex is preferably a p-anisoyl streptokinase/plasminogen complex without internal peptide bond cleavage. The complex is useful in the treatment of venous thrombosis.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: February 28, 1989
    Assignee: Beecham Group p.l.c.
    Inventors: Richard A. G. Smith, John G. Winchester