Patents by Inventor John G. Wise
John G. Wise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220175777Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: January 26, 2022Publication date: June 9, 2022Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Patent number: 11234978Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: September 26, 2019Date of Patent: February 1, 2022Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Patent number: 11013739Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: November 6, 2019Date of Patent: May 25, 2021Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit, Amila K. Nanyakkara, Alexander R. Lippert, Maha Ali Aljowni
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Publication number: 20210134398Abstract: A method for identifying a potentially useful molecular combination includes applying a selection procedure to a compound to identify a first set of candidate molecules, the procedure including providing a chemical synthesis scheme, a virtual scaffold molecule of the compound, and a virtual reactant fragment to react with the scaffold molecule according to the scheme; preparing the reactant fragment and the scaffold molecule for analyzing combinations of them; designating a remaining scaffold subset and a remaining fragment subset if a product molecule can be formed from them; rotating the fragment subset about an axis connecting the scaffold subset and the fragment subset incrementally through 360 degrees; and identifying potentially useful combinations of the reactant fragment and the scaffold molecule; identifying a set of combinatorial fragments from the first set of candidates; and applying the selection procedure to the set of combinatorial fragments to identify a second set of candidate molecules.Type: ApplicationFiled: November 6, 2020Publication date: May 6, 2021Inventors: John G. Wise, Pia D. Vogel
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Patent number: 10898485Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: December 16, 2019Date of Patent: January 26, 2021Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Publication number: 20200138816Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: December 16, 2019Publication date: May 7, 2020Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Publication number: 20200069687Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: November 6, 2019Publication date: March 5, 2020Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit, Amila K. Nanyakkara, Alexander R. Lippert, Maha Ali Aljowni
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Patent number: 10548893Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: November 29, 2018Date of Patent: February 4, 2020Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Patent number: 10543210Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: March 27, 2019Date of Patent: January 28, 2020Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Alexander R. Lippert, Amila K. Nanyakkara, Maha A. Aljowni
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Publication number: 20200016157Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: September 26, 2019Publication date: January 16, 2020Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Publication number: 20190216811Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: March 27, 2019Publication date: July 18, 2019Inventors: John G. Wise, Pia D. Vogel, Alexander R. Lippert, Amila K. Nanyakkara, Maha A. Aljowni
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Patent number: 10292982Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: March 5, 2018Date of Patent: May 21, 2019Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Alexander R. Lippert, Amila K. Nanyakkara, Maha A. Aljowni
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Publication number: 20190091223Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: November 29, 2018Publication date: March 28, 2019Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Patent number: 10172855Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: January 13, 2017Date of Patent: January 8, 2019Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Publication number: 20180185366Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: March 5, 2018Publication date: July 5, 2018Inventors: John G. Wise, Pia D. Vogel, Alexander R. Lippert, Amila K. Nanyakkara, Maha A. Aljowni
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Publication number: 20170128447Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: January 13, 2017Publication date: May 11, 2017Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Patent number: 9561227Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: January 15, 2015Date of Patent: February 7, 2017Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Publication number: 20150196560Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: January 15, 2015Publication date: July 16, 2015Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Publication number: 20080153026Abstract: A carrier containing a core, a polymer coating, mixtures of polymers, or a plurality of polymers thereover, and wherein at least one of, and more specifically, one of the coating polymers, includes graphite.Type: ApplicationFiled: December 21, 2006Publication date: June 26, 2008Inventors: Brian S. Giannetto, Samir Kumar, Thomas J. Budny, Brian E. Moore, John G. Wise, D. Paul Casalmir
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Publication number: 20040161753Abstract: Methods are provided for identification and production of new DNA binding proteins that up or down regulate the expression of pre-determined target genes. Such genes include DNA sequences that encode proteins that regulate such target genes as well as gene constructs and biological materials that contain such DNA binding proteins and/or their DNA sequences. Discovery methods also are provided for transcriptional promoters that allow identification of the desired target gene specific DNA binding proteins, methods for targeting DNA binding protein variants to the desired DNA binding sequence, the methods for removing undesired DNA binding protein variants from the total pool of all variants, as well as the media used for assaying in vivo DNA binding. The invention further encompasses kits for the identification and production of DNA binding protein variants and/or their DNA sequences.Type: ApplicationFiled: October 31, 2003Publication date: August 19, 2004Inventors: John G. Wise, Katja Fromknecht