Abstract: Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y=C, or substituted diene fused to Y when Y=C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.

Abstract: Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y=C, or substituted diene fused to Y when Y=C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.

Abstract: Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substituted alkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substituted phenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y?C, or substituted diene fused to Y when Y?C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.

Abstract: Compounds of Formula (I), are provided where T is CHO, CON, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y?C, or substituted diene fused to Y when Y?C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.

Abstract: A preknotted adjustable necktie is provided containing no rigid materials comprising a first outer tie portion having a front wide flap segment integral with a knot segment with an opening therethrough; and a second inner tie portion having an adjustable neck embracing loop extending through the opening in said knot segment.

Abstract: Compounds of Formula (I), 1

Abstract: A preknotted adjustable necktie is provided containing no rigid materials comprising a first outer tie portion having a front wide flap segment integral with a knot segment with an opening therethrough; and a second inner tie portion having an adjustable neck embracing loop extending through the opening in said knot segment.

Abstract: The present invention provides a preknotted adjustable necktie comprising a front outer tie portion, a knot portion with an opening therethrough, and an adjustable neck embracing loop extending through the opening in said knot portion. The knot portion is formed of fabric material and contains no rigid materials, the knot portion having an outer knot segment attached on its vertically extending side edges to an inner knot segment, with one end of the neck embracing loop attached to a first side of the inner knot segment and the other end of the neck embracing loop extending through a guide loop attached to the first side of the inner knot segment, with the front outer tie portion attached to the other side of the inner knot segment, and with the outer knot segment being attached at its opposing side edges forming the opening through the knot portion.

Abstract: The present invention provides a preknotted adjustable necktie comprising a front outer tie portion, a knot portion with an opening therethrough, and an adjustable neck embracing loop extending through the opening in said knot portion. The knot portion is formed of fabric material and contains no rigid materials, the knot portion having an outer knot segment attached on its vertically extending side edges to an inner knot segment, with one end of the neck embracing loop attached to a first side of the inner knot segment and the other end of the neck embracing loop extending through a guide loop attached to the first side of the inner knot segment, with the front outer tie portion attached to the other side of the inner knot segment, and with the outer knot segment being attached at its opposing side edges forming the opening through the knot portion.

Abstract: A preknotted adjustable necktie is provided containing no rigid materials comprising a first outer tie portion having a front wide flap segment integral with a knot segment with an opening therethrough; and a second inner tie portion having an adjustable neck embracing loop extending through the opening in said knot segment.

Abstract: A jacket is provided made with a conventional continuous folded collar and lapel and having a zipper for attaching an interchangeable collar and lapel member with the conventional collar and lapel providing support. and shape for the interchangeable member and at least a portion of the conventional collar and lapel is outwardly visible when the interchangeable member is attached.