Patents by Inventor John Gary Montana

John Gary Montana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxamic and carboxylic acid derivatives
    Patent number: 6506764
    Abstract: Compounds of the formula B—X—(CH2)m—CR1R2—(CH2)n—CO—Y  (I) have therapeutic utility as inhibitors of metalloproteinases etc.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: January 14, 2003
    Assignee: Darwin Discovery, Ltd.
    Inventors: Andrew Douglas Baxter, David Alan Owen, Duncan Hannah, John Gary Montana
  • Hydroxamic and carboxylic acid derivatives
    Patent number: 6503910
    Abstract: Compounds of the formula (B)2N—X—(CH2)n—CR1R2—CO—Y  (I) have therapeutic utility as inhibitors of metalloproteinases etc.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: January 7, 2003
    Assignee: Darwin Discovery Ltd.
    Inventors: Andrew Douglas Baxter, David Alan Owen, Robert John Watson, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Publication number: 20020183358
    Abstract: N-oxides of formula (i) 1
    Type: Application
    Filed: May 16, 2002
    Publication date: December 5, 2002
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Hydroxamic acid derivatives as matrix metalloproteinase (mmp) inhibitors
    Patent number: 6462042
    Abstract: Compounds having therapeutic utility are of formula (I) wherein B1, B2, R1 and R2 are each various sub-stituents, or R1 and R2 together form a ring.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: October 8, 2002
    Assignee: Darwin Discovery Limited
    Inventors: David Alan Owen, Andrew Douglas Baxter, Robert John Watson, John Gary Montana
  • Hydroxamic acid derivatives
    Patent number: 6455531
    Abstract: Compounds having therapeutic utility are of the formula wherein NB2 is heterocycloalkyl and R1 and R2 are each various substituents or a cyclic group.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: September 24, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: David Alan Owen, Andrew Douglas Baxter, Robert John Watson, Duncan Robert Hannah, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6455561
    Abstract: The present invention pertains to compositions and methods for treating disease states which are capable of being modulated by inhibition of phosphodiesterase IV or Tumour Necrosis Factor, or that is a pathological condition associated with a function of phosphodiesterase IV, eosinophil accumulation or a function of the eosinophil, said method comprising administering to a person or animal in need of such treatment an effective amount of the compound of a formula wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is CH2OCH3 or 2 or 3-tetrahydrofuranyl; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C) R4 is C 1-3 alkyl; and R5 and R6, which may be the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: September 24, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, Christopher Lowe, John Gary Montana
  • Bicyclic aryl carboxamides and their therapeutic use
    Publication number: 20020094987
    Abstract: Compounds of the formula (i) 1
    Type: Application
    Filed: January 14, 2002
    Publication date: July 18, 2002
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6410559
    Abstract: N-oxides of formula (i) wherein R1 is CH3, CH2F, CHF2 or CF3; R2 is CH3 or CF3; R3 is F, Cl, Br, CN or CH3; and R4 is H, F, Cl, Br, CN or CH3; and pharmaceutically-acceptable salts thereof, are useful as therapeutic agents, e.g., for the treatment of inflammatory diseases.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: June 25, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6403791
    Abstract: A compound of the formula wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is C1-6 alkyl, cycloalkyl or NR4R5; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C) NR4R5 is a nitrogen-containing heterocyclic ring; R6 is C1-3 alkyl; and R7 and R8, which are the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: June 11, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, Alan Findlay Haughan, Christopher Lowe, George Martin Buckley, Richard John Davenport, Andrew Sharpe, Hannah Jayne Kendall, Verity Margaret Sabin, John Gary Montana, Catherine Louise Picken
  • Selective MMP inhibitors having reduced side-effects
    Publication number: 20020035065
    Abstract: The subject invention pertains to matrix metalloproteinase (MMP) inhibitors that exhibit an IC50 of below 10−4M against MMP and have substantially no activity against non-MMP metalloproteinase-related events. The MMP inhibitors of the invention have reduced side-effects, especially with respect to joint pain.
    Type: Application
    Filed: May 21, 2001
    Publication date: March 21, 2002
    Inventors: John Bird, John Gary Montana, Ruth Elizabeth Wills, Andrew Douglas Baxter, David Alan Owen
  • Bicyclic aryl carboxamides and their therapeutic use
    Patent number: 6353010
    Abstract: Compounds of the formula (i) have therapeutic utility via inhibition of TNF or phosphodiesterase.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: March 5, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Publication number: 20020022645
    Abstract: The present invention pertains to compositions and methods for treating disease states which are capable of being modulated by inhibition of phosphodiesterase IV or Tumour Necrosis Factor, or that is a pathological condition associated with a function of phosphodiesterase IV, eosinophil accumulation or a function of the eosinophil, said method comprising administering to a person or animal in need of such treatment an effective amount of the compound of a formula 1
    Type: Application
    Filed: October 12, 2001
    Publication date: February 21, 2002
    Inventors: Hazel Joan Dyke, Christopher Lowe, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6331556
    Abstract: A compound of the formula wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is CH2OCH3 or 2 or 3-tetrahydrofuranyl; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C)  R4 is C1-3 alkyl; and R5 and R6, which may be the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: December 18, 2001
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, Christopher Lowe, John Gary Montana
  • Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
    Patent number: 6310088
    Abstract: Compounds of formula (I) are useful therapeutic agents, by virtue of having MMP and TNF inhibitory activity.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: October 30, 2001
    Assignee: Darwin Discovery, Ltd.
    Inventors: Andrew Douglas Baxter, David Alan Owen, John Gary Montana, Elizabeth Jane Reed Nicholson
  • Heterocyclic compounds and their therapeutic use
    Publication number: 20010031777
    Abstract: A compound of the formula 1
    Type: Application
    Filed: February 9, 2001
    Publication date: October 18, 2001
    Inventors: Hazel Joan Dyke, Christopher Lowe, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Publication number: 20010025049
    Abstract: N-oxides of formula (i) 1
    Type: Application
    Filed: March 30, 2001
    Publication date: September 27, 2001
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6262070
    Abstract: N-oxides of formula (i) wherein R1 is CH3, CH2F, CHF2 or CF3; R2 is CH3 or CF3; R3 is F, Cl, Br, CN or CH3; and R4 is H, F, Cl, Br, CN or CH3; and pharmaceutically-acceptable salts thereof, are useful as therapeutic agents, e.g. for the treatment of inflammatory diseases.
    Type: Grant
    Filed: November 3, 1999
    Date of Patent: July 17, 2001
    Assignee: Darwin Discovery Ltd.
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
    Patent number: 6187924
    Abstract: Compounds of formula (I) are useful as therapeutic agents, by virtue of having MMP and TNF inhibitory activity.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: February 13, 2001
    Assignee: Darwin Discovery, Ltd.
    Inventors: Andrew Douglas Baxter, David Alan Owen, John Gary Montana, Robert John Watson
  • Tetrahydronapthalene derivatives and their therapeutic use
    Patent number: 6133240
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is a fucose or mannose residue, have therapeutic utility via inhibition of selectins, and thus of cell adhesion.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 17, 2000
    Assignee: Darwin Discovery, Ltd.
    Inventors: Richard John Kenneth Taylor, Paul Vincent Murphy, John Gary Montana, David Thomas Manallack
  • Xanthines and their therapeutic use
    Patent number: 6124288
    Abstract: The subject invention concerns a compound of the formula (i): ##STR1## in which Q represents heteroaryl or heterocyclo optionally substituted with one or more substituents selected from the group consisting of C.sub.1-6 alkyl (optionally substituted with one or more halogens), C.sub.1-6 alkyl--S(O)n-- (where n is 0, 1 or 2), --CO.sub.2 H (or C.sub.1-6 alkyl esters thereof or C.sub.1-6 alkyl amides thereof), halogen, C.sub.1-6 alkoxy, CN, NO.sub.2 and NR.sub.7 R.sub.8;R.sub.1 -R.sub.5, which may be the same or different, each represent C.sub.1-6 alkyl (optionally substituted with one or more halogens), C.sub.1-6 alkyl--S(O)n-- (where n is 0, 1 or 2), --CO.sub.2 H (or C.sub.1-16 alkyl esters thereof or C.sub.1-6 alkyl amides thereof), halogen, C.sub.1-6 alkoxy, CN, NO.sub.2, NR.sub.7 R.sub.8 or H (provided R.sub.1 -R.sub.6 are not all H simultaneously);R.sub.6 represents H, C.sub.1-6 alkyl, --CO.sub.2 H (or C.sub.1-6 alkyl esters thereof or C.sub.1-6 alkyl amides thereof), --CN, C.sub.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: September 26, 2000
    Assignee: Darwin Discovery, Ltd.
    Inventor: John Gary Montana