Patents by Inventor John Gebe

John Gebe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF MHC CLASS II EPITOPE MAPPING, DETECTION OF AUTOIMMUNE T CELLS AND ANTIGENS, AND AUTOIMMUNE TREATMENT
    Publication number: 20090226471
    Abstract: The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
    Type: Application
    Filed: February 20, 2009
    Publication date: September 10, 2009
    Applicant: BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
    Inventors: WILLIAM W. KWOK, GERALD NEPOM, JOHN GEBE, HELENA REIJONEN, ANDREW LIU
  • Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment
    Publication number: 20060240482
    Abstract: The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
    Type: Application
    Filed: June 22, 2006
    Publication date: October 26, 2006
    Applicant: Benaroya Research Institute at Virginia Mason
    Inventors: William Kwok, Gerald Nepom, John Gebe, Helena Reijonen, Andrew Liu
  • Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment
    Patent number: 7094555
    Abstract: The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: August 22, 2006
    Assignee: Benaroya Research Institute at Virginia Mason
    Inventors: William W. Kwok, Gerald Nepom, John Gebe, Helena Reijonen, Andrew Liu
  • Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment
    Publication number: 20030073102
    Abstract: The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
    Type: Application
    Filed: April 5, 2002
    Publication date: April 17, 2003
    Applicant: Virginia Mason Research Center
    Inventors: William W. Kwok, Gerald Nepom, John Gebe, Helena Reijonen, Andrew Liu
  • Sp.alpha.: a novel scavenger receptor cysteine-rich domain-containing polypeptide, and monoclonal antibodies thereto
    Patent number: 6046314
    Abstract: A new polypeptide from the scavenger receptor cysteine-rich family, termed Sp.alpha. herein, as well as polynucleotides encoding Sp.alpha. and methods of recombinantly producing the same, are disclosed. In addition, antibodies reactive with Sp.alpha. are provided, as are methods of using antibodies that bind to Sp.alpha. for modulating the interaction between Sp.alpha. and its receptor. Immunoassay kits containing the anti-Sp.alpha. antibodies are also provided.
    Type: Grant
    Filed: March 4, 1998
    Date of Patent: April 4, 2000
    Assignee: Bristol-Myers Squibb Co.
    Inventors: John A. Gebe, Anthony W. Siadak, Alejandro A. Aruffo