Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of ACC1 or ACC2 or both in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.

Abstract: A mechanically attached snowboard with a plurality of snow removal elements attached to its top surface that allows a snowboarder to remove compact snow and ice from the bottom on his or her boot before placing the boot into the binding or act as a temporary traction device for the detached rear boot. Each removal element includes an adapter adhesively attached and particularly embedded into the snowboard. Each adapter includes a threaded bore that is designed to receive a threaded bolt attached to a conical cap. During use, the conical cap extends above the top surface of the snowboard and scrapes away snow and ice located in the treads formed on the bottom of the snowboarder's boot. In the preferred embodiment, a plurality of adapters and caps are aligned on the top surface of the snowboard so that the entire lower surface of the boot can be easily cleaned by stomping or swiping the bottom surface of the boot thereover.