Patents by Inventor John Gillies
John Gillies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965026Abstract: The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.Type: GrantFiled: June 20, 2017Date of Patent: April 23, 2024Assignee: KYMAB LIMITEDInventors: Jamie Campbell, Nikole Sandy, Cassandra Van Krinks, Stephen John Arkinstall, Volker Germaschewski, Ian Kirby, Miha Kosmac, Thomas Gallagher, Cecilia Deantonio, Stephen Douglas Gillies
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Patent number: 9435093Abstract: In one embodiment, the present disclosure provides an engineered roughness element. In another embodiment, the present disclosure provides an array of engineered roughness elements. The engineered roughness elements are configured to reduce sand movement and accompanying dust generation.Type: GrantFiled: October 31, 2014Date of Patent: September 6, 2016Assignee: Board of Regents of the Nevada System of Higher Education, on behalf of the Desert Research InstituteInventors: Vicken Etyemezian, John Gillies
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Publication number: 20150117964Abstract: In one embodiment, the present disclosure provides an engineered roughness element. In another embodiment, the present disclosure provides an array of engineered roughness elements. The engineered roughness elements are configured to reduce sand movement and accompanying dust generation.Type: ApplicationFiled: October 31, 2014Publication date: April 30, 2015Applicant: Board of Regents of the Nevada System of Higher Edu., on behalf of the Desert Research InstituteInventors: Vicken Etyemezian, John Gillies
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Patent number: 8815566Abstract: Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ?-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.Type: GrantFiled: July 17, 2013Date of Patent: August 26, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Howard Glenn Damude, Peter John Gillies, Daniel Joseph Macool, Stephen K Picataggio, Dana M. Walters Pollak, James John Ragghianti, Zhixiong Xue, Narendra S Yadav, Hongxiang Zhang, Quinn Qun Zhu
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Patent number: 8685682Abstract: An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil fraction is described. This strain comprises various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprises various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of DHA. Production host cells are claimed, as are methods for producing DHA within said host cells.Type: GrantFiled: May 14, 2009Date of Patent: April 1, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Howard Glenn Damude, Peter John Gillies, Daniel Joseph Macool, Stephen K Picataggio, James John Ragghianti, John E Seip, Zhixiong Xue, Narendra S Yadav, Hongxiang Zhang, Quinn Qun Zhu
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Publication number: 20140030772Abstract: Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ?-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.Type: ApplicationFiled: July 17, 2013Publication date: January 30, 2014Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: Howard Glenn Damude, Peter John Gillies, Daniel Joseph Macool, Stephen K. Picataggio, Dana M. Walters Pollak, James John Ragghianti, Zhixiong Xue, Narendra S. Yadav, Hongxiang Zhang, Quinn Qun Zhu
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Publication number: 20130261180Abstract: Methods are provided for maintaining or lowering lipoprotein-associated phospholipase A2 [“Lp-PLA2”] levels, stabilizing rupture prone-atherosclerotic lesions, decreasing the Inflammatory Index and increasing Total Omega-3 Score™ in humans, by administering an effective amount of eicosapentaenoic acid [“EPA”], an omega-3 polyunsaturated fatty acid [“PUFA”].Type: ApplicationFiled: May 24, 2013Publication date: October 3, 2013Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: Peter John Gillies, Ernst John Schaefer
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Patent number: 8518674Abstract: Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ?-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.Type: GrantFiled: September 29, 2010Date of Patent: August 27, 2013Assignee: E I du Pont de Nemours and CompanyInventors: Howard Glenn Damude, Peter John Gillies, Daniel Joseph Macool, Stephen K. Picataggio, Dana M. Walters Pollak, James John Ragghianti, Zhixiong Xue, Narendra S. Yadav, Hongxiang Zhang, Quinn Qun Zhu
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Publication number: 20110178105Abstract: Methods are provided for maintaining or lowering lipoprotein-associated phospholipase A2 [“Lp-PLA2”] levels, stabilizing rupture prone-atherosclerotic lesions, decreasing the Inflammatory Index and increasing Total Omega-3 Score™ in humans, by administering an effective amount of eicosapentaecnoic acid [“EPA”], an omega-3 polyunsaturated fatty acid [“PUFA”].Type: ApplicationFiled: January 10, 2011Publication date: July 21, 2011Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: PETER JOHN GILLIES, Ernst John Schaefer
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Patent number: 7932077Abstract: Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ?-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.Type: GrantFiled: November 2, 2005Date of Patent: April 26, 2011Assignee: E. I. du Pont de Nemours and CompanyInventors: Howard Glenn Damude, Peter John Gillies, Daniel Joseph Macool, Stephen K. Picataggio, Dana M. Walters Pollak, James John Ragghianti, Zhixiong Xue, Narendra S. Yadav, Hongxiang Zhang, Quinn Qun Zhu
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Publication number: 20110086919Abstract: Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ?-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.Type: ApplicationFiled: September 29, 2010Publication date: April 14, 2011Applicant: E. I. Du Pont De Nemours and CompanyInventors: Howard Glenn Damude, Peter John Gillies, Daniel Joseph Macool, Stephen K. Picataggio, Dana M. Walters Pollak, James John Ragghianti, Zhixiong Xue, Narendra S. Yadav, Hongxiang Zhang, Quinn Qun Zhu
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Publication number: 20100022647Abstract: Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an ?-6 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases, and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of ARA. Production host cells are claimed, as are methods for producing ARA within said host cells.Type: ApplicationFiled: July 30, 2009Publication date: January 28, 2010Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Howard Glenn Damude, Peter John Gillies, Daniel Joseph Macool, Stephen K. Picataggio, Dana M. Walters Pollak, James John Ragghianti, Zhixiong Xue, Narendra S. Yadav, Hongxiang Zhang, Quinn Qun Zhu
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Publication number: 20090311380Abstract: An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil fraction is described. This strain comprises various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprises various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of DHA. Production host cells are claimed, as are methods for producing DHA within said host cells.Type: ApplicationFiled: May 14, 2009Publication date: December 17, 2009Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Howard Glenn Damude, Peter John Gillies, Daniel Joseph Macool, Stephen K. Picataggio, James John Ragghianti, John E. Seip, Zhixiong Xue, Narendra S. Yadav, Hongxiang Zhang, Quinn Qun Zhu
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Patent number: 7588931Abstract: Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an ?-6 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases, and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of ARA. Production host cells are claimed, as are methods for producing ARA within said host cells.Type: GrantFiled: November 1, 2005Date of Patent: September 15, 2009Assignee: E. I. du Pont de Nemours and CompanyInventors: Howard Glenn Damude, Peter John Gillies, Daniel Joseph Macool, Stephen K. Picataggio, Dana M. Walters Pollak, James John Ragghianti, Zhixiong Xue, Narendra S. Yadav, Hongxiang Zhang, Quinn Qun Zhu
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Patent number: 6202099Abstract: An approach for providing communication between sub-applications in a vertical application involves exchanging messages between sub-applications in a predetermined common message format referred to herein as a “common view.” Messages transmitted by sub-applications in message formats supported by the sub-applications are translated to produce messages in the common view. Messages to be received by sub-applications in the common view are translated to produce messages in the formats supported by the sub-applications. An adapter may be attached to each sub-application. The adapter provides for the translation of messages between a message format supported by the sub-application to which it is attached and the common view. An agent/broker architecture may be used in which agents are configured with metadata.Type: GrantFiled: March 30, 1998Date of Patent: March 13, 2001Assignee: Oracle CorporationInventors: John Gillies, David Nitz
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Patent number: 5356402Abstract: A reusable pad for the absorption, dispersion and retention of a liquid comprises an interior layer of hydrophobic material for receiving the liquid, a median layer consisting of a non-woven web of carded and cross-laid viscose rayon fibres and an outer layer of substantially waterproof polyurethane film. The fibres of the median layer have a cross-section of substantially rigid multilimbed configuration. The web is stitchbonded to form a cohesive layer for dispersing and absorbing the liquid. The web is stitchbonded with a thread under medium tension whereby uniform absorption characteristics are retained throughout said web. The interior layer, median layer and outer layer are joined to form a pad of unitary construction and capable of being washed for reuse.Type: GrantFiled: April 30, 1993Date of Patent: October 18, 1994Inventors: Suzanne Gillies, John Gillies
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Patent number: 5267991Abstract: A reusable diaper pad is disclosed for the absorption, dispersion and retention of a liquid. The pad comprises an interior layer of hydrophobic material for receiving the liquid, a median layer consisting of non-woven webs of carded and cross-laid viscose rayon fibres having a cross-section of substantially rigid multilimbed configuration with the webs being stitchbonded to form a cohesive layer for dispersing and absorbing the liquid and an outer layer of a substantially waterproof polyurethane film. The interior layer, median layer and outer layer are joined to form a pad of unitary construction and capable of being washed for reuse.Type: GrantFiled: February 5, 1991Date of Patent: December 7, 1993Inventors: Suzanne Gillies, John Gillies