Abstract: Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.

Abstract: This invention is directed to a medical device having a longitudinal axis, and including a handle and a catheter. The handle can include a body having a proximal end and a distal end, an actuator moveably coupled to the body, and a handle control member coupled to the actuator, wherein the actuator can be configured to move relative to the body to move the handle control member. The catheter can include a shaft having a proximal end and a distal end, wherein the proximal end of the shaft and the distal end of the body can be configured for releasable coupling. The catheter can also include a steering section located along the shaft and a catheter control member coupled to the steering section, wherein the catheter control member can be configured to move relative to the shaft to move the steering section relative to the longitudinal axis.

Abstract: Cell culture media are provided herein as are methods of using the media for cell culture and protein production from cells.

Abstract: A system, apparatus, and product for allowing access to a partially replicated dataset, including: detecting, by a target storage system, that a dataset will be replicated from a source storage system to the target storage system; exposing, by the target storage system, the dataset for user operations prior to receiving the entire dataset; receiving, by the target storage system, a request to read a portion of the dataset that has not been received by the target storage system; and retrieving, by the target storage system, the portion of the dataset.

Abstract: This invention is directed to a medical device having an elongate shaft having a distal end and a controller coupled to the shaft. A control member can extend through at least part of the elongate shaft and at least part of the controller, wherein the control member in a tensioned configuration can be moveable by the controller to control the distal end of the shaft and the control member can be slack in an untensioned configuration. A tensioning mechanism can be configured to move relative to at least one of the elongate shaft and the controller to tension the control member and automatically lock the control member in the tensioned configuration.

Abstract: This invention is directed to a medical device having a longitudinal axis, and including a handle and a catheter. The handle can include a body having a proximal end and a distal end, an actuator moveably coupled to the body, and a handle control member coupled to the actuator, wherein the actuator can be configured to move relative to the body to move the handle control member. The catheter can include a shaft having a proximal end and a distal end, wherein the proximal end of the shaft and the distal end of the body can be configured for releasable coupling. The catheter can also include a steering section located along the shaft and a catheter control member coupled to the steering section, wherein the catheter control member can be configured to move relative to the shaft to move the steering section relative to the longitudinal axis.

Abstract: Utilizing different data compression algorithms based on characteristics of a storage system, including: selecting, in dependence upon a priority for conserving processing resources or storage resources in a storage system, a data compression algorithm to utilize to compress data; detecting that at least one of an amount of processing resources available in the storage system or the amount of space available to store additional data in the storage system has changed; and responsive to detecting that at least one of the amount of processing resources available in the storage system or the amount of space available to store additional data in the storage system has changed, selecting a different data compression algorithm to utilize to compress data.

Abstract: A locking mechanism for a medical device to selective lock a first elongate member from longitudinal movement relative to a second elongate member of the medical device. The locking mechanism includes a flexible tubular member disposed in a bore of a handle assembly of the medical device, and an actuator, such as a cam member having a cam or eccentric surface. Pivotable movement of the actuator from a first position to a second position compresses or deforms the flexible tubular member against the first elongate member to lock the first elongate member from longitudinal movement relative to the handle assembly.

Abstract: A system and method for utilizing unmapped and unknown states in a storage system. When a first portion of a first medium is determined to be unreachable from any other mediums, the first portion of the first medium may be put into an unmapped state, and its data may be discarded and the corresponding storage locations may be freed. During replication of the first medium to a replica storage array, the state of the first portion of the first medium may be translated from the unmapped state into an unknown state on the replica storage array. If another storage array has the data of the first portion of the first medium, this data may be used to overwrite the first portion of the first medium on the replica storage array, converting the first portion of the first medium from the unknown state into the mapped state.

Abstract: The present disclosure is directed to a medical instrument. The medical instrument may include a delivery device and a retraction mechanism including a target tissue anchor and a first stabilizing anchor, wherein the target tissue anchor attaches to target tissue and connects to the delivery device.

Abstract: Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.

Abstract: Compressing data in dependence upon characteristics of a storage system, including: receiving an amount of processing resources available in the storage system; receiving an amount of space available in the storage system; and selecting, in dependence upon the priority for conserving the amount of processing resources and the amount of space, a data compression algorithm to utilize to compress the data.

Abstract: The present disclosure is directed to a medical instrument. The medical instrument may include a delivery device and a retraction mechanism including a target tissue anchor and a first stabilizing anchor, wherein the target tissue anchor attaches to target tissue and connects to the delivery device.

Abstract: A method, computing device and computer program product parse an electronic message and construct multiple differently prioritized messages. An electronic message is parsed to separately identify first and second differently formatted portions and the electronic message is analyzed to identify an action to be taken. In response to identification of a first action, a first message is constructed based upon the first portion to be transmitted to a first request processor and a first response is then received from the first request processor. A second message is constructed based upon the second portion. The method analyzes the first response and, when the first response is of a first type, causes the second message to be transmitted to a second request processor and based upon the second message, receives a second response from the second request processor. The method then constructs a response to the electronic message.

Abstract: A fastening mechanism that comprises an actuator, a fastening device attached to a distal end of the actuator, and a device coupler, wherein the fastening device is pivotally attached to the device coupler.

Abstract: A steerable device, such as a steerable catheter, may include a control handle and an insertion shaft extending outwardly therefrom. In use, the insertion shaft is navigated to an area of interest for examination and/or treatment thereof. The steerable device may include a steering system that controls the deflection angle of the distal end of the insertion shaft in two or more non-planar directions for navigating the insertion shaft to the area of interest. The steering system may also include a locking mechanism for arresting or partially arresting the movement of the distal end of the insertion shaft in a first direction independent of arresting or partially arresting the movement of the distal end in a second non-planar direction.

Abstract: Drive systems and methods of use are disclosed herein for performing medical procedures on a patient. The drive systems include various handle types and triggers for controlling catheters and end effectors. The various handle types include a flexible handle and ambidextrous handles that can alter the handedness of the handle for particularized use. The handles drive articulation sections of the catheter and end effectors with various degrees of freedom, and include locks for holding the catheter and/or end effector in place. The catheter systems include structures for allowing degrees of freedom, such as notches, mechanical interlocks, and articulation joints. In addition, the catheters articulate via cables or fluids.

Abstract: This invention is directed to a medical device having a longitudinal axis, and including a handle and a catheter. The handle can include a body having a proximal end and a distal end, an actuator moveably coupled to the body, and a handle control member coupled to the actuator, wherein the actuator can be configured to move relative to the body to move the handle control member. The catheter can include a shaft having a proximal end and a distal end, wherein the proximal end of the shaft and the distal end of the body can be configured for releasable coupling. The catheter can also include a steering section located along the shaft and a catheter control member coupled to the steering section, wherein the catheter control member can be configured to move relative to the shaft to move the steering section relative to the longitudinal axis.

Abstract: Drive systems and methods of use are disclosed herein for performing medical procedures on a patient. The drive systems include various handle types and triggers for controlling catheters and end effectors. The various handle types include a flexible handle and ambidextrous handles that can alter the handedness of the handle for particularized use. The handles drive articulation sections of the catheter and end effectors with various degrees of freedom, and include locks for holding the catheter and/or end effector in place. The catheter systems include structures for allowing degrees of freedom, such as notches, mechanical interlocks, and articulation joints. In addition, the catheters articulate via cables or fluids.

Abstract: A system for treating tissue includes an applicator and a clip assembly. The applicator includes a catheter extending longitudinally and a lumen extending therethrough, a control member extending through the lumen of the catheter. The assembly is releasably coupleable to a distal end of the applicator. The assembly includes a pair of clip arms, proximal ends of which are slidably received within a channel of a capsule, a pair of opposing coupling elements extending proximally from the proximal ends of the arms to be fixed over the distal end of the member so that the arms are movable relative to the capsule via a longitudinal motion of the member between a tissue receiving configuration, in which distal ends of the arms are separated from one another, and a tissue clipping configuration, in which distal ends of the arms are moved toward one another.