Abstract: The present invention discloses synthetic oligonucleotides complementary to contiguous and noncontiguous regions of the HBV RNA. Also disclosed are methods and kits for inhibiting the replication and expression of HBV, and for treating HBV infections and associated conditions.

Abstract: Inhibition of replication of an infectious agent, gene expression of an infectious agent, or both, by administration of an oligonucleotide complementary to highly conserved regions of the infectious agent is described.

Abstract: Inhibition of replication of an infectious agent, gene expression of an infectious agent, or both, by administration of an oligonucleotide complementary to highly conserved regions of the infectious agent is described. Inhibition of replication of a virus, gene expression of a virus, or both, by administration of an oligonucleotide complementary to highly conserved regions of the virus is also described.

Abstract: The present invention provides methods for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme having a flanking sequence modified to contain 2′-O-substituted nucleotides. The invention also provides ribozymes comprising a flanking sequence modified to contain 2′-O-substituted nucleotides. In addition, the invention provides methods for increasing ribozyme catalytic activity comprising contacting an RNA molecule with a ribozyme having a flanking sequence modified to contain a 2′-O-substituted nucleotide and a facilitator oligonucleotide. The present invention further provides compositions comprising a ribozyme having modified flanking sequences and an effective amount of a facilitator oligonucleotide.

Abstract: The present invention discloses synthetic oligonucleotides complementary to a nucleic acid spanning the translational start site of human papillomavirus gene E1, and including at least 15 nucleotides. Also disclosed are methods and kits for inhibiting the replication of HPV, for inhibiting the expression of HPV nucleic acid and protein, for detection of HPV, and for treating HPV infections.

Abstract: The present invention discloses synthetic oligonucleotides complementary to a nucleic acid spanning the translational start site of human papillomavirus gene E1, and including at least 15 nucleotides. Also disclosed are methods and kits for inhibiting the replication of HPV, for inhibiting the expression of HPV nucleic acid and protein, for detection of HPV, and for treating HPV infections.

Abstract: The present invention discloses synthetic oligonucleotides complementary to a nucleic acid spanning the translational start site of human papillomavirus gene E1, and including at least 15 nucleotides. Also disclosed are methods and kits for inhibiting the replication of HPV, for inhibiting the expression of HPV nucleic acid and protein, for detection of HPV, and for treating HPV infections.

Abstract: The present invention discloses synthetic oligonucleotides complementary to contiguous and non-contiguous regions of the HCV RNA. Also disclosed are methods and kits for inhibiting the replication of HCV, inhibiting the expression of HCV nucleic acid and protein, and for treating HCV infections.

Abstract: The present invention discloses synthetic oligonucleotides complementary to a nucleic acid spanning the translational start site of human papillomavirus gene E1, and including at least 15 nucleotides. Also disclosed are methods and kits for inhibiting the replication of HPV, for inhibiting the expression of HPV nucleic acid and protein, for detection of HPV, and for treating HPV infections.

Abstract: The present invention discloses synthetic oligonucleotides complementary to a nucleic acid spanning the translational start site of human papillomavirus gene E1, and including at least 15 nucleotides. Also disclosed are methods and kits for inhibiting the replication of HPV, for inhibiting the expression of HPV nucleic acid and protein, for detection of HPV, and for treating HPV infections.

Abstract: The present invention provides methods for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme having a flanking sequence modified to contain 2′-O-substituted nucleotides. The invention also provides ribozymes comprising a flanking sequence modified to contain 2′-O-substituted nucleotides. In addition, the invention provides methods for increasing ribozyme catalytic activity comprising contacting an RNA molecule with a ribozyme having a flanking sequence modified to contain a 2′-O-substituted nucleotide and a facilitator oligonucleotide. The present invention further provides compositions comprising a ribozyme having modified flanking sequences and an effective amount of a facilitator oligonucleotide.

Abstract: Methods are disclosed for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme and a 2'-O-substituted facilitator oligonucleotide. The present invention further provides compositions comprising a ribozyme and an effective amount of a 2'-O-methyl substituted facilitator oligonucleotide. The use of a facilitator, particularly a 2'-O-substituted facilitator, and more especially a 2'-O-methyl substituted facilitator, greatly enhances ribozyme catalytic activity, frequently making an otherwise inactive ribozyme active.

Abstract: The present invention discloses synthetic oligonucleotides complementary to contiguous and noncontiguous regions of the HBV RNA. Also disclosed are methods and kits for inhibiting the replication and expression of HBV, and for treating HBV infections and associated conditions.

Abstract: A device for transmitting digital packetized video and audio data is disclosed. The transmitter includes a video encoder, a prioritizer, and a packetizer. The video encoder receives video signals and encodes the video signals into a digital video data stream including codewords. The video encoder also generates motion vectors and fully intra-coded video frames for use by a video tape recorder during trick play operation. The prioritizer is coupled to the video encoder. The prioritizer receives the digital video data stream and prioritizes the video data according to a preselected prioritization scheme optimized for identifying data useful to video tape recorder trick play operation. The preselected prioritization scheme assigns the video codewords in the video data stream to a priority level according to the utility of each video codeword for video tape recorder recording and playback operation and outputs both the video codewords and a priority level signal.

Abstract: A digital video tape recorder ("VTR") that selects data useful for generating images during trick playback operation and records the data in trick play tape segments arranged on a tape to form fast scan tracks and multi-speed playback tracks. Each fast scan track comprises trick play tape segments located on a diagonal, relative to the length of the tape, of the same angle as the angle at which the heads of a VTR are expected to pass over the tape during trick play operation at a specific speed and direction of operation. Each multi-speed playback track comprises a plurality of trick play tape segments arranged parallel to the length of the tape. Data which is used for at least one mode of trick play operation is recorded in each trick play tape segment. Each fast scan track and multi-speed track crosses multiple normal play tracks.

Abstract: Method of operating a digital video tape recorder apparatus that receives encoded and packetized digital video data, depacketizes the received data and decodes the data to the extent necessary to select a subset of the data for use during trick play operation. In one embodiment, the digital video tape recorder includes a data prioritizer for prioritizing the video data according to a preselected prioritization scheme. The apparatus also includes an encoder and re-packetizer for forming the selected subset of received data into transport data packets. The received digital video data is recorded on a tape in tape locations from which data can be read during normal video tape recorder playback operation while the selected subset of the received data is recorded in tape locations from which data can be read during video tape recorder trick playback operation.

Abstract: Disclosed is a finderon having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. The finderon includes a rigid linker comprising at least one non-nucleotidic unit, flanked by first and second flanking regions of at least four contiguous, covalently-linked nucleotides. At least a portion of each flanking region is complementary to a target region on a substrate RNA molecule. Also disclosed are methods of preparing and using a finderon, and kits including a finderon.

Abstract: Methods of operating a digital video recording and playback device to identify trick play data, e.g., data that is intended for use during trick play modes of video playback device operation such as fast forward and reverse, by recording headers containing specific trick play information along with the trick play data are described. In one embodiment, the recording of headers which identify data as data intended for use during trick play as opposed to normal play operation is described. In addition to identifying data recorded data as normal play or trick play data headers associated with recorded data may identify the speed and direction of video tape recorder operation during which the specific data associated with the header is intended to be displayed at. When a data block includes data packets, a header may be used to identify various ones of the data packets as being for use during one mode of trick play operation, e.g.

Abstract: Disclosed are ribozyme analogs having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. The ribozyme analogs include a plurality of 3' to 5' covalently-linked nucleotides, and a rigid molecular linker having at least one non-nucleotidic molecule covalently linked to two of the nucleotides. Also disclosed are methods of preparing and utilizing the ribozyme analogs of the invention, and pharmaceutical formulations and kits containing such ribozyme analogs.

Abstract: Disclosed is a finderon having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. The finderon includes a rigid linker comprising at least one non-nucleotidic unit, flanked by first and second flanking regions of at least four contiguous, covalently-linked nucleotides. At least a portion of each flanking region is complementary to a target region on a substrate RNA molecule. Also disclosed are methods of preparing and using a finderon, and kits including a finderon.