Abstract: Various embodiments of layout tool devices and systems are provided. In various embodiments, the layout tool devices and systems improve layout work flow using layout tools, such as via using lasers and/or customized flexible elongate structures to facilitate marking points along a line, including systems with multiple devices, such as mobile devices, that emit lasers in combination with the other devices in the system.

Abstract: Methods and apparatus for providing delivery of content to client devices of a network via both multicast and unicast mechanisms. In one embodiment, a system for use in a managed content delivery network is described to bridge multicast to unicast, so that the total network bandwidth consumption is significantly lower than a corresponding unicast-only delivery solution, yet which still provides improved quality of service and user viewing experience as compared to a multicast-only delivery solution. In addition, various exemplary aspects of the present disclosure are readily adapted for real-time multicast to unicast streaming of audio and data to, among other things, minimize network bandwidth usage, while maintaining the guaranteed delivery of unicast streams with little or no modification to the existing client device logic.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: The present invention relates to engineered selectable marker proteins for recombinant protein expression, as well as novel expression vector designs for achieving high-level recombinant protein expression, and cells transfected therewith as a platform technology for producing extracellular vesicle-based therapeutic or prophylactic compositions, wherein one or more recombinant proteins of interest are displayed on the surface of the extracellular vesicles. As an example, the present invention relates to a virus-like article composition comprising such extracellular vesicles displaying one or more antigens configured to induce immune responses against SARS-CoV-2.

Abstract: The present invention relates to modular systems for vaccination against infectious agents that involves the delivery of, e.g., exosome-loaded, antigen-encoding mRNAs to and into cells and tissues of the immunized subject. The present invention also relates to compositions and methods for the design, preparation, manufacture, formulation, and/or use of vaccines, e.g., nucleic acid vaccines, loaded into extracellular vesicles, e.g., exosomes loaded with synthetic mRNAs encoding multiple surface and cytoplasmic antigens of interest, e.g., antigenic polypeptides derived from an infectious virus, e.g., SARS-CoV-2, designed to elicit strong humoral and cellular immune responses due to the simultaneous expression of antigens in their native state and as exosome-associated antigens.

Abstract: An oil and gas well shaped charge perforator capable of providing an exothermic reaction after detonation is provided, comprising a housing (2), a high explosive (3), and a reactive liner (6) where the high explosive is positioned between the reactive liner and the housing. The reactive liner (6) is produced from a reactive composition which is capable of sustaining an exothermic reaction during the formation of the cutting jet. The composition is a pressed i.e. compacted particulate composition comprising at least two metals, wherein one of the metals is present as spherical particulate, and the other metal is present as a non-spherical particulate. There may also be at least one further metal, which is not capable of an exothermic reaction with the reactive composition, present in an amount greater than 10% w/w of the liner. To aid consolidation a binder may also be added.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: An oil and gas well shaped charge perforator capable of providing an exothermic reaction after detonation is provided, comprising a housing (2), a high explosive (3), and a reactive liner (6) where the high explosive is positioned between the reactive liner and the housing. The reactive liner (6) is produced from a reactive composition which is capable of sustaining an exothermic reaction during the formation of the cutting jet. The composition is a pressed i.e. compacted particulate composition comprising at least two metals, wherein one of the metals is present as spherical particulate, and the other metal is present as a non-spherical particulate. There may also be at least one further metal, which is not capable of an exothermic reaction with the reactive composition, present in an amount greater than 10% w/w of the liner. To aid consolidation a binder may also be added.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: An oil and gas well shaped charge perforator capable of providing an exothermic reaction after detonation is provided, comprising a housing (2), a high explosive (3), and a reactive liner (6) where the high explosive is positioned between the reactive liner and the housing. The reactive liner (6) is produced from a reactive composition which is capable of sustaining an exothermic reaction during the formation of the cutting jet. The composition is a pressed i.e. compacted particulate composition comprising at least two metals, wherein one of the metals is present as spherical particulate, and the other metal is present as a non-spherical particulate. There may also be at least one further metal, which is not capable of an exothermic reaction with the reactive composition, present in an amount greater than 10% w/w of the liner. To aid consolidation a binder may also be added.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: An oil and gas well shaped charge perforator capable of providing an exothermic reaction after detonation is provided, comprising a housing (2), a high explosive (3), and a reactive liner (6) where the high explosive is positioned between the reactive liner and the housing. The reactive liner (6) is produced from a reactive composition which is capable of sustaining an exothermic reaction during the formation of the cutting jet. The composition is a pressed i.e. compacted particulate composition comprising at least two metals, wherein one of the metals is present as spherical particulate, and the other metal is present as a non-spherical particulate. There may also be at least one further metal, which is not capable of an exothermic reaction with the reactive composition, present in an amount greater than 10% w/w of the liner. To aid consolidation a binder may also be added.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: A method of detecting impending analytical failure in a networked diagnostic clinical analyzer is based upon detecting whether the operation of a particular analyzer is statistically distinguishable based on one or more thresholds. A failure occurs when one or more components or modules of the analyzer fails. A method to detect such an impending failure is disclosed. Baseline data on a pre-selected set of analyzer variables for a population of diagnostic clinical analyzers is used to generate an impending failure threshold. Subsequently, operational data comprising the same pre-selected set of analyzer variables allows generation of a time series of operational statistics. If the operational statistic exceeds the impeding failure threshold in a prescribed manner, an impending analytical failure is predicted. Such detection of impending analytical failures facilitates intelligent scheduling of service for the analyzer in question to maintain high assay throughput and accuracy.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: An audio enhancement technique comprises a stereo audio source. The stereo audio source is split in two identical sound signals, with one of the split signals sent to a compare block and the other to an audio block. Output from the stereo audio source is fed to a stereo bus A block to create a processed audio. A bypass block for turning the processed audio on or off is provided. The output from the bypass block is fed to the compare block. The processed audio is outputted for use by user.

Abstract: An oil and gas well shaped charge perforator capable of providing an exothermic reaction after detonation is provided, comprising a housing (2), a high explosive (3), and a reactive liner (6) where the high explosive is positioned between the reactive liner and the housing. The reactive liner (6) is produced from a reactive composition which is capable of sustaining an exothermic reaction during the formation of the cutting jet. The composition is a pressed i.e. compacted particulate composition comprising at least two metals, wherein one of the metals is present as spherical particulate, and the other metal is present as a non-spherical particulate. There may also be at least one further metal, which is not capable of an exothermic reaction with the reactive composition, present in an amount greater than 10% w/w of the liner. To aid consolidation a binder may also be added.

Abstract: A method of detecting impending analytical failure in a networked diagnostic clinical analyzer is based upon detecting whether the operation of a particular analyzer is statistically distinguishable based on one or more thresholds. A failure occurs when one or more components or modules of the analyzer fails. A method to detect such an impending failure is disclosed. Baseline data on a pre-selected set of analyzer variables for a population of diagnostic clinical analyzers is used to generate an impending failure threshold. Subsequently, operational data comprising the same pre-selected set of analyzer variables allows generation of a time series of operational statistics. If the operational statistic exceeds the impeding failure threshold in a prescribed manner, an impending analytical failure is predicted. Such detection of impending analytical failures facilitates intelligent scheduling of service for the analyzer in question to maintain high assay throughput and accuracy.