Abstract: The invention provides new bicyclopentanyl compounds having the general formula (I), or a solvate or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, R4, and R5 are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: Encoding and decoding systems are described for the provision of high quality digital representations of audio signals with particular attention to the correct perceptual rendering of fast transients at modest sample rates. This is achieved by optimising downsampling and upsampling filters to minimise the length of the impulse response while adequately attenuating alias products that have been found perceptually harmful.

Abstract: Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2.

Abstract: The invention relates to an automated hand, such as a prosthetic hand. In one form, the automated hand may be fluid compatible. In one form, the automated hand may comprise features to reduce the risk of harm to motors and/or other sensitive components of the hand when subject to an impact. In one form, the hand may comprise a wrist joint configured to allow the hand to curl and flex and/or to rotate. In one form, one or more digits of the hand may be individually controlled. In one form the hand may include a thumb rotation locking mechanism. In one form the hand may be provided with removable grip plates. In one form, the hand may be configured for use as a training hand.

Abstract: A fitting has a first housing including a first body and a second body. The first body defines a first channel and a second channel, and second body defines a third channel that is co-planar with the first channel and a fourth channel that is co-planar with the first channel. First bearings are disposed within the first channel and the third channel, where the first bearings rotatably coupled the first housing to the second housing. Additionally, second bearings are disposed within the second channel and the fourth channel, the second bearings rotatably coupling the first housing to the second housing. A plug couples to the first housing, a gasket is disposed between the plug and the first housing, and a passage is defined at least in part by the first housing, the second housing, and the plug.

Abstract: A novel system and method for determining a viewing frustum for a wide angle camera system employs multiple detection sub-systems to detect the presence or occurrence of events and/or objects of interest within the entire captured field of view of the system and processes the results of those detection sub-systems in accordance with a Hierarchy of Interest to select a viewing frustum for providing a de-warped view of interest to a viewer. The Hierarchy of Interest can be predefined, or selected from a set of Hierarchies of Interest and/or can be adaptive is response to feedback from a viewer.

Abstract: A method, system, and computer program product that is configured to: receive inbound data; tag a plurality of data fields of the inbound data; execute at least one integration flow which transforms the inbound data with tagged data fields to transformed data with the tagged data fields; obscure values of the data fields in the transformed data based on the tagged data fields; and send outbound data which includes the transformed data with the obscured values of the data fields.

Abstract: Condensation or “rain-out” is a problem in medical circuits and previous attempts to manage and/or prevent rain-out have resulted in relatively expensive and/or difficult to manufacture medical circuit components. The subject patent provides an improved medical circuit component for managing rain-out. In particular the component may be an improved breathing tube, or insufflation system limb comprising a helically corrugated tube preferably incorporating a heater wire.

Abstract: A method, computer program product, and computer system are described for providing integration flows between endpoint systems. The method includes providing a delegation integration module for each of multiple disparate types of endpoint systems, wherein a delegation integration module for a type of endpoint system is configured to understand how to construct and coordinate integration artifacts in the endpoint system type. The method includes defining an integration flow with required endpoint systems. This integration flow includes generating required linked integration artifacts, injecting the integration artifacts into the relevant endpoint systems that are ready for execution, delegating integration tasks of the integration flow via the delegation integration modules to the required endpoint systems, and using the linked integration artifacts at the endpoint systems to carry out the integration tasks.

Abstract: A power end frame includes a housing and a face plate secured to the housing. During use, components of the power end frame, including the housing and the face plate, are subjected to large tensile stresses. This disclosure describes a method of imparting compressive stresses in the power end frame to resist these large tensile stresses.

Abstract: A wearable ophthalmic device may include a head-mounted light field display configured to generate a physical light field comprising a beam of light. Camera(s) on or in communication with the device may receive light from the surroundings, and a light field processor may determine, based on the light, left and right numerical light field image data describing image(s) to be displayed to the left and right eyes respectively. The left and/or right numerical light field image data can be modified to computationally introduce a shift based on a determined convergence point of the eyes, and the physical light field presented to the user can be generated corresponding to the modified numerical light field image data, e.g., to correct for a convergence deficiency of the eye(s).

Abstract: A table includes a plurality of legs, a work surface supported by the plurality of legs, a lower rail spaced apart from the work surface and extending between the plurality of legs, and a cable clip. The lower rail includes a channel disposed in an underside of the lower rail. The cable clip is receivable by the channel of the lower rail. The cable clip includes a deformable channel configured to receive wires.

Abstract: An immersion cooling system and methods for operating the system are described. The system includes a vessel configured to hold thermally conductive, condensable dielectric fluid; a pressure controller to reduce or increase an interior pressure of the vessel; a computer component to be at least partially submerged within the dielectric fluid; and a fluid circulation system to draw the dielectric fluid from a sump area of the vessel, pass the dielectric fluid through a filter and deliver the dielectric fluid to a bath area of the vessel.

Abstract: Disclosed herein is a method of treating Idiopathic Pulmonary Fibrosis (IPF). The method includes administering to a subject in need thereof the deuterium-enriched pirfenidone LYT-100 at a total daily dose from about 1650 mg to about 2500 mg.

Abstract: A headgear system and/or an interface assembly incorporating a headgear system that, in some configurations, is configured to transform from elasticated or “stretchy” behavior to “inelastic” behavior at least in response to normal or expected forces encountered during the intended therapy. In some configurations, upon fitment to the head of a user, the system automatically adjusts toward or to an appropriate size. A headgear portion or assembly for use in combination with a breathing apparatus in some configurations is at least substantially inelastic and is three dimensional in shape. The headgear portion or assembly can comprise a plastic core and a textile casing. The headgear, or part thereof, may also have integrally moulded labels, connectors, adjustment mechanisms and/or grips.

Abstract: In some embodiments, a humidification system includes a heater base having a heater plate, a humidification chamber, and circuit. The circuit can include various conduits, including an inspiratory conduit, expiratory conduit, Y-piece, patient conduit, and/or dry conduit. In use, the chamber contains a quantity of liquid. The heater base heats the heater plate, which in turn heats the liquid to a temperature that causes at least some of the liquid to become vapor, thereby humidifying the gases within the chamber. The gas is delivered to the patient via the inspiratory conduit. Various features can help control the system and ensure the patient receives gases having the desired conditions. These features can be used individually or in various combinations and subcombinations both in existing humidification systems and improved systems for respiratory humidification, laparoscopy, and other purposes.

Abstract: A wearable ophthalmic device is disclosed. The device may include a head-mounted light field display configured to generate a physical light field comprising a beam of light. The head-mounted light field display may direct the beam of light into a user's eye, thereby producing a retinal reflex. The device may also include a head-mounted photodetector array configured to receive the retinal reflex and to generate numerical image data. The device may also include a light field processor configured to control the light field display, to analyze the retinal reflex using the numerical image data, and to determine an optical prescription for the user's eye based on the analysis of the retinal reflex.

Abstract: A stent delivery system including an elongate shaft of a medical device, a stent selectively coupled to a distal portion of the elongate shaft, and a coupling mechanism for selectively coupling the stent to the elongate shaft by inserting a tab on one of the stent or the elongate shaft into an opening in the other of the stent or the elongate shaft. The tab may be deflected from a first position to a second position to disengage the tab from the opening.

Abstract: The invention provides new heterocyclic compounds having the general formula (I?), or a solvate or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: A headgear system and/or an interface assembly incorporating a headgear system that, in some configurations, is configured to transform from elasticated or “stretchy” behavior to “inelastic” behavior at least in response to normal or expected forces encountered during the intended therapy. In some configurations, upon fitment to the head of a user, the system automatically adjusts toward or to an appropriate size. A headgear portion or assembly for use in combination with a breathing apparatus in some configurations is at least substantially inelastic and is three dimensional in shape. The headgear portion or assembly can comprise a plastic core and a textile casing. The headgear, or part thereof, may also have integrally moulded labels, connectors, adjustment mechanisms and/or grips.