Abstract: An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocyte biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment.

Abstract: Rock slider and rock step assemblies are often desired additions for off-road vehicles, as they can provide both protection and functionality. Rock sliders assemblies described herein can be constructed from high-strength materials like reinforced steel or aluminum, shield the vehicle's lower body and undercarriage from impacts with rocks and other obstacles. They can distribute the force of collisions, preventing damage to critical components. Similarly, rock step assemblies can offer convenient access to the vehicle while being durable enough to withstand harsh off-road conditions. These assemblies can utilize advanced mounting systems that avoid drilling, preserving the vehicle's structural integrity and warranty. Some embodiments can utilize reinforced materials to ensure resilience against physical stresses and corrosion.

Abstract: A medical fastening adapter is detachably fastenable to a fastening section of a medical robot arranged within a sterile cover or barrier. The fastening adapter includes a support structure with an instrument interface. The fastening adapter also includes at least a first, a second, and a third geometric coupling structure designed for positive connection to the fastening section. An adjusting element is operable to change positions of at least the first, second, and third geometric coupling structures relative to one another so that in a first state, the fastening adapter is couplable to the fastening section, and in a second state, the fastening adapter is non-detachably fixed to the fastening section, such that the position of the fastening adapter is fixed relative to the fastening section via the first, second, and third coupling structures. A medical fastening system and a medical device can include the medical fastening adapter.

Abstract: Currently, some work vehicles and/or off-road vehicles come from the manufacturer lacking tow hooks—or even a strong point on the rear bumper assembly and/or the chassis to install a tow hook. A non-limiting example of this sort of vehicle is the Toyota Tundra. It is highly desirable for such a vehicle to be able to be towed by another vehicle and/or have connection points for recovery from stuck in a natural hazard like mud or water. A novel and improved sway bar bushing bracket with a tow hook design is disclosed. In particular, the manufacturer-installed sway bar bushing bracket may be replaced with a reinforced sway bar bushing bracket with an integrated tow hook that may serve as a more robust sway bar bushing bracket, as well as providing a strong connection point with a tow hook.

Abstract: A training system for developing tackle technique and tackle follow-up technique includes a combination on a field of a first padded tackling training apparatus for targeted training at a first level corresponding to a relatively low body height, a second padded tackling training apparatus for targeted training at a second level corresponding to a medial body height; and a third padded tackling training apparatus for targeted training at a third level corresponding a relatively high body height facilitates coaching of improved technique for tackling and follow-up technique in contact sports, particularly in American football. The system and apparatus enables technique at a targeted tackling height to be coached and has features to facilitate follow-up actions and thereby providing more effective and safe tackling at a range of targeted heights for use in game play.

Abstract: A computer housing assembly for computer components includes a housing, which defines an interior space and which comprises wood. The components of a computer are positionable in the housing. The housing has a first sidewall, which is open. Each aperture of a plurality of apertures is positioned in the housing and is allows for insertion of a respective component or a user interface of the respective component. Each mounting element of a plurality of mounting elements is attached to the housing and is used to mount a respective component of the computer to the housing. A door is hingedly attached to the housing and is positioned to selectively close the first sidewall.

Abstract: Currently, some work vehicles and/or off-road vehicles come from the manufacturer lacking tow hooks—or even a strong point on the rear bumper assembly and/or the chassis to install a tow hook. A non-limiting example of this sort of vehicle is the Toyota Tundra. It is highly desirable for such a vehicle to be able to be towed by another vehicle and/or have connection points for recovery from stuck in a natural hazard like mud or water. A novel and improved sway bar bushing bracket with a tow hook design is disclosed. In particular, the manufacturer-installed sway bar bushing bracket may be replaced with a reinforced sway bar bushing bracket with an integrated tow hook that may serve as a more robust sway bar bushing bracket, as well as providing a strong connection point with a tow hook.

Abstract: In a general aspect, a construction tool can include a template portion arranged in a first plane. The template portion can include a rectangular plate having a slot defined, the slot being angled with respect to an edge of the plate and configured to facilitate marking a cut line on a construction material. The construction tool can also include a base portion arranged in a second plane, the second plane being orthogonal to the first plane. The base portion can include a first portion disposed on a first side of the plate, and a second portion disposed on a second side of the plate of the template portion that is opposite the first side of the plate. The first portion of the base portion can have a first thickness, and the second portion of the base portion having a second thickness that is different than the first thickness.

Abstract: Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may implement a wakeword detection component to detect when captured speech includes a wakeword. A companion application installed on the device may implement a wakeword detection component trained using speech of a user of the device. If the DSP's wakeword detection component detects a wakeword in speech, the companion application's wakeword detection component may be used to determine whether the wakeword was spoken by the user of the device. If the companion application's wakeword detection component determines the user spoke the wakeword, audio data representing the speech may be sent to at least one server(s) for processing.

Abstract: A training system for developing tackle technique and tackle follow-up technique includes a combination on a field of a first padded tackling training apparatus for targeted training at a first level corresponding to a relatively low body height, a second padded tackling training apparatus for targeted training at a second level corresponding to a medial body height; and a third padded tackling training apparatus for targeted training at a third level corresponding a relatively high body height facilitates coaching of improved technique for tackling and follow-up technique in contact sports, particularly in American football. The system and apparatus enables technique at a targeted tackling height to be coached and has features to facilitate follow-up actions and thereby providing more effective and safe tackling at a range of targeted heights for use in game play.

Abstract: Techniques for processing input data for a detected user are described. Received image data is processed to identify an indicated user. Based on the user a machine learning model is implemented. The machine learning model is then used to process input data for a user input. An action is performed using the resulting output data.

Abstract: Currently, some work vehicles and/or off-road vehicles come from the manufacturer lacking tow hooks—or even a strong point on the rear bumper assembly and/or the chassis to install a tow hook. A non-limiting example of this sort of vehicle is the Toyota Tundra. It is highly desirable for such a vehicle to be able to be towed by another vehicle and/or have connection points for recovery from stuck in a natural hazard like mud or water. A novel and improved sway bar bushing bracket with a tow hook design is disclosed. In particular, the manufacturer-installed sway bar bushing bracket may be replaced with a reinforced sway bar bushing bracket with an integrated tow hook that may serve as a more robust sway bar bushing bracket, as well as providing a strong connection point with a tow hook.

Abstract: In a general aspect, a construction tool can include a template portion arranged in a first plane. The template portion can include a rectangular plate having a slot defined, the slot being angled with respect to an edge of the plate and configured to facilitate marking a cut line on a construction material. The construction tool can also include a base portion arranged in a second plane, the second plane being orthogonal to the first plane. The base portion can include a first portion disposed on a first side of the plate, and a second portion disposed on a second side of the plate of the template portion that is opposite the first side of the plate. The first portion of the base portion can have a first thickness, and the second portion of the base portion having a second thickness that is different than the first thickness.

Abstract: Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may implement a wakeword detection component to detect when captured speech includes a wakeword. A companion application installed on the device may implement a wakeword detection component trained using speech of a user of the device. If the DSP’s wakeword detection component detects a wakeword in speech, the companion application’s wakeword detection component may be used to determine whether the wakeword was spoken by the user of the device. If the companion application’s wakeword detection component determines the user spoke the wakeword, audio data representing the speech may be sent to at least one server(s) for processing.