Abstract: The present invention provides commercial processes for preparing 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates thereof.

Abstract: A method for facilitating the distribution of the flow of one or more streams within a bed vessel is provided. Disposed within the bed vessel are internal materials and structures including multiple operating zones. One type of operating zone can be a processing zone composed of one or more beds of solid processing material. Another type of operating zone can be a treating zone. Treating zones can facilitate the distribution of the one or more streams fed to processing zones. The distribution can facilitate contact between the feed streams and the processing materials contained in the processing zones.

Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Porcine Epidemic Diarrhea Virus (“PEDV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine PEDV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length PEDV genomes that can replicate efficiently in host animals and tissue culture.

Abstract: Aspects of this disclosure relate to various systems and methods for use in a regulated industry and using an SEC qualified stablecoin as a store of value and medium of exchange on a blockchain-based transaction network. The system includes a stablecoin blockchain system with a stablecoin blockchain framework, a stablecoin ecosystem, and a stablecoin blockchain transaction network. The stablecoin blockchain system facilitates transactions between stablecoin blockchain participants within the stablecoin ecosystem. The stablecoin ecosystem conducts transactions across a stablecoin blockchain transaction network and a distributed blockchain ledger.

Abstract: A method, computer program product, and computer system for receiving, by a computing device, a design scenario for execution on one or more internet based platforms. Seed data may be injected into the one or more internet based platforms during execution based upon, at least in part, the design scenario. Performance of the scenario may be monitored. A report may be generated based upon, at least in part, the performance.

Abstract: Aspects of the present invention may include systems and methods for intraocular lens selection using a formula and a deep learning machine to estimate the error of the formula. In an aspect, the disclosure provides a method for intraocular lens selection. The method may include obtaining at least two ocular measurement parameters and a lens selection parameter for an eye. The method may include determining an intraocular lens power based on a formula using the at least two ocular measurement parameters. The method may include determining an estimated error of the formula using a deep learning machine trained on verified post-operative results using intraocular lenses selected by the formula. The method may include adjusting the lens selection parameter based on the estimated. The method may include redetermining the intraocular lens power based on the formula and the adjusted lens selection parameter.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for intelligently dispatching vehicles to a vehicle service center to progress vehicles at a predefined rate through sequential stations of the vehicle service center. The disclosed systems can analyze services associated with vehicles. Based on the services, the disclosed systems can determine how to order, within a virtual queue, vehicles corresponding to the services. For example, the disclosed systems can predict a complexity associated with a service for a vehicle, and in turn, determine whether adding the vehicle to the service queue will allow the vehicle to move through a set of sequential stations in accordance with the predefined progression rate. In response, the disclosed systems can dispatch the vehicle, refrain from dispatching the vehicle, or otherwise dynamically respond to enable the vehicle to move through the set of sequential stations in accordance with the predefined progression rate.

Abstract: Aspects of this disclosure relate to various systems and methods for use in a regulated industry and using an SEC qualified stablecoin as a store of value and medium of exchange on a blockchain-based transaction network. The system includes a stablecoin blockchain system with a stablecoin blockchain framework, a stablecoin ecosystem, and a stablecoin blockchain transaction network. The stablecoin blockchain system facilitates transactions between stablecoin blockchain participants within the stablecoin ecosystem. The stablecoin ecosystem conducts transactions across a stablecoin blockchain transaction network and a distributed blockchain ledger.

Abstract: Retaining brackets to fixedly secure either a singular modular shelving unit or multiple modular shelving units are disclosed. The retaining brackets can prevent modular shelves from dislodging, by positioning the retaining bracket such that an opening on the retaining bracket aligns with a mounting location on a vertical member of the modular shelving unit, and a distance between a retaining surface of the retaining bracket and a top surface of the modular shelf is small enough to prevent dislodging of the modular shelf when the retaining bracket is installed. The retaining surface of the retaining brackets can vary depending on the configuration used to retain the modular shelf, as well as the embodiment of the retaining bracket used.

Abstract: Compounds are provided according to Formula (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein A, R1, and R5 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Abstract: A traffic obstruction early warning system installed in roadway locations with limited visibility or restricted line of sight to warn drivers approaching a hazardous road condition well in advance so that precautionary measures may be taken and thereby reduce the risk of the multiple vehicle involvement. Selected roadway locations for the system installations can be the location of past vehicle pile-ups, or at-risk locations. The system timely and cohesively integrates inputs from a plurality of roadway sensors and human reporting to deploy a variety of visible and audible alerts to approaching drivers, law enforcement, emergency responders, local hospitals, utility companies, vehicle apps, and others using a variety of communication modalities.

Abstract: Graphical user interface (GUI) systems and methods are described for operating mobile application modes during a real-time caregiving event. Triggering of a caregiving event may be detected and/or caregiving data may be generated.

Abstract: A fuel injector includes a nozzle body, at least one injection orifice formed through an injection end of the nozzle body, and a tubular valve disposed in a bore of the nozzle body that moves between open and closed positions. Apertures formed through a wall of the tubular valve permit fuel to flow freely between opposite ends and along an inner surface of the valve, regardless of any limitations imposed by an annular gap between the valve and nozzle body. The injector provides exceptionally high fuel flow rates without increasing valve lift or injection orifice size over conventional diesel fuel injectors, making it ideal for synthetic fuels such as DME.

Abstract: A desmodromic mechanism exhibits reciprocating motion of a pair of cam followers driven by a single cam. The mechanism is useful in a fuel pump that pressurizes a liquid for delivery to a fuel rail of a combustion engine. A desmodromic lever is symmetric about its rotational axis and maintains continuous contact between cam lobes and cam followers for the entirety of each rotational cycle. The mechanism is particularly useful in multi-piston pumps required to deliver higher than normal volumes of liquid fuel, as is the case with low energy density alternatives to diesel fuel.

Abstract: A “hierarchical symmetric key distribution” method, system, and apparatus (“HKDS”) is provided for a scalable and fundamentally secure solution for a security protocol for financial transactions, including the electronic payment industry. The security protocol can be used in conjunction with various message authentication code generators and extended output functions to derive unique symmetric keys which can be used to protect messaging and communications in the financial services industry. The security protocol, for example, provide a distributed key management protocol that generates unique transaction keys from a base terminal key, such that the terminal does not retain information that could be used to reconstruct the key once the transaction has been completed, the capture of the terminals state does not provide enough information to construct future derived keys, and the server can reconstruct the transaction key using a bonded number of cryptographic operations.

Abstract: Multi-tiered graphical user interface (GUI) systems and methods are described for interoperating between multiple mobile application modes during a real-time caregiving event. An expert GUI and a novice GUI are rendered having a an expert mode and an novice mode, respectively, that share a control state for passing operation between the expert mode and the novice mode. A triggering of a caregiving event is detected that causes the passing of the control state from the expert mode to the novice mode, and the rendering of a novice GUI in an interoperated sequence following rendering of the expert GUI. Caregiving data of a novice user is generated during the novice mode, wherein the novice GUI, as rendered during the novice mode, comprises a different interface compared with the expert GUI, and the novice GUI configured for manipulation by the novice user.

Abstract: A thermal management module may include a first compartment including one or more of a coolant pump, a coolant valve, and a coolant conduit. A conjoined second compartment may include one or more of a valve actuator, an electronic control module, a system pressure sensor, a temperature sensor, and a heat exchanger. In certain embodiments, the first compartment may be enclosed in a first modular enclosure and the conjoined second compartment may be separately enclosed within a second modular enclosure.

Abstract: Aspects disclosed in the detailed description include multi-level instruction scheduling in a processor. Related methods and systems are also disclosed. In one exemplary aspect, an apparatus is provided that comprises a scheduler circuit comprising a scheduling group circuit, a first selection circuit, and a second selection circuit. The scheduling group circuit comprising a plurality of groups of scheduling entries, each scheduling entry among the groups of scheduling entries each comprising an instruction portion and a ready portion, each group configured to have its scheduling entries written in-order. The scheduling group circuit is further configured to maintain group age information associated with each group of the plurality of groups. The first selection circuit is configured to select a first in-order ready entry from each group. The second selection circuit is configured to select the first in-order ready entry belonging to the oldest group based on the group age information for scheduling.

Abstract: Aspects of the present invention may include systems and methods for intraocular lens selection using a formula and a deep learning machine to estimate the error of the formula. In an aspect, the disclosure provides a method for intraocular lens selection. The method may include obtaining at least two ocular measurement parameters and a lens selection parameter for an eye. The method may include determining an intraocular lens power based on a formula using the at least two ocular measurement parameters. The method may include determining an estimated error of the formula using a deep learning machine trained on verified post-operative results using intraocular lenses selected by the formula. The method may include adjusting the lens selection parameter based on the estimated. The method may include redetermining the intraocular lens power based on the formula and the adjusted lens selection parameter.

Abstract: Aspects of this disclosure relate to various systems and methods for use in a regulated industry and using an SEC qualified stablecoin as a store of value and medium of exchange on a blockchain-based transaction network. The system includes a stablecoin blockchain system with a stablecoin blockchain framework, a stablecoin ecosystem, and a stablecoin blockchain transaction network. The stablecoin blockchain system facilitates transactions between stablecoin blockchain participants within the stablecoin ecosystem. The stablecoin ecosystem conducts transactions across a stablecoin blockchain transaction network and a distributed blockchain ledger.