Abstract: The present disclosure relates to compounds according to Formula I or a pharmaceutically acceptable salt and/or solvate thereof, as well as compositions including such compounds and uses thereof, where X1 is H, F, or Cl; X2 is NH or N—R3; one of R1 and R2 is H, halo, alkyl, alkenyl, alkynyl, cycloalkyl, or heterocyclyl, and the remaining one of R1 and R2 is aryl, heteroaryl, or non-aromatic heterocyclyl; and R3 is alkyl, cycloalkyl, alkylenyl, and non-aromatic heterocyclyl. Among other things, the present disclosure evidences compounds of the present disclosure penetrate the central nervous system allowing for treatment of central nervous system cancers.

Abstract: An expandable trial can include an inferior portion, a superior portion, and a middle expanding portion as well as load cells for monitoring the load on the trial. The trial may also include recesses on its lateral sides to provide spacing to accommodate a disc removal tool so tissue can be cleared monitoring load. In addition, neural foramen spacing can be monitoring to provide information about how much neural release has been achieved as the disc is cleaned and the spine is positioned and repositioned.

Abstract: An intake assembly for an internal combustion engine, includes an intake manifold including a first plenum and a plurality of intake runners, the first plenum including an air supply inlet, the intake runners configured to be couplable to a cylinder head of the engine for supplying an air-fuel mixture thereto, the intake manifold configured such that, in use, air is supplied from the air supply inlet to the intake runners via the first plenum; a plurality of fuel injectors, each arranged to inject a fuel into one of the intake runners; and a fuel rail coupled to the plurality of fuel injectors, the fuel rail including a fuel supply inlet, and configured to supply fuel from the fuel supply inlet to the plurality of fuel injectors, in use. The fuel rail is mounted to the first plenum.

Abstract: A system and method(s) to perform operations that include detecting user input that indicates use of a gaming machine. The operations further include gathering, in response to detection of the user input, prompt-related data. The prompt-related data can include any relevant or available information associated with use of, or a user of, the gaming machine. The operations further include generating, based on the prompt-related data, a prompt. The operations further include dynamically generating, via a machine learning model using the prompt, original gaming content. The operations further include presenting, via a presentation device of the gaming machine, the dynamically generated gaming content.

Abstract: Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.

Abstract: An internal combustion engine includes a plurality of cylinders, and a plurality of fuel injectors configured to inject a fuel into a respective cylinder of the plurality cylinders. The fuel injectors are received within a bore in a body of the engine and when in service are movable in relation to the body. A seal surrounds each fuel injector and extends between each injector and a peripheral region of the bore.

Abstract: Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.

Abstract: Techniques are described for determining a value metric for each of a plurality of payment cards, and recommending payment card(s) based on their respective value metrics. Implementations provide a recommendation engine that analyzes user data and card data, and recommends payment card(s) that may be suitable for a user. The engine consumes usage data and credit score and uses that information, along with characteristics of various available cards, to develop a value metric for each payment card that indicates how valuable owning the card would be to the particular user, such as how much money the user can expect to make or lose every year if they use the card as indicated, given the card's interest rate, rewards, fees, and so forth. The engine can rank the cards according to their value metrics, and the top-ranked card(s) are presented to the user as recommendations in a user interface.

Abstract: An internal combustion engine includes a plurality of cylinders, and a plurality of fuel injectors configured to inject a fuel into a respective cylinder of the plurality cylinders. The fuel injectors are received within a bore in a body of the engine and when in service are movable in relation to the body. A seal surrounds each fuel injector and extends between each injector and a peripheral region of the bore.

Abstract: A method of forming a fin configured for use with a water sports board. The method includes providing a mold having a mold cavity and a first insert pre-preg sheet each including structural strands bonded by a first resin material. The method further includes placing the first insert pre-preg sheet within the mold cavity. The method further includes injecting a third resin material under pressure into the mold cavity. The method further includes injecting a core substance only in the form of a gaseous material into the third resin material to form a unitary hollow volume within the third resin material.

Abstract: An intake assembly for an internal combustion engine, includes an intake manifold including a first plenum and a plurality of intake runners, the first plenum including an air supply inlet, the intake runners configured to be couplable to a cylinder head of the engine for supplying an air-fuel mixture thereto, the intake manifold configured such that, in use, air is supplied from the air supply inlet to the intake runners via the first plenum; a plurality of fuel injectors, each arranged to inject a fuel into one of the intake runners; and a fuel rail coupled to the plurality of fuel injectors, the fuel rail including a fuel supply inlet, and configured to supply fuel from the fuel supply inlet to the plurality of fuel injectors, in use. The fuel rail is mounted to the first plenum.

Abstract: A method of forming a fin configured for use with a water sports board. The method includes providing a mold having a mold cavity and first and second insert pre-preg sheets each including structural strands respectively bonded by first and second resin materials. The method further includes placing the insert pre-preg sheets within the mold cavity. The method further includes injecting a third resin material under pressure into the mold cavity between the first insert pre-preg sheet and the second insert pre-preg sheet to urge the first insert pre-preg sheet and the second insert pre-preg sheet away from each other and towards respective ones of the pair of mold cavity faces, and dispose the third resin material between the first insert pre-preg sheet and the second insert pre-preg sheet to space at least a portion of the first insert pre-preg sheet from the second insert pre-preg sheet.

Abstract: Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.

Abstract: Technologies for power-aware scheduling include a computing device that receives network packets. The computing device classifies the network packets by priority level and then assigns each network packet to a performance group bin. The packets are assigned based on priority level and other performance criteria. The computing device schedules the network packets assigned to each performance group for processing by a processing engine such as a processor core. Network packets assigned to performance groups having a high priority level are scheduled for processing by processing engines with a high performance level. The computing device may select performance levels for processing engines based on processing workload of the network packets. The computing device may control the performance level of the processing engines, for example by controlling the frequency of processor cores. The processing workload may include packet encryption. Other embodiments are described and claimed.

Abstract: Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.

Abstract: Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.

Abstract: A working machine having a base assembly including a ground engaging structure; an undercarriage connected to the ground engaging structure; a superstructure connected to the undercarriage; a working arm mounted to the superstructure; a connector connecting the undercarriage to the superstructure; and a drive arrangement located in the base assembly for moving the ground engaging structure to propel, in use, the working machine.

Abstract: An expandable trial can include an inferior portion, a superior portion, and a middle expanding portion as well as load cells for monitoring the load on the trial. The trial may also include recesses on its lateral sides to provide spacing to accommodate a disc removal tool so tissue can be cleared monitoring load. In addition, neural foramen spacing can be monitoring to provide information about how much neural release has been achieved as the disc is cleaned and the spine is positioned and repositioned.

Abstract: Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.

Abstract: An expandable trial can include an inferior portion, a superior portion, and a middle expanding portion as well as load cells for monitoring the load on the trial. The trial may also include recesses on its lateral sides to provide spacing to accommodate a disc removal tool so tissue can be cleared monitoring load. In addition, neural foramen spacing can be monitoring to provide information about how much neural release has been achieved as the disc is cleaned and the spine is positioned and repositioned.