Abstract: This invention relates to systems and methods for processing and visualizing data related to trading strategies for exchange-traded equities based upon real-time options data.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: A rotatable nacelle includes an engine inlet configured to receive air and an inlet air management system (IAMS). The IAMS includes a primary inlet configured to selectively allow air to flow into a duct associated with the engine air inlet via the primary inlet and a secondary inlet configured to selectively allow air to flow into the duct associated with the engine air inlet via the secondary inlet. The secondary inlet is configured to receive an air filter.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A system for externally cooling a radiation shielded cask containing heat-emitting high level radioactive waste such as spent nuclear fuel. The system includes the cask defining an internal cavity configured to hold an unshielded canister containing the spent nuclear fuel. An annular cooling water header extends circumferentially around the entire circumference of the cylindrical sidewall of the cask. The header comprises plural dispensing outlets which direct cooling water onto the cask, thereby wetting the entire sidewall of the cask. The cooling water provides an external heat sink for absorbing the heat emitted through the external wall surface of the cask generated by the spent nuclear fuel. In various embodiments, the cooling water header may have a continuous annular structure, or be formed by two or more header segments. The header may be supported directly from the cask by detachably mounted brackets.

Abstract: The disclosure provides a plasmid and a lentiviral vector system which may be used to generate lentiviral vector particles for use in transduction. The disclosed vector system and/or plasmid improves the transduction efficiency of the generated lentiviral vector particles and may be exploited to provide compositions for raising immune responses in animals and as vaccines.

Abstract: A system for externally cooling a radiation shielded cask containing heat-emitting high level radioactive waste such as spent nuclear fuel. The system includes the cask defining an internal cavity configured to hold an unshielded canister containing the spent nuclear fuel. An annular cooling water header extends circumferentially around the entire circumference of the cylindrical sidewall of the cask. The header comprises plural dispensing outlets which direct cooling water onto the cask, thereby wetting the entire sidewall of the cask. The cooling water provides an external heat sink for absorbing the heat emitted through the external wall surface of the cask generated by the spent nuclear fuel. In various embodiments, the cooling water header may have a continuous annular structure, or be formed by two or more header segments. The header may be supported directly from the cask by detachably mounted brackets.

Abstract: A device for monitoring one or more passenger seats of a vehicle, the device comprising: at least one sensor configured to monitor an occupancy status for each of the one or more seats; and a communication interface configured to receive reservation conditions for each of the one or more seats; wherein the device is configured to: display an occupancy condition for each of the one or more seats and a reservation condition for each of the one or more seats; and determine the occupancy condition for each of the one or more seats based on the occupancy status for each of the one or more seats over a predefined time period.

Abstract: A device for monitoring one or more passenger seats of a vehicle, the device comprising: at least one sensor configured to monitor an occupancy status for each of the one or more seats; and a communication interface configured to receive reservation conditions for each of the one or more seats; wherein the device is configured to: display an occupancy condition for each of the one or more seats and a reservation condition for each of the one or more seats; and determine the occupancy condition for each of the one or more seats based on the occupancy status for each of the one or more seats over a predefined time period.

Abstract: The invention provides novel compounds of formula (I) and their pharmaceutically acceptable salts, metabolites, isomers (e.g. stereoisomers) and prodrugs. Such compounds are effective in the treatment of infections caused by Gram-negative bacteria such as Acinetobacter baumannii. In formula (I), X is O, NR (where R is either H or C1-3 alkyl, e.g. CH3), or CH2; R3 is H, F, CI, Br, I, or CH3; R4 is H, or OH; R5 and R6 are independently selected from H and OH, or R5 and R6 together are ?O; R7 is H, F, CI, Br, I, or CH3; R8 is H, OH, or —OC(O)NR?2 (where each R? is independently H or C1-3 alkyl, e.g. CH3), preferably R8 is H, OH or —OC(O)NH2; R9 is a 5- or 6-membered, saturated or unsaturated, carbocyclic ring optionally substituted by one or more substituents, or R9 is an optionally substituted straight-chained or branched C1-6 alkyl group (e.g. C1-3 alkyl group); R10 is a straight-chained or branched C1-8 alkyl group (e.g.

Abstract: The machine is configured to perform an automated rapid plasma reagent (RPR) agglutination test or other agglutination test. The machine includes a sample rack with multiple sample locations thereon and a reagent rack for storing of reagent. A shaker assembly supports at least one microtiter plate or other well supporting structure thereon with a plurality of wells in the plate. An automated pipette accesses samples and reagent and deposits them within wells of the microtiter plate. The shaker assembly shakes multiple samples within the wells of the microtiter plate. Finally, a camera photographs the wells of the plate, preferably from above with a light source below and the plate at least partially transparent. The image is then analyzed in an automated fashion to determine whether a ring of contrast material has remained smooth indicative of a non-reactive sample or has agglutinated/clumped together indicative of a reactive sample.

Abstract: System and methods are provided for three-dimensional simulation of a water environment in which one or more individuals are positioned in or around the water environment and then randomly presented in actual or potential distress situations. One embodiment includes means for presenting a random water environment with one or more random individuals presented in actual or potential distress situations, means for permitting a system user to call attention to when the one or more individuals are in an actual or potential distress situation, and means for detecting the response time from when the actual or potential distress situation begins to when the user calls attention to the one or more individuals in such an actual or potential distress situation.

Abstract: This disclosure is directed to systems and methods for producing a target map for a computing device, such as a mobile device. A set of golf shot data may be obtained and may include shot location data from a plurality of users and associated with a hole on a golf course. A geographic region may be determined based on the shot location data. A subset of target locations may be calculated using a target score and the shot location data of the set of golf shot data. In some cases, the target score is par. A target map may be produced using the subset of target locations. A visual indicia of the target map may be displayed with an image depicting at least a portion of the hole on the golf course.

Abstract: A limb support fastening arrangement for fastening a limb support to a limb of a wearer is disclosed. The arrangement comprises a first and second fastening portion, the first portion comprising an inflatable chamber comprising an upper and lower chamber wall and a first fastener disposed proximate the upper chamber wall, the lower chamber wall being arranged in use, to extend proximate the limb of the wearer. The second portion similarly comprises an inflatable chamber comprising an upper and lower chamber wall and a second fastener disposed proximate the upper chamber wall, the lower chamber wall being arranged in use, to extend proximate the limb of the wearer. The fastener associated with the first portion is arranged to detachably couple with the fastener associated with the second portion to detachably couple the first and second portions together, by positioning the lower chamber wall of one portion over the upper chamber wall of the other portion.

Abstract: A discovery bundle component is applied in a virtual image deployed within a virtual environment, wherein the discovery bundle automatically discovers asset information about one or more application bundles applied to the virtual image. The discovery bundle component sends, to a discovery product service, the asset information wrapped with a trusted signed certificate for the discovery product service, wherein the discovery product service is located outside the virtual environment.

Abstract: The machine is configured to perform an automated rapid plasma reagent (RPR) agglutination test or other agglutination test. The machine includes a sample rack with multiple sample locations thereon and a reagent rack for storing of reagent. A shaker assembly supports at least one microtiter plate or other well supporting structure thereon with a plurality of wells in the plate. An automated pipette accesses samples and reagent and deposits them within wells of the microtiter plate. The shaker assembly shakes multiple samples within the wells of the microtiter plate. Finally, a camera photographs the wells of the plate, preferably from above with a light source below and the plate at least partially transparent. The image is then analyzed in an automated fashion to determine whether a ring of contrast material has remained smooth indicative of a non-reactive sample or has agglutinated/clumped together indicative of a reactive sample.

Abstract: Numerous embodiments concerning methods and apparatus for processing a workpiece are disclosed. In one embodiment, an electronic display device having a plurality of viewing elements is provided, wherein a viewing element includes a color element and at least one viewing element exhibits a bright pixel defect. The color element of the viewing element exhibiting the bright pixel defect can be darkened by irradiating the color element with at least one laser pulse having a pulse duration in a range from 1 ps to 40 ps.

Abstract: A discovery bundle component is applied in a virtual image deployed within a virtual environment, wherein the discovery bundle automatically discovers asset information about one or more application bundles applied to the virtual image. The discovery bundle component sends, to a discovery product service, the asset information wrapped with a trusted signed certificate for the discovery product service, wherein the discovery product service is located outside the virtual environment.

Abstract: A discovery bundle component is applied in a virtual image deployed within a virtual environment, wherein the discovery bundle automatically discovers asset information about one or more application bundles applied to the virtual image. The discovery bundle component sends, to a discovery product service, the asset information wrapped with a trusted signed certificate for the discovery product service, wherein the discovery product service is located outside the virtual environment.

Abstract: A discovery bundle component is applied in a virtual image deployed within a virtual environment, wherein the discovery bundle automatically discovers asset information about one or more application bundles applied to the virtual image. The discovery bundle component sends, to a discovery product service, the asset information wrapped with a trusted signed certificate for the discovery product service, wherein the discovery product service is located outside the virtual environment.