Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates therof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension, congestive heart failure and male erectile dysfunction.

Abstract: An apparatus is provided for positioning a workpiece with high accuracy and repeatably positioning the workpiece with similar accuracy while avoiding further manual alignment operations. Tapered pins, movable axially against a spring, are used to support a registration frame above the workpiece and allow attachment of the registration frame to the workpiece with high accuracy after initial manual positioning of the workpiece. After attachment of the registration frame to the workpiece, the use of similar, spring-loaded, tapered pins assures accuracy of positioning without further manual alignment. The axial motion of the pins is particularly advantageous during alignment of a plurality of workpieces in stacks and for processes requiring two-sided registration. During the alignment operation, a vacuum block is relatively movable on a base block and a workpiece immobilized on the vacuum block by a vacuum selectively applied to a portion thereof.

Abstract: A transparent insert holder of the type characterized by being adapted to receive and protect cards such as photographs, permits and the like. The insert holder includes first and second four-edged plastic cover sheets for forming front and back surfaces of the insert holder. The first plastic cover sheet has a predetermined-sized transparent window therein defined by a surrounding non-transparent area, and a four-edged, double-sided frame is provided for being positioned between the first and second plastic sheets for securing the first and second sheets to opposing front and back sides of the frame to form the holder. The frame has a pressure sensitive adhesive coating the frame on its front and back surface. The first cover sheet is secured to the frame by the pressure-sensitive adhesive to completely enclose one of the front or back surfaces of the frame.

Abstract: Described herein is a process for selectively preparing and interconverting polymorph salts of fosinopril, an antihypertensive agent that inhibits angiotensin converting enzyme. Each polymorph is prepared by mixing an alkali metal carrier, fosinopril, water and a keto and/or hydroxylic solvent and isolating the polymorph formed from the reaction mixture. The less exothermic polymorph A is formed when the water makes up more than about 0.2% of the water and solvents; at about 0.2% or less, the more exothermic polymorph B is formed.

Abstract: A transparent insert holder of the type characterized by being adapted to receive and protect cards such as photographs, permits and the like. The insert holder includes first and second four-sided plastic sheets for forming front and back sides of the insert holder and a four-sided double-sided adhesive frame for being adhesively positioned between said first and second plastic sheets for securing said first and second sheets together in to form the holder. The adhesive frame defines an opening for receiving a card such as a photograph or identification card therein.

Abstract: A method is provided for preparing phosphinic acid compounds, which are useful in preparing certain angiotensin converting enzyme inhibitors, which have the formula ##STR1## wherein R.sub.1 is lower alkyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl;R.sub.2 is hydrogen, lower alkyl or arylalkyl;X is hydrogen, lower alkyl or phenyl;Y is hydrogen, lower alkyl, phenyl or alkoxy, or together X and Y are --(CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 --, --CH.dbd.CH--, or ##STR2## and n is 0 or 1including salts thereof and stereoisomers thereof, which method includes the steps of reacting a phosphinic acid ester of the structure ##STR3## wherein R.sub.