Abstract: An aerosol composition with compressed gas propellant that is free of hydrocarbon propellants is described, wherein the composition comprises: 85.0 wt % to 98.0 wt % water; 0.01 wt % to 10.00 wt % low MW alcohol; 0.001 wt to 5.00 wt % surfactant; 0.001 wt to 5.00 wt % fragrance; 0.001 wt to 5.00 wt % borate salt; 0.001 wt to 5.00 wt % preservative.

Abstract: Nucleic acid mitochondrial delivery systems are provided. These systems are important for delivery of genetic information to a mitochondrion and for treatment of mitochondrial related diseases.

Abstract: Nucleic acid mitochondrial delivery systems are provided. These systems are important for delivery of genetic information to a mitochondrion and for treatment of mitochondrial related diseases.

Abstract: Compositions for suppressing and inhibiting mitochondrial oxidative stress. The compositions include a human mitochondrial superoxide dismutase (SOD2) gene. Methods of treating patients suffering from diseases or disorders associated with mitochondrial oxidative stress.

Abstract: A synthetic, nuclear-encoded ND4 gene was linked to a mitochondrial targeting sequence and a FLAG epitope tag. This fusion construct was inserted into a rAAV vector. The ND4 fusion protein was expressed and imported into the mitochondria of cells harboring a mitochondrial DNA mutation (G11778A), where it restored cellular respiration.

Abstract: An agile transparent network with a trail routing and switching (also called “engineering”) mechanism is provided that enables efficient use of regenerators and wavelengths available in the network, while maintaining a very efficient time-to-service. The trail engineering mechanism allows fast, automatic establishment of new connections based on the current network architecture, connectivity and loading and also on conditions in the connection request. Selection of regenerator sites and of the wavelengths used on each regenerator segment is performed with optimal use of current network resources, while ensuring that the quality of the selected trail is adequate for the respective call. The mechanism provides for both distance and performance balancing, and it optimizes the network response time.

Abstract: A synthetic, nuclear-encoded ND4 gene was linked to a mitochondrial targeting sequence and a FLAG epitope tag. This fusion construct was inserted into a rAAV vector. The ND4 fusion protein was expressed and imported into the mitochondria of cells harboring a mitochondrial DNA mutation (G11778A), where it restored cellular respiration.