Patents by Inventor John H. A. Butler

John H. A. Butler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRICYCLIC-AMIDO-BICYCLIC PRMT5 INHIBITORS
    Publication number: 20240124442
    Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.
    Type: Application
    Filed: February 3, 2022
    Publication date: April 18, 2024
    Applicant: AMGEN INC.
    Inventors: Albert AMEGADZIE, Diane Jennifer BEYLKIN, Shon BOOKER, Matthew Paul BOURBEAU, John R. BUTLER, Kevin Lloyd GREENMAN, Todd J. KOHN, Kexue LI, Qingyian LIU, Ana Elena MINATTI, Primali Vasundera NAVARATNE, Liping H. PETTUS, Rene RAHIMOFF, Hui-Ling WANG, Nicholas Anthony WEIRES
  • TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS
    Publication number: 20240101570
    Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).
    Type: Application
    Filed: November 22, 2021
    Publication date: March 28, 2024
    Inventors: Albert AMEGADZIE, Diane Jennifer BEYLKIN, Shon BOOKER, Matthew Paul BOURBEAU, John R. BUTLER, Sanne Ormholt Schroder GLAD, Todd J. KOHN, Brian Alan LANMAN, Kexue LI, Qingyian LIU, Patricia LOPEZ, Francesco MANONI, Primali Vasundera NAVARATNE, Liping H. PETTUS, Rene RAHIMOFF, Nuria A. TAMAYO, Mikkel VESTERGAARD, Hui-Ling WANG, Nicholas Anthony WEIRES
  • NOVEL PRMT5 INHIBITORS
    Publication number: 20240092794
    Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.
    Type: Application
    Filed: November 6, 2023
    Publication date: March 21, 2024
    Applicant: AMGEN INC.
    Inventors: Shon BOOKER, Matthew Paul BOURBEAU, John R. BUTLER, Sanne Ormholt Schroder GLAD, Brian Alan LANMAN, Patricia LOPEZ, Francesco MANONI, Liping H. PETTUS, Ian SARVARY, Nuria A. TAMAYO, Mikkel VESTERGAARD, Nicholas Anthony WEIRES
  • Deep submergence bender transduction apparatus
    Patent number: 11911793
    Abstract: A low frequency underwater sound electro-mechanical transduction bender apparatus for radiating sound at deep submergence depths and including at least one piezoelectric bilaminar or trilaminar beam or disc having opposed support ends; a pair of piezoelectric structures that each have sides that are respectively connected at the opposed support ends of the beam or disc. The piezoelectric bilaminar or trilaminar beam or disc is driven by the pair of piezoelectric structures. The apparatus further includes a housing that contains the piezoelectric bilaminar or trilaminar beam or disc and the pair of piezoelectric structures, as well as an internal fill of a fluid substance.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: February 27, 2024
    Assignee: Image Acoustics, Inc.
    Inventors: John L. Butler, Frank D. Fratantonio, Jethro H. Tannis
  • SYNTHESIS OF OLIGOMERS IN ARRAYS
    Publication number: 20160256844
    Abstract: Systems, including apparatus and methods, for synthesis of oligomers in arrays.
    Type: Application
    Filed: March 7, 2016
    Publication date: September 8, 2016
    Inventor: John H. BUTLER
  • Synthesis of oligomers in arrays
    Patent number: 9283535
    Abstract: Systems, including apparatus and methods, for synthesis of oligomers in arrays.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: March 15, 2016
    Assignee: Applied Biosystems, LLC
    Inventor: John H. Butler
  • Synthesis of Oligomers in Arrays
    Publication number: 20120035082
    Abstract: Systems, including apparatus and methods, for synthesis of oligomers in arrays.
    Type: Application
    Filed: October 20, 2011
    Publication date: February 9, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventor: John H. Butler
  • SYNTHESIS OF OLIGOMERS IN ARRAYS
    Publication number: 20110123411
    Abstract: Systems, including apparatus and methods, for synthesis of oligomers in arrays.
    Type: Application
    Filed: November 29, 2010
    Publication date: May 26, 2011
    Applicant: Life Technologies Corporation
    Inventor: John H. BUTLER
  • Synthesis of Oligomers in Arrays
    Publication number: 20100160185
    Abstract: Systems, including apparatus and methods, for synthesis of oligomers in arrays.
    Type: Application
    Filed: June 16, 2009
    Publication date: June 24, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventor: John H. Butler
  • Method and apparatus for in situ synthesis on a solid support
    Patent number: 6589726
    Abstract: The present invention relates to methods for fabricating solid supports. More specifically, the present invention features methods for fabricating solid supports for in situ synthesis and for carrying out large numbers of reactions. The present invention also features solid supports with in situ synthesized long polynucleotides.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: July 8, 2003
    Assignee: Metrigen, Inc.
    Inventors: John H. Butler, Thomas M. Brennan
  • Single use syringe
    Patent number: 4941879
    Abstract: A single use syringe having an interacting piston and cylinder which cooperate to define a variable volume working space, the syringe includes a valve body located in the chamber so as to divide the chamber into a first and second sub-chamber, the valve body has valves which permit a liquid to be initially drawn into the syringe and then injected, but prevent a subsequent liquid being drawn into the syringe.
    Type: Grant
    Filed: July 10, 1989
    Date of Patent: July 17, 1990
    Assignee: John H. A. Butler
    Inventors: John H. A. Butler, Sandy Richardson
  • Single use syringe
    Patent number: RE34335
    Abstract: A single use syringe .[.having.]. .Iadd.has .Iaddend.an interacting piston and cylinder which cooperate to define a variable volume working space.[.,.]..Iadd.; .Iaddend.the syringe includes a valve body located in the chamber so as to divide the chamber into a first and second sub-chamber, .Iadd.and .Iaddend.the valve body has valves which permit a liquid to be initially drawn into the syringe and then injected, but prevent a subsequent liquid being drawn into the syringe. .Iadd.A valve for the syringe is also claimed. .Iaddend.
    Type: Grant
    Filed: September 12, 1991
    Date of Patent: August 3, 1993
    Assignee: John Henry Adam Butler
    Inventors: John H. A. Butler, Alexander S. Richardson