Abstract: A bone stapler including a housing in which stapler can be driven by a driver along a passageway from an inlet to an outlet opening by activation of an operated drive means. Pointed projections are provided to locate bone portions to be stapled, manually releasable safety means is provided to prevent inadvertent driving of a staple, and the drive means is adopted to exhaust air at a location remote from the bone portion being stapled. Also a staple cartridge is provided that, when removed from the stapler, insures that no staple can remain in the stapler, and the stapler will accept different parts that receive the cartridge and define the passageway so that staples of different sizes may be driven.