Abstract: A method is presented for determining absolute intracranial pressure (ICP) in a patient. Skull expansion is monitored while changes in ICP are induced. The patient's blood pressure is measured when skull expansion is approximately zero. The measured blood pressure is indicative of a reference ICP value. Subsequently, the method causes a known change in ICP and measures the change in skull expansion associated therewith. The absolute ICP is a function of the reference ICP value, the known change in ICP and its associated change in skull expansion, and a measured change in skull expansion.

Abstract: A method and apparatus for measuring intracranial pressure. In one embodiment, the method comprises the steps of generating an information signal that comprises components (e.g., pulsatile changes and slow changes) that are related to intracranial pressure and blood pressure, generating a reference signal comprising pulsatile components that are solely related to blood pressure, processing the information and reference signals to determine the pulsatile components of the information signal that have generally the same phase as the pulsatile components of the reference signal, and removing from the information signal the pulsatile components determined to have generally the same phase as the pulsatile components of the reference signal so as to provide a data signal having components wherein substantially all of the components are related to intracranial pressure.

Abstract: A method and apparatus for measuring changes in intracranial pressure (ICP) utilizing the variation of the surface wave propagation parameters of the patient's skull to determine the change in ICP.

Abstract: A method is presented for determining diastolic intracranial pressure (ICP) in a patient. A first change in the length of a path across the skull of the patient caused by a known change in ICP is measured and used to determine an elasticity constant for the patient. Next, a second change in the length of the path across the patient's skull occurring between systolic and diastolic portions of the patient's heartbeat is measured. The patient's diastolic ICP is a function of the elasticity constant and the second change.

Abstract: An acoustic nonlinearity parameter (&bgr;) measurement method and system for Non-Destructive Evaluation (NDE) of materials and structural members novelly employs a loosely mounted dielectric electrostatic ultrasonic transducer (DEUT) to receive and convert ultrasonic energy into an electrical signal which can be analyzed to determine the &bgr; of the test material. The dielectric material is ferroelectric with a high dielectric constant ∈. A computer-controlled measurement system coupled to the DEUT contains an excitation signal generator section and a measurement and analysis section. As a result, the DEUT measures the absolute particle displacement amplitudes in test material, leading to derivation of the nonlinearity parameter (&bgr;) without the costly, low field reliability methods of the prior art.

Abstract: Non-invasive measuring devices responsive to changes in a patient's intracranial pressure (ICP) can be accurately calibrated for monitoring purposes by providing known changes in ICP by non-invasive methods, such as placing the patient on a tilting bed and calculating a change in ICP from the tilt angle and the length of the patient's cerebrospinal column, or by placing a pressurized skull cap on the patient and measuring the inflation pressure. Absolute values for the patient's pressure-volume index (PVI) and the steady state ICP can then be determined by inducing two known changes in the volume of cerebrospinal fluid while recording the corresponding changes in ICP by means of the calibrated measuring device. The two pairs of data for pressure change and volume change are entered into an equation developed from an equation describing the relationship between ICP and cerebrospinal fluid volume. PVI and steady state ICP are then determined by solving the equation.

Abstract: A system for and method of detecting and measuring concentrations of an ultrasonically-reflective microsphere contrast agent involving detecting non-linear sum and difference beat frequencies produced by the microspheres when two impinging signals with non-identical frequencies are combined by mixing. These beat frequencies can be used for a variety of applications such as detecting the presence of and measuring the flow rates of biological fluids and industrial liquids, including determining the concentration level of microspheres in the myocardium.

Abstract: The invention is a method of and apparatus for characterizing the amplitudes of a sequence of reflected pulses R.sub.1, R.sub.2, and R.sub.3 by converting them into corresponding electrical signals E.sub.1, E.sub.2, and E.sub.3 and thereafter exponentially adjusting the amplitudes of the respective signals E.sub.1, E.sub.2, and E.sub.3 to substantially the same value during each sequence thereby restoring the reflected pulses R.sub.1, R.sub.2, and R.sub.3 to their initial reflection values by means of timing means 12 and 13, an exponential generator 17 and a time gain compensator 18. Envelope and baseline reject circuits 23 and 24 respectively permit the display and accurate location of the time spaced sequence of electric signals having substantially the same amplitude on a measurement scale on a suitable video display or oscilloscope 14.

Abstract: Ultrasonic radio frequency toneburst are launched into a sample of material tested. The amplitude of the tone-bursts and the slope of the resulting static displacement pulses are measured. These measurement are used to calculate the nonlinearities of the material.

Abstract: A tracking generator 21 is slaved to a spectrum analyzer 23 to produce an input signal having a frequency that follows the frequency of the spectrum analyzer sweeping local oscillator 22. The input signal is gated to a transducer 26 by a transmitter gate 25 to produce ultrasonic waves in the sample 28. The resulting ultrasonic echoes are converted into electrical signals by the transducer and then gated into the spectrum analyzer by receiver gate 29. This arrangement produces spectra that are equivalent to shock-exciting the transducer with a true delta function shock-excitation.

Abstract: A broadband megahertz range electrostatic acoustic transducer for use in a liquid environment. A liquid-tight enclosure 11 which includes a metallic conducting membrane 18 as part of its outside surface has a means 19 inside the liquid-tight enclosure for applying a tension to the membrane and for mounting an electrode 23 such that the flat end of the electrode is approximately parallel to the membrane. The invention includes structure and a method for ensuring that the membrane 18 and the flat end of the electrode 23 are exactly parallel and a fixed predetermined distance from each other.

Abstract: This invention, a method for ultrasonically determining the depth of a skin burn, is based on the finding that the acoustical impedance of burned tissue differs sufficiently from that of live tissue to permit ultrasonic detection of the interface between the burn and the underlying unburned tissue. The method is simple, rapid, and accurate. As compared with conventional practice, it provides the important advantage of permitting much earlier determination of whether a burn is of the first, second, or third degree. In the case of severe burns, the usual two - to three-week delay before surgery may be reduced to about 3 days or less.