Patents by Inventor John H. Grate
John H. Grate has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110195465Abstract: The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.Type: ApplicationFiled: December 23, 2010Publication date: August 11, 2011Applicant: CODEXIS, INC.Inventors: Lorraine Joan Giver, Lisa Marie Newman, Emily Mundorff, Gjalt W. Huisman, Stephane J. Jenne, Jun Zhu, Behnaz Behrouzian, John H. Grate, James Lalonde
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Patent number: 7879585Abstract: The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.Type: GrantFiled: October 1, 2007Date of Patent: February 1, 2011Assignee: Codexis, Inc.Inventors: Lorraine Joan Giver, Lisa Marie Newman, Emily Mundorff, Gjalt W. Huisman, Stephane J. Jenne, Jun Zhu, Behnaz Behrouzian, John H. Grate, James Lalonde
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Patent number: 7807423Abstract: The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.Type: GrantFiled: August 10, 2006Date of Patent: October 5, 2010Assignee: Codexis, Inc.Inventors: S. Christopher Davis, John H. Grate, David R. Gray, John M. Gruber, Gjalt W. Huisman, Steven K. Ma, Lisa M. Newman, Roger Sheldon, Li A Wang
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Publication number: 20090118130Abstract: The present disclosure relates to compositions and methods for screening a plurality of polypeptide variants.Type: ApplicationFiled: February 12, 2008Publication date: May 7, 2009Applicant: Codexis, Inc.Inventors: Emily Mundorff, Simon Christopher Davis, Gjalt W. Huisman, Anke Krebber, John H. Grate
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Publication number: 20080248539Abstract: The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.Type: ApplicationFiled: October 1, 2007Publication date: October 9, 2008Applicant: Codexis, Inc.Inventors: Lorraine Joan Giver, Lisa Marie Newman, Emily Mundorff, Gjalt W. Huisman, Stephane J. Jenne, Jun Zhu, Behnaz Behrouzian, John H. Grate, James Lalonde
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Patent number: 7132267Abstract: The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.Type: GrantFiled: February 18, 2004Date of Patent: November 7, 2006Assignee: Codexis, Inc.Inventors: S. Christopher Davis, John H. Grate, David R. Gray, John M. Gruber, Gjalt W. Huisman, Steven K. Ma, Lisa M. Newman, Roger Sheldon, Li A Wang
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Patent number: 7125693Abstract: The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives.Type: GrantFiled: August 11, 2003Date of Patent: October 24, 2006Assignee: Codexis, Inc.Inventors: S. Christopher Davis, John H. Grate, David R. Gray, John M. Gruber, Gjalt W. Huisman, Steven K. Ma, Lisa M. Newman, Roger Sheldon, Li A Wang
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Publication number: 20040214297Abstract: The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.Type: ApplicationFiled: February 18, 2004Publication date: October 28, 2004Inventors: S. Christopher Davis, John H. Grate, David R. Gray, John M. Gruber, Gjalt W. Huisman, Steven K. Ma, Lisa M. Newman, Roger Sheldon, Li A. Wang
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Publication number: 20040137585Abstract: The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives.Type: ApplicationFiled: August 11, 2003Publication date: July 15, 2004Inventors: S. Christopher Davis, John H. Grate, David R. Gray, John M. Gruber, Gjalt W. Huisman, Steven K. Ma, Lisa M. Newman, Roger Sheldon, Li A. Wang
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Patent number: 6469181Abstract: The present invention provides a processes, having practical utility, for preparing 2-oxindoles, N-hydroxy-2-oxindoles, or mixtures thereof comprising: catalytically hydrogenating a 2-nitroarylmalonate diester to produce a 2-(N-hydroxyamino)arylmalonate diester, a 2-aminoarylmalonate diester, or mixtures thereof as a first reaction intermediate; cyclizing, by intramolecular aminolysis of one ester group, the first reaction intermediate to produce a N-hydroxy-2-oxindole-3-carboxylate ester, 2-oxindole-3-carboxylate ester, or mixtures thereof as a second reaction intermediate; and hydrolyzing and decarboxylating the remaining ester group of the second reaction intermediate to produce the N-hydroxy-2-oxindole, the 2-oxindole, or mixtures thereof, wherein the cyclization reaction and the hydrolysis and decarboxylation reaction are conducted in situ with the catalytic hydrogenation reaction without isolation of said reaction intermediates.Type: GrantFiled: January 30, 1995Date of Patent: October 22, 2002Assignee: Catalytica, Inc.Inventors: John M. Gruber, A. Ray Bulls, John H. Grate
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Patent number: 5792721Abstract: The present invention provides a process for the preparation of acidic aqueous solutions consisting essentially of, phosphomolybdovanadate salts. Certain processes of the present invention dissolve in water an oxide, oxoacid, or mixtures thereof, and at least one oxoanion salt of phosphorus, molybdenum, and vanadium, wherein the sum of salt cationic charges does not exceed the sum of the phosphomolybdovanadate anionic charges in the solution. Other processes of the present invention dissolve in water a) an oxide, oxoacid, oxoanion salt, or mixtures thereof of phosphorus, molybdenum, and vanadium and b) a carbonate salt, bicarbonate salt, hydroxide salt or mixtures thereof, wherein the sum of salt cationic charges does not exceed the sum of the phosphomolybdovanadate anionic charges in the solution.Type: GrantFiled: November 9, 1994Date of Patent: August 11, 1998Assignee: Catalytica, Inc.Inventors: John H. Grate, David R. Hamm, Robert J. Saxton
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Patent number: 5557014Abstract: The present invention provides aqueous catalyst solutions useful for oxidation of olefins to carbonyl products, comprising a palladium catalyst and a polyoxoacid or polyoxoanion oxidant comprising vanadium. It also provides processes for oxidation of olefins to carbonyl products, comprising contacting olefin with the aqueous catalyst solutions of the present invention. It also provides processes for oxidation of olefins to carbonyl products by dioxygen, comprising contacting olefin with the aqueous catalyst solutions of the present invention, and further comprising contacting dioxygen with the aqueous catalyst solutions. In certain aqueous catalyst solutions and related processes of the present invention, the solution has a hydrogen ion concentration greater than 0.10 mole per liter when essentially all of the oxidant is in its oxidized state. In other aqueous catalyst solution and related processes of the present invention, the solution is essentially free of sulfuric acid and sulfate ions.Type: GrantFiled: November 16, 1995Date of Patent: September 17, 1996Assignee: Catalytica, Inc.Inventors: John H. Grate, David R. Hamm, Kenneth A. Klingman, Robert J. Saxton, Shannan J. Downey
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Patent number: 5506363Abstract: The present invention provides aqueous catalyst solutions useful for oxidation of olefins to carbonyl products, comprising a palladium catalyst, a polyoxoacid or polyoxoanion oxidant comprising vanadium, and chloride ions. It also provides processes for oxidation of olefins to carbonyl products, comprising contacting olefin with the aqueous catalyst solutions of the present invention. It also provides processes for oxidation of olefins to carbonyl products by dioxygen, comprising contacting olefin with the aqueous catalyst solutions of the present invention, and further comprising contacting dioxygen with the aqueous catalyst solutions. The present invention also provides a process for the oxidation of palladium(0) to palladium(II) comprising contacting the palladium(0) with an aqueous solution comprising chloride ions and a polyoxoacid or polyoxoanion oxidant comprising vanadium.Type: GrantFiled: September 4, 1992Date of Patent: April 9, 1996Assignee: Catalytica, Inc.Inventors: John H. Grate, David R. Hamm, Robert J. Saxton, Mark T. Muraoka
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Patent number: 4709073Abstract: A process for preparing urethanes by reacting a solution of a nitrogen-containing organic compound and a hydroxyl-containing organic compound with carbon monoxide in the presence of a catalyst comprising rhodium, as a metal or compound, and essentially free of redox-active metal halide components is disclosed. In the process of this invention, the rate of conversion and selectivity to urethane is increased by providing a primary amine in the reaction solution.Type: GrantFiled: June 17, 1985Date of Patent: November 24, 1987Assignees: Catalytica Associates, Haldor TopsoeInventors: John H. Grate, David R. Hamm
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Patent number: 4705883Abstract: The invention providess a process for carbonylating a nitrogen-containing organic compound, selected from the group consisting of nitro, nitroso, azo, and azoxy compounds, by reacting said nitrogen-containing organic compound, with carbon monoxide, wherein the improvement comprises the step of:(a) reacting said nitrogen-containing compound with carbon monoxide, in the presence of a primary amine and a catalyst, essentially free of redox active metal components selected from the group consisting of rhodium and ruthenium.Type: GrantFiled: January 24, 1986Date of Patent: November 10, 1987Assignees: Catalytica Associates, Haldor TopsoeInventors: John H. Grate, David R. Hamm, Donald H. Valentine
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Patent number: 4687872Abstract: A process for preparing urethanes by reacting a solution of a nitrogen-containing organic compound and a hydroxyl-containing organic compound with carbon monoxide in the presence of a catalyst comprising rhodium, as a metal or compound, is disclosed. In the process of this invention, the rate of conversion and selectivity to urethane is increased by providing a rhodium catalyst comprising a polyamino ligand having at least two tertiary amino groups capable of coordinating with rhodium.Type: GrantFiled: December 9, 1985Date of Patent: August 18, 1987Assignees: Catalytica Associates, Haldor Topsoe A/SInventors: John H. Grate, David R. Hamm
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Patent number: 4629804Abstract: This invention relates to a process for preparing urethanes by reacting a solution of a nitrogen-containing organic compound and a hydroxyl-containing organic compound with carbon monoxide in the presence of a ruthenium catalyst. The selectivity of this process is increased by the use of methanol instead of various other alkanols, e.g. ethanol. Preferably the catalyst is a halide-free ruthenium catalyst, e.g. a ruthenium carbonyl complex.Type: GrantFiled: March 4, 1985Date of Patent: December 16, 1986Assignee: Catalytica AssociatesInventors: John H. Grate, David R. Hamm, Donald H. Valentine, Jr.
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Patent number: 4603216Abstract: This invention relates to a process for preparing urethanes by reacting a solution of a nitrogen-containing organic compound and a hydroxyl-containing organic compound with carbon monoxide in the presence of a ruthenium catalyst comprising a bis phosphine ligand.Type: GrantFiled: September 16, 1983Date of Patent: July 29, 1986Assignees: Catalytica Associates, Haldor Topsoe A/SInventors: John H. Grate, David R. Hamm, Donald H. Valentine, Jr.
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Patent number: 4600793Abstract: A process for preparing urethanes by reacting a solution of a nitrogen-containing organic compound and a hydroxyl-containing organic compound with carbon monoxide in the presence of a halide-free ruthenium catalyst is disclosed. In the process of this invention, the rate of conversion and selectivity to urethane is increased by providing a primary amine in the reaction solution.Type: GrantFiled: September 16, 1983Date of Patent: July 15, 1986Assignees: Catalytica Associates, Haldor Topsoe A/SInventors: John H. Grate, David R. Hamm, Donald H. Valentine