Patents by Inventor John H. Groffen

John H. Groffen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostics and treatments for cancers expressing tyrosine phosphorylated CRKL protein
    Patent number: 5667981
    Abstract: The invention relates to methods and kits for diagnosing cancers arising from cells which express tyrosine phosphorylated CRKL protein, such as cells having the Philadelphia (Ph) chromosome, which includes chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL), through the detection of increased levels of phosphorylated CRKL protein or through the detection of increased CRKL gene copy or mRNA expression. The invention also relates to methods of treating such cancers.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: September 16, 1997
    Assignee: Childrens Hospital of Los Angeles
    Inventors: John H. Groffen, Nora C. Heisterkamp, Johanna Ten Hoeve