Patents by Inventor John H. Kehne

John H. Kehne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Serotonin antagonists
    Publication number: 20040176413
    Abstract: The present invention is directed to a new class of serotonin 5HT2 antagonists and thier use in the treatment of a variety of diseases.
    Type: Application
    Filed: March 16, 2004
    Publication date: September 9, 2004
    Applicant: Aventis Pharmaceuticals Inc.
    Inventors: Thaddeus R. Nieduzak, Mark W. Dudley, John H. Kehne
  • Serotonin antagonists
    Publication number: 20030212141
    Abstract: The present invention is directed to a new class of serotonin 5HT2 antagonists and thier use in the treatment of a variety of diseases.
    Type: Application
    Filed: April 9, 2003
    Publication date: November 13, 2003
    Inventors: Thaddeus R. Nieduzak, Mark W. Dudley, John H. Kehne
  • Serotonin antagonists
    Publication number: 20030083325
    Abstract: The present invention is directed to a new class of serotonin 5HT2 antagonists and thier use in the treatment of a variety of diseases.
    Type: Application
    Filed: June 21, 2002
    Publication date: May 1, 2003
    Inventors: Thaddeus R. Nieduzak, Mark W. Dudley, John H. Kehne
  • Serotonin antagonists
    Publication number: 20020002174
    Abstract: The present invention is directed to a new class of serotonin 5HT2 antagonists and thier use in the treatment of a variety of diseases.
    Type: Application
    Filed: May 19, 2000
    Publication date: January 3, 2002
    Inventors: Thaddeus R. Nieduzak, John H. Kehne, Mark W. Dudley
  • Mercaptoacetylamino 1,3,4,5-tetrahydro-benzo(C)azepin-2-one disulfide derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5880119
    Abstract: The present invention relates to certain novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo?c!azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: March 9, 1999
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne
  • Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5750521
    Abstract: The present invention relates to certain mercaptoacetylamide disulfide derivatives of Formula (I) ##STR1## useful as inhibitors of enkephalinase and ACE.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: May 12, 1998
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Shujaath Mehdi, Alan M. Warshawsky, John F. French, John H. Kehne
  • Mercaptoacetylamido 1,3,4,5-tetrahydro-benzo?c!azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
    Patent number: 5731306
    Abstract: The present invention relates to certain novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo?c!azepin-3-one disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: March 24, 1998
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne
  • 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5629309
    Abstract: The present invention relates to certain novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: May 13, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne
  • Treatment of obsessive-compulsive disorders with 5-HT.sub.2 antagonists
    Patent number: 5618824
    Abstract: The present invention is directed to 5-HT.sub.2 antagonists and their use as agents in the treatment of obsessive-compulsive disorders (OCD). The invention is particularly directed to the compound (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol which is a member of a class of 5-HT.sub.2 antagonists known as N-aralkyl piperidinemethanol derivatives which are potent and selective inhibitors of the binding of serotonin at the 5-HT.sub.2 receptor site.
    Type: Grant
    Filed: March 9, 1994
    Date of Patent: April 8, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Christopher J. Schmidt, John H. Kehne, Robert A. Padich
  • Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
    Patent number: 5604221
    Abstract: The present invention relates to certain novel indane-2-mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase.
    Type: Grant
    Filed: December 12, 1995
    Date of Patent: February 18, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John H. Kehne
  • 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5567814
    Abstract: The present invention relates to certain novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: March 2, 1995
    Date of Patent: October 22, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne
  • 3-aryl-5-alkylthio-4H-1,2,4-traizoles for treatment of hyperreflexia due to spinal trauma
    Patent number: 5158968
    Abstract: This invention relates to the use of 3-aryl-5-alkylthio-4H-1,2,4-triazoles and the corresponding alkylsulfinyl- and alkylsulfonyl-4H-1,2,4-triazoles in the treatment of patients suffering from chronic hyperreflexia due to spinal trauma.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: October 27, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John H. Kehne, John M. Kane, Francis P. Miller