Patents by Inventor John H. Lawrence
John H. Lawrence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11977091Abstract: An analyzer having an inner chassis surrounded by a housing includes sample and dilution probes, a mixing housing including first and second mixing chambers, a flow cytometer including a flow cell, and sample and sheath pumps configured to perform first and second pluralities of tasks, respectively. The first plurality of tasks includes: aspirating sample into the sample probe, dispensing sample from the sample probe into the first and second mixing chambers, delivering first sample-dilution fluid mixture to the flow cell, and delivering second sample-dilution fluid mixture to the flow cell. The second plurality of tasks includes: dispensing sheath to the flow cell in cooperation with the delivery of the first sample-dilution fluid mixture to the flow cell, and dispensing sheath to the flow cell in cooperation with the delivery of the second sample-dilution fluid mixture to the flow cell.Type: GrantFiled: July 9, 2021Date of Patent: May 7, 2024Assignee: IDEXX LABORATORIES INC.Inventors: Jonathan W. Lawrence, Mark R. Dumont, Jason J. Aguiar, John H. McGibbon, Nicholas P. Prince
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Patent number: 7256182Abstract: The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers. Global delivery of nucleic acid to an intact heart has been achieved with as little as 2 minutes of intracoronary exposure to the administered nucleic acid.Type: GrantFiled: December 9, 2004Date of Patent: August 14, 2007Assignee: Johns Hopkins UniversityInventors: John H. Lawrence, III, J. Kevin Donahue
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Patent number: 6992070Abstract: The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers.Type: GrantFiled: October 15, 2001Date of Patent: January 31, 2006Assignee: The Johns Hopkins UniversityInventors: J. Kevin Donahue, Eduardo Marban, Koichi Nagata, John H. Lawrence
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Patent number: 6855701Abstract: The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers. Global delivery of nucleic acid to an intact heart has been achieved with as little as 2 minutes of intracoronary exposure to the administered nucleic acid.Type: GrantFiled: March 5, 2002Date of Patent: February 15, 2005Assignee: The Johns Hopkins UniversityInventors: John H. Lawrence, III, J. Kevin Donahue
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Patent number: 6607834Abstract: Polyester-containing multilayer biaxially-oriented polypropylene films are provided. According to the invention, a two- or three-layer polyester-containing cap layer is bonded to a monoaxially oriented polypropylene core, followed by orientation of the resulting composite in a direction transverse to the direction of orientation of the core layer. At least one tie layer is interposed between the core and the polyester. Advantageously, the polyester contains silicone fluid as a processing aid.Type: GrantFiled: March 7, 2001Date of Patent: August 19, 2003Assignee: Applied Extrusion Technologies, Inc.Inventors: Alan M. Davis, John H. Lawrence, Tung-Yao Weng
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Publication number: 20020103156Abstract: The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers. Global delivery of nucleic acid to an intact heart has been achieved with as little as 2 minutes of intracoronary exposure to the administered nucleic acid.Type: ApplicationFiled: March 5, 2002Publication date: August 1, 2002Applicant: Johns Hopkins University of Baltimore, MarylandInventors: John H. Lawrence, J. Kevin Donahue
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Publication number: 20020094326Abstract: The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers.Type: ApplicationFiled: October 15, 2001Publication date: July 18, 2002Applicant: Johns Hopkins UniversityInventors: J Kevin Donahue, Eduardo Marban, Koichi Nagata, John H. Lawrence
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Patent number: 6376471Abstract: The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers. Global delivery of nucleic acid to an intact heart has been achieved with as little as 2 minutes of intracoronary exposure to the administered nucleic acid.Type: GrantFiled: October 8, 1998Date of Patent: April 23, 2002Assignee: Johns Hopkins UniversityInventors: John H. Lawrence, III, J. Kevin Donahue
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Publication number: 20020009605Abstract: Polyester-containing multilayer biaxially-oriented polypropylene films are provided. According to the invention, a two- or three-layer polyester-containing cap layer is bonded to a monoaxially oriented polypropylene core, followed by orientation of the resulting composite in a direction transverse to the direction of orientation of the core layer. At least one tie layer is interposed between the core and the polyester. Advantageously, the polyester contains silicone fluid as a processing aid.Type: ApplicationFiled: March 7, 2001Publication date: January 24, 2002Applicant: QPF, L.L.C.Inventors: Alan M. Davis, John H. Lawrence, Tung-Yao Weng
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Patent number: 6221191Abstract: Polyester-containing multilayer biaxially-oriented polypropylene films are provided. According to the invention, a two- or three-layer polyester-containing cap layer is bonded to a monoaxially oriented polypropylene core, followed by orientation of the resulting composite in a direction transverse to the direction of orientation of the core layer. At least one tie layer is interposed between the core and the polyester. Advantageously, the polyester contains silicone fluid as a processing aid.Type: GrantFiled: February 7, 1997Date of Patent: April 24, 2001Assignee: QPF, L.L.C.Inventors: Alan M. Davis, John H. Lawrence, Tung-Yao Weng