Abstract: The present disclosure provides alfalfa plants exhibiting broad spectrum resistance to Race 1, Race 2, and Race 5 anthracnose. Such plants may comprise novel introgressed genomic regions associated with disease resistance from Race 1, Race 2, and Race 5 anthracnose. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided. Also provided are alfalfa varieties designated as C0416C4164 and H0415C4114. Provided by the invention are the seeds, plants and derivatives of alfalfa varieties C0416C4164 and H0415C4114. Also provided by the invention are tissue cultures of alfalfa varieties C0416C4164 and H0415C4114, and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing alfalfa variety C0416C4164 or H0415C4114 with itself or another alfalfa variety and plants produced by such methods.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: The present invention relates to a method of improving a mass spectrometer, a module for improving a mass spectrometer and an improved mass spectrometer. The aforementioned method uses machine learning and can greatly reduce the number and timeframe for the elimination of false positives to a couple of hours. Such method can be integrated into a mass spectrometer by inserting a computer module programmed with such method into a mass spectrometer's computer system.

Abstract: A system for centralized captioned telephone service (“C-CTS”), which includes a C-CTS system (“C-CTSS”) for providing a transcription service to a user subscribed to the C-CTS during a phone call with a peer; a mobile communications device of the user which includes a first phone number assigned from a carrier of the user; a communications device of the peer which includes a second phone number; and a plurality of caption providers that communicate with the C-CTSS. The first phone number is associated with the C-CTSS and each of the caption providers provides a captioned telephone service. A carrier of the first phone number includes a voice network, a data network, and a database that stores the first phone number of the user which is subscribed to the C-CTS. The C-CTSS includes a database that stores the first phone number of the user.

Abstract: A captioned telephone service system having the text-to-speech and answer assistance functions includes a captioner, a text-to-speech system, and an answer assistance system. The captioner provides captions to a user during a phone call between the user and a peer by receiving the peer's voice from a peer device, transcribing the peer's voice into caption data, and transferring the caption data to the user device. The text-to-speech system is configured to receive text data from the user device, convert the text data into speech, and transfer the voice of the speech to the peer device via the voice path in real time. The answer assistance system is configured to receive the caption data from the captioner, analyze the caption data to identify a question, analyze the question to generate answer suggestions, and forward the answer suggestions to the user device for review, editing, and selection.

Abstract: HIV treatment, and especially treatment of latent infected CD4 cells, can be significantly improved using a kick-and-kill approach that employs an immune stimulation component and/or HDAC inhibition as one treatment component, and that may also include a second component in which a vaccine composition, various NK cells, CAR-T cells, and/or broadly neutralizing antibodies are administered.

Abstract: HIV treatment, and especially treatment of latent infected CD4 cells, can be significantly improved using a kick-and-kill approach that employs an immune stimulation component and/or HDAC inhibition as one treatment component, and that may also include a second component in which a vaccine composition, various NK cells, CAR-T cells, and/or broadly neutralizing antibodies are administered.

Abstract: A captioned telephone service system having the text-to-speech and answer assistance functions includes a captioner, a text-to-speech system, and an answer assistance system. The captioner provides captions to a user during a phone call between the user and a peer by receiving the peer’s voice from a peer device, transcribing the peer’s voice into caption data, and transferring the caption data to the user device. The text-to-speech system is configured to receive text data from the user device, convert the text data into speech, and transfer the voice of the speech to the peer device via the voice path in real time. The answer assistance system is configured to receive the caption data from the captioner, analyze the caption data to identify a question, analyze the question to generate answer suggestions, and forward the answer suggestions to the user device for review, editing, and selection.

Abstract: A system for identifying spoken language in a telecommunications relay service, which includes a call serving entity; and a plurality of automatic speech recognition groups where each of the automatic speech recognition groups includes an associated automatic speech recognition engine that recognizes and transcribes speech to a predefined language. One of the plurality of automatic speech recognition groups is set as a default automatic speech recognition group and automatic speech recognition engines transcribe and convert peer voices into text packets. The text packets are scored by the automatic speech recognition engine and transmitted to the call serving entity to determine whether the text packets meet a predetermined threshold based on their respective scores with the text packet having the highest score that meets or exceeds the predetermine threshold transmitted to a user.

Abstract: The present disclosure provides methods for treating or preventing Huntington's disease (HD) in a subject in need thereof, comprising administering a therapeutic agent that activates mTORC 1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment, and methods for modulating mHTT-associated metabolic phenotypes and/or reversal of striatal atrophy by administering a therapeutic agent that activates mTORC1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment.

Abstract: A method performed by a data storage apparatus of maintaining filesystem object attributes in connection with a plurality of drivers is provided. Each driver of the plurality is configured to operate on a respective set of filesystem objects. The method includes (a) for each driver of the plurality, creating a respective driver-specific storage volume; (b) storing, within each driver-specific storage volume, attributes specific to respective filesystem objects operated on by the driver of that driver-specific storage volume; and (c) while operating a particular driver of the plurality on a particular filesystem object, using values of the stored attributes specific to that particular filesystem object operated on by that particular driver. An apparatus, system, and computer program product for performing a similar method are also provided.

Abstract: A system for centralized captioned telephone service (“C-CTS”), which includes a C-CTS system (“C-CTSS”) for providing a transcription service to a user subscribed to the C-CTS during a phone call with a peer; a mobile communications device of the user which includes a first phone number assigned from a carrier of the user; a communications device of the peer which includes a second phone number; and a plurality of caption providers that communicate with the C-CTSS. The first phone number is associated with the C-CTSS and each of the caption providers provides a captioned telephone service. A carrier of the first phone number includes a voice network, a data network, and a database that stores the first phone number of the user which is subscribed to the C-CTS. The C-CTSS includes a database that stores the first phone number of the user.

Abstract: A system for identifying spoken language in a telecommunications relay service, which includes a call serving entity; and a plurality of automatic speech recognition groups where each of the automatic speech recognition groups includes an associated automatic speech recognition engine that recognizes and transcribes speech to a predefined language. One of the plurality of automatic speech recognition groups is set as a default automatic speech recognition group and automatic speech recognition engines transcribe and convert peer voices into text packets. The text packets are scored by the automatic speech recognition engine and transmitted to the call serving entity to determine whether the text packets meet a predetermined threshold based on their respective scores with the text packet having the highest score that meets or exceeds the predetermine threshold transmitted to a user.

Abstract: HIV treatment, and especially treatment of latent infected CD4 cells, can be significantly improved using a kick-and-kill approach that employs an immune stimulation component and/or HDAC inhibition as one treatment component, and that may also include a second component in which a vaccine composition, various NK cells, CAR-T cells, and/or broadly neutralizing antibodies are administered.

Abstract: Provided are genetically modified NK cells expressing a chimeric antigen receptor targeting an EGFR superfamily receptor. The CAR can comprise an intracellular domain of Fc?RI? and further recombinant proteins expressed by the genetically modified NK cells are CD16, autocrine growth stimulating cytokines, and optionally one of IL-12, a TGF-beta trap, or a homing receptor. Also described are methods for treating a patient having or suspected of having a disease that is treatable with NK-92 cells, such as cancer, comprising administering to the patient the genetically modified NK cells.

Abstract: Provided are genetically modified NK cells expressing a chimeric antigen receptor targeting an EGFR superfamily receptor. The CAR can comprise an intracellular domain of Fc?RI? and further recombinant proteins expressed by the genetically modified NK cells are CD16, autocrine growth stimulating cytokines, and optionally one of IL-12, a TGF-beta trap, or a homing receptor. Also described are methods for treating a patient having or suspected of having a disease that is treatable with NK-92 cells, such as cancer, comprising administering to the patient the genetically modified NK cells.

Abstract: HIV treatment, and especially treatment of latent infected CD4 cells, can be significantly improved using a kick-and-kill approach that employs an immune stimulation component and/or HDAC inhibition as one treatment component, and that may also include a second component in which a vaccine composition, various NK cells, CAR-T cells, and/or broadly neutralizing antibodies are administered.

Abstract: An ACE2-Fc hybrid construct is used as a therapeutic and/or analytic entity to treat an individual infected with a coronavirus or to detect a coronavirus in an analyte. In selected embodiments, the Fc portion of the hybrid construct is an IgA Fc portion, and in still further embodiments the ACE2 portion has a mutation that reduces or abolishes ACE2 catalytic activity.

Abstract: Provided are genetically modified NK cells expressing a chimeric antigen receptor targeting an EGFR superfamily receptor. The CAR can comprise an intracellular domain of Fc?RI? and further recombinant proteins expressed by the genetically modified NK cells are CD16, autocrine growth stimulating cytokines, and optionally one of IL-12, a TGF-beta trap, or a homing receptor. Also described are methods for treating a patient having or suspected of having a disease that is treatable with NK-92 cells, such as cancer, comprising administering to the patient the genetically modified NK cells.

Abstract: Compositions and methods are provided for generating a clonal population of transfected eukaryotic cells derived from a single cell. The method includes transfecting a population of eukaryotic cells with a multi-cistronic nucleic acid vector followed by non-antibiotic selection and characterization of the selected cells. The multi-cistronic nucleic acid vector encodes a selection element which may be an autocrine protein, miRNA, and/or shRNA.