Abstract: A nutritional supplement contains 50% to 80% by weight of trimethylglycine; 5% to 30% by weight of L-?-glycerophosphorylcholine; 5% to 15% by weight of caffeine; and 5% to 10% by weight of an ingredient selected from the group consisting of an L-amino acid, creatyl-L-leucine, Corynanthe yohimbe bark extract, theacrine, and mixtures thereof. The nutritional supplement is useful for enhancing energy, mental acuity, cognitive performance, and reaction time in a subject in need thereof.

Abstract: A formulation for providing hydration and nutritional components to a subject includes from about 1,000 mg/serving to about 7,000 mg/serving of trimethylglycine, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable precursor thereof; from about 1 mg/serving to about 4,000 mg/serving of beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof; an electrolyte salt; optionally a purine nucleotide; and optionally a carbohydrate. The formulation may be an orally administered liquid including an aqueous carrier in an amount sufficient to provide a total volume/serving of about 2 oz. to about 32 oz.

Abstract: A blow-molded bottle for a carbonated beverage includes a threaded mouth, a cylindrical side wall, a bottom, and a standard fill capacity of 37.5 mL to 105 mL. The bottle is blow-molded from a laminated preform including an outer layer formed from polyethylene terephthalate, an intermediate gas barrier layer formed from a polyamide comprising a dicarboxylic acid component and a diamine component comprising m-xylylenediamine, and an inner layer comprising polyethylene terephthalate. The laminated preform may weigh from about 4 to 16 grams. The polyamide layer provides the bottle with excellent resistance to carbon dioxide, hydrogen, and nitrogen transmission and prevents the degradation of nutrients and flavors.

Abstract: This invention discloses a nutritional composition of matter that effectively provide a nootropic effect beyond the effects simple obtain by cannabinoids alone. Effectively reduce anxiety due to ingestion of xanthines containing oral products. Similarly reduce the side effects associated with the exogenous ingestion of yohimbine and its derivatives.

Abstract: A hard seltzer is made by dissolving a sodium ion source in an aqueous ethanol solution, wherein the aqueous ethanol solution comprises from 1% to 14% by volume of ethanol; dissolving a potassium ion source in the aqueous ethanol solution; dissolving a magnesium ion source in the aqueous ethanol solution; and carbonating the aqueous ethanol solution to produce the hard seltzer. The sodium ion source, the potassium ion source, and the magnesium ion source are used in amounts effective to provide a hard seltzer comprising 20 to 400 mg/serving of sodium ions, 20 to 400 mg/serving of potassium ions; and 3 to 400 mg/serving of magnesium ions.

Abstract: Various embodiments relate to bioactive compositions, including a first component including 1 to 300 mg/dose of a psychotropic cannabinoid, a non-psychotropic cannabinoid, or a mixture thereof; a second component including 1 to 400 mg/dose of a methylxanthine; and an aqueous carrier.

Abstract: This invention discloses a medicinal composition of matter that effectively provide a nootropic effect beyond the effects simple obtain by cannabinoids alone. And, effectively reduce anxiety due to ingestion of xanthines containing oral products.

Abstract: A nutritional supplement contains 50% to 80% by weight of trimethylglycine; 5% to 30% by weight of L-?-glycerophosphorylcholine; 5% to 15% by weight of caffeine; and 5% to 10% by weight of an ingredient selected from the group consisting of an L-amino acid, creatyl-L-leucine, Corynanthe yohimbe bark extract, theacrine, and mixtures thereof. The nutritional supplement is useful for enhancing energy, mental acuity, cognitive performance, and reaction time in a subject in need thereof.

Abstract: This invention discloses a medicinal composition of matter that effectively provide a nootropic effect beyond the effects simple obtain by cannabinoids alone. And, effectively reduce anxiety due to ingestion of xanthines containing oral products.

Abstract: This invention discloses a nutritional composition of matter that effectively provide a nootropic effect beyond the effects simple obtain by cannabinoids alone. Effectively reduce anxiety due to ingestion of xanthines containing oral products. Similarly reduce the side effects associated with the exogenous ingestion of yohimbine and its derivatives.

Abstract: This invention discloses a nutritional composition of matter that effectively reduces and stabilize glucose levels in the blood of mammals by deliberately inducing ketosis. The compositions comprise, Sodium Beta-Hydroxybutyrate, Potassium Beta-Hydroxybutyrate, Magnesium Beta-Hydroxybutyrate, Calcium Beta-Hydroxybutyrate, Ketone Esters, Medium Chain Triglycerides (MCT) with at least one or more from L-Leucine, L-Lysine, L-isoleucine, Caffeine, Yohimbine, Yohimbe, Berberine and Creatine or its derivatives (such as creatine salt, and Creatyl-L-leucine).

Abstract: Creatine derivatives and compositions containing a bioactive form of creatine. The new chemical entity comprises an acetyl creatine, N-acyl creatines, N,N-diacyl creatines or any N-acetyl creatine species with enhanced solubility and bioavailability. Also provided by this invention are various methods for providing several beneficial effects that comprise administering compositions comprising N-acetyl creatine, N-acyl creatines, N,N-diacyl creatines or any N-acetyl creatine species to a mammalian subject, either chronically or acutely.

Abstract: Creatine derivatives and compositions containing a [one or more?] bioactive form[s] of creatine. The new chemical entity comprises an acetyl creatine, N-acyl creatines, N,N-diacyl creatines or any N-acetyl creatine species with enhanced solubility and bioavailability. Also provided by this invention are various methods for providing several beneficial effects that comprise administering compositions comprising N-acetyl creatine, N-acyl creatines, N,N-diacyl creatines or any N-acetyl creatine species to a mammalian subject, either chronically or acutely.

Abstract: Compositions containing one or more bioactive forms of creatine, which are aqueous compositions in which the one or more bioactive forms of creatine do not appreciably degrade into creatinine. Also are methods for providing various beneficial effects which comprise administering aqueous compositions comprising at least one creatinol O-phosphate species to a mammalian subject, either chronically or acutely.

Abstract: A composition of dipeptides or tripeptides or ester derivatives may be used as a nutritional supplement and to modulate expression of genes associated with healthy maintenance and regulation of muscular and neurological tissue. The compositions include dipeptides and/or tripeptides of branched chain amino acids and optionally include adjuvants, anti-aging compounds and may be provided in a dissolvable powder or liquid form.

Abstract: The present invention provides pharmaceutical and dietary compositions in which pyrroloquinoline quinone (PQQ) and its derivatives are combined with other biologically active compounds to produce a synergistic beneficial effect beyond the effect produced by PQQ or its derivatives alone. The present invention also provides methods for providing various beneficial effects which comprise administering these compositions to a mammalian subject.

Abstract: An internal chamber incorporated with the cap of a container, for example, a disposable beverage bottle. The internal chamber has an internal bore designed to hold a powder or liquid that can be released into the container. The chamber is inserted into a bottle or similar container when the cap is placed over the opening. A push-button on the top of the cap advances an actuator within the internal bore to push a diaphragm out of the distal end outlet port in the chamber to release the ingredient(s) within the internal chamber into the container. The diaphragm also has two or more peripheral guide rails to ensure that it remains aligned with the chamber housing during those movements. Alternative embodiments utilize a dome cover over the push-button. In use, the cap of the container can be removed, which will simultaneously remove the chamber, allowing the liquid in the container to be consumed or decanted.

Abstract: Compositions containing one or more bioactive forms of creatine, which are aqueous compositions in which the one or more bioactive forms of creatine do not appreciably degrade into creatinine. Also are methods for providing various beneficial effects which comprise administering aqueous compositions comprising at least one creatinol O-phosphate species to a mammalian subject, either chronically or acutely.

Abstract: The present invention provides amide-protected creatine molecules and compositions, containing one or more bioactive forms of creatine in aqueous compositions, wherein bioactive forms of creatine do not appreciably degrade into creatinine. Also provided are various beneficial effects of administering aqueous compositions having at least one amide-protected creatine molecule.

Abstract: An internal chamber incorporated with the cap of a container, for example, a disposable beverage bottle. The internal chamber has an internal bore designed to hold a powder or liquid that can be released into the container. The chamber is inserted into a bottle or similar container when the cap is placed over the opening. A push-button on the top of the cap advances an actuator within the internal bore to push a diaphragm out of the distal end outlet port in the chamber to release the ingredient(s) within the internal chamber into the container. The diaphragm also has two or more peripheral guide rails to ensure that it remains aligned with the chamber housing during those movements. Alternative embodiments utilize a dome cover over the push-button. In use, the cap of the container can be removed, which will simultaneously remove the chamber, allowing the liquid in the container to be consumed or decanted.