Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: Thermal imaging odometry and navigation systems and related techniques are provided to improve the operational flexibility of autonomous/unmanned vehicles. A thermal imaging odometry system includes a thermal imaging module configured to be coupled to an unmanned vehicle, a ranging sensor system fixed to the thermal imaging module, and a logic device. The thermal imaging module provides thermal imagery of a scene in view of the unmanned vehicle and centered about an optical axis of the thermal imaging module, where the optical axis is fixed relative to an orientation of the unmanned vehicle. The ranging sensor system provides ranging sensor data indicating a standoff distance between the thermal imaging module and a surface intersecting the optical axis of the thermal imaging module. The logic device receives thermal images of the scene and corresponding ranging sensor data and determines an estimated relative velocity of the unmanned vehicle.

Abstract: A reinforced polymer composite that includes a Class A surface and method of making are disclosed. A reinforced polymer composite comprises a polymeric barrier layer that comprises a barrier layer first surface, a barrier layer second surface, and a plurality of hard segment domains. A reinforced polymer composite also comprises a reinforced polymeric layer covering at least a portion of the barrier layer first surface, wherein the barrier layer second surface exhibits a Class A quality, and wherein the plurality of hard segment domains substantially suppress deformation of the polymeric barrier layer at a molding temperature of the reinforced polymer composite. Optionally, an in-mold coating that has a Class A surface covers at least a portion of the barrier layer second surface.

Abstract: The present invention teaches a closed loop energy system including means capable of managing both cooling cycle and the fuel/oxidant gas flow in conjunction with a fuel cell. The system includes a plurality of galvanic cells, gas flow conduit means, internal fluid flow conduit means, heat exchanger means, liquid-gas separator means, and gas repressurization means.

Abstract: The present invention teaches a closed loop energy system including means capable of managing both the cooling cycle and the fuel/oxidant gas flow in conjunction with a fuel cell. The system includes a plurality of galvanic cells, gas flow conduit means, internal fluid flow conduit means, heat exchanger means, liquid-gas separator means, and gas repressurization means.

Abstract: The present invention teaches a closed loop energy system including means capable of managing both the cooling cycle and the fuel/oxidant gas flow in conjunction with a fuel cell. The system includes a plurality of galvanic cells, gas flow conduit means, internal fluid flow conduit means, heat exchanger means, liquid-gas separator means, and gas repressurization means.

Abstract: An integrated power system is located adjacent a body of saline water. The power system includes a solar powered and a wind driven engine. Desalinization and electrolysis of the water is provided. The system produces carbon dioxide and hydrogen which are used to generate methanol. The methanol can be used as a fuel to drive a combustion engine.

Abstract: An integrated power system is located adjacent a body of saline water. The power system includes a solar powered and a wind driven engine. Desalinization and electrolysis of the water is provided. The system produces carbon dioxide and hydrogen which are used to generate methanol. The methanol can be used as a fuel to drive a combustion engine.

Abstract: A gas sampling device whose operation is activated by the blast whose gas to be sampled. This blast activates a switch which in turn starts the operation of a control box which thereafter sequentially outputs pneumatic signals at preset time intervals. These signals are received by a sampling unit assembly which functions in response thereto to receive and retain a gas sample from the blast.

Abstract: X-ray detectable fiducial markers are associated with a stereotactic surgery frame. The frame is fixed with respect to a patient's anatomy and defines a predetermined three-dimensional coordinate system in which surgical devices may be precisely positioned. A desired target area of the anatomy is detected in a cross-sectional CT scanner depiction of the combined stereotactic frame and patient anatomy. The target's coordinates with respect to the frame are calculated based on three non-collinear fiducial points also located within the cross-section and having known coordinates both with respect to the frame and with respect to the target.In the exemplary embodiment, detachable fiducial point-defining members are associated with a stereotactic surgical frame. For example, each member may be a plate having a series of parallel grooves or slots which progressively increase in length from one slot to the next. The frame coordinates of the end points of each slot are predetermined and known.

Abstract: A system and method for visually recording an ECG signal in a helical track about a cylindrical record. The "R" wave of each heart beat is detected and utilized to synchronize the first recorded heart beat pulse of each line. Imaging on the record is by optical exposure of a photographic recording medium.

Abstract: An ambulatory electrocardiographic tape recording (DCG) taken over an extended period of time, such as 24 hours, is analyzed with substantial accuracy by randomly selecting a sample of time periods of a specific duration (such as a 2% sample) and printing out a hard copy record of the electrocardiogram at these times for visual analysis. The simplicity of this method and the system performing it combined with high accuracy in quantifying cardiac arrhythmias makes it perferable for most clinical purposes to conventional methods of analyzing DCG's.

Abstract: A source of gas under pressure is interconnected by conduit means with at least one point of use through gas conditioning means which may include filter means and heater means and retention means specially arranged to maintain the temperature of a stream of gas for a desired period of time and a source of sterilizing fluid is interconnected with the conduit means and is arranged to scavenge the conduit means, the point of use and the gas conditioning means in coordination with the opening of vent means associated with the point of use, the gas conditioning means and the conduit means.