Patents by Inventor John H. Rossmeisl
John H. Rossmeisl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11952568Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: GrantFiled: April 5, 2019Date of Patent: April 9, 2024Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
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Publication number: 20240008911Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.Type: ApplicationFiled: July 7, 2023Publication date: January 11, 2024Inventors: Rafael V. Davalos, John H. Rossmeisl, Paulo A. Garcia
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Patent number: 11737810Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.Type: GrantFiled: October 13, 2020Date of Patent: August 29, 2023Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Rafael V. Davalos, John H. Rossmeisl, Paulo A. Garcia
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Publication number: 20230212551Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: ApplicationFiled: March 10, 2023Publication date: July 6, 2023Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
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Patent number: 11655466Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: GrantFiled: July 24, 2015Date of Patent: May 23, 2023Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
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Patent number: 11607537Abstract: This disclosure describes the methods, devices, and systems of treating diseased tissue with integrated nanosecond pulse irreversible electroporation. Methods and systems as disclosed provide MRI compatible shielded electrodes and electrode leads to prevent emanating radiofrequency noise and improve image quality, disconnecting the electrode from the cable linkage to the pulse generator reduce electromagnetic interference and image artifacts, placing electrodes strategically within a guide cannula to minimize distortion from heterogeneities or maximize ablation within the tissue, utilizing conductive fluids, innate or external, such as cerebral spinal fluid or grounding pads to provide a pathway for current return, and for timing of the electrical waveforms with inherent brain electrical activity.Type: GrantFiled: December 5, 2018Date of Patent: March 21, 2023Assignees: Virginia Tech Intellectual Properties, Inc., VoltMed, Inc.Inventors: Eduardo Latouche, Samuel Lesko, Lucy Epshteyn, Christopher B. Arena, John H. Rossmeisl, Jr., Melvin Lorenzo, Rafael Davalos
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Patent number: 11453873Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: GrantFiled: August 8, 2019Date of Patent: September 27, 2022Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Rafael V. Davalos, Paulo A. Garcia, John H. Rossmeisl, John L. Robertson, Robert E. Neal, II
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Patent number: 11254926Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: GrantFiled: May 6, 2019Date of Patent: February 22, 2022Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
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Publication number: 20210186600Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.Type: ApplicationFiled: February 10, 2021Publication date: June 24, 2021Inventors: Rafael V. Davalos, Paulo A. Garcia, John L. Robertson, John H. Rossmeisl, Robert E. Neal, II
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Patent number: 10959772Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.Type: GrantFiled: February 14, 2019Date of Patent: March 30, 2021Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Rafael V. Davalos, Paulo A. Garcia, John L. Robertson, John H. Rossmeisl, Robert E. Neal, II
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Publication number: 20210022795Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.Type: ApplicationFiled: October 13, 2020Publication date: January 28, 2021Inventors: Rafael V. Davalos, John H. Rossmeisl, Paulo A. Garcia
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Patent number: 10828085Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.Type: GrantFiled: November 1, 2018Date of Patent: November 10, 2020Inventors: Rafael V. Davalos, John H. Rossmeisl, Paulo A. Garcia
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Patent number: 10828086Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.Type: GrantFiled: December 26, 2018Date of Patent: November 10, 2020Inventors: Rafael V. Davalos, John H. Rossmeisl, Paulo A. Garcia
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Publication number: 20200093541Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: ApplicationFiled: July 24, 2015Publication date: March 26, 2020Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
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Publication number: 20190376055Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: ApplicationFiled: August 8, 2019Publication date: December 12, 2019Inventors: Rafael V. Davalos, Paulo A. Garcia, John H. Rossmeisl, John L. Robertson, Robert E. Neal, II
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Publication number: 20190256839Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: ApplicationFiled: May 6, 2019Publication date: August 22, 2019Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
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Publication number: 20190233809Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: ApplicationFiled: April 5, 2019Publication date: August 1, 2019Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
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Publication number: 20190175260Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.Type: ApplicationFiled: February 14, 2019Publication date: June 13, 2019Inventors: Rafael V. Davalos, Paulo A. Garcia, John L. Robertson, John H. Rossmeisl, Robert E. Neal, II
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Publication number: 20190133671Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.Type: ApplicationFiled: December 26, 2018Publication date: May 9, 2019Inventors: Rafael V. Davalos, John H. Rossmeisl, Paulo A. Garcia
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Patent number: 10272178Abstract: The present invention provides engineered tissue scaffolds, engineered tissues, and methods of using them. The scaffolds and tissues are derived from natural tissues and are created using non-thermal irreversible electroporation (IRE). Use of IRE allows for ablation of cells of the tissue to be treated, but allows vascular and neural structures to remain essentially unharmed. Use of IRE thus permits preparation of thick tissue scaffolds and tissues due to the presence of vasculature within the scaffolds. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.Type: GrantFiled: February 3, 2017Date of Patent: April 30, 2019Inventors: Rafael V. Davalos, Paulo A. Garcia, John H. Rossmeisl