Abstract: Methods of preparing compounds of Formula I are provided.

Abstract: Methods of preparing compounds of Formula I are provided.

Abstract: Methods of preparing compounds of Formula I 1

Abstract: Methods of preparing compounds of Formula I are provided.

Abstract: Methods of preparing compounds of Formula I 1

Abstract: A novel process for producing a 1-H-tetrazole-5-thiol of the formula: ##STR1## in which R.sup.1 is hydrogen; lower alkyl; lower alkyl substituted with a carboxylic acid, a carboxylic acid lower alkyl ester, or an hydroxy group; phenyl or phenyl substituted with a halogen, a lower alkyl group, or a lower alkoxy group; benzyl or benzyl substituted with a halogen, a lower alkyl group, or 1-3 alkoxy groups of 1-3 carbon atoms; or trichloroethyl,which process comprises:(a) reacting a sulfinyl or sulfonyl cyanide of the formula:RS(O).sub.n CNin whichn is 1 or 2 andR is alkyl; phenyl or phenyl substituted with a halogen, a lower alkyl group, or a lower alkoxy group; benzyl or benzyl substituted on the phenyl ring with a halogen, a lower alkyl group, or a lower alkoxy group; or an alicyclic group,with an azide of the formula R.sup.1 N.sub.5, in which R.sup.1 is as defined above, to form a 5-sulfinyl or sulfonyl-1-H-tetrazole of the formula: ##STR2## in which n is 1 or 2, andR and R.sup.

Abstract: A novel process for producing a 1-H-tetrazole-5-thiol of the formula ##STR1## in which R.sup.1 is hydrogen; lower alkyl; lower alkyl substituted with a carboxylic acid, a carboxylic acid lower alkyl ester, or an hydroxy group; phenyl or phenyl substituted with a halogen, a lower alkyl group, or a lower alkoxy group; benzyl or benzyl substituted with a halogen, a lower alkyl group, or 1-3 alkoxy groups of 1-3 carbon atoms; or trichloroethyl,which process comprises:(a) reacting a sulfinyl or sulfonyl cyanide of the formula:RS(O).sub.n CNin whichn is 1 or 2 andR is alkyl; phenyl or phenyl substituted with a halogen, a lower alkyl group, or a lower alkoxy group; benzyl or benzyl substituted on the phenyl ring with a halogen, a lower alkyl group, or a lower alkoxy group; or an alicyclic group, with an azide of the formula R.sup.1 N.sub.3, in which R.sup.1 is as defined above, to form a 5-sulfinyl or sulfonyl-1-H-tetrazole of the formula: ##STR2## in which n is 1 or 2, andR and R.sup.

Abstract: N-Protected-tetrazole-5-carboxylic acid derivatives of the formula: ##STR1## in which R is --OM, halo or lower alkoxy wherein M is hydrogen, an alkali metal or an alkaline earth metal; andR.sub.1 is phenyl, 4-methoxyphenyl, 2,4-dimethoxyphenyl or 2,4,6-trimethoxyphenyl,are produced by addition of R.sub.1 --CH.sub.2 --N.sub.3 to a lower alkyl cyanoformate followed by saponification, optional acidification, and conversion to the carbonyl halide. The N-protected tetrazole-5-carbonylhalides are intermediates for the production of anti-allergic agents.

Abstract: Variously substituted oxanilic acid esters possessing anti-secretory activity are useful anti-ulcer agents.

Abstract: Anti-allergic agents of aromatic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of .alpha.-naphthyl, .beta.-napthtyl, phenyl, 2,6-di-chlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy (lower)alkoxy, 2-(oxalyloxy) ethoxy, benzyloxy, N-mono- and di-lower alkylamino(lower)alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono and di lower alkylamino, carboxy, lower alkylcarbonyl, carb(lower)alkoxy, phenoxy(lower)alkoxy, and oxalamidophenoxy radicals;and pharmaceutically acceptable salts thereof.

Abstract: Anti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, .alpha.-naphthyl, .beta.

Abstract: Anti-allergic agents of aromatic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of .alpha.-naphthyl, .beta.-naphthyl, phenyl, 2,6-di-chlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy (lower)alkoxy, 2-(oxalyloxy) ethoxy, benzyloxy, N-mono- and di-lower alkylamino(lower)alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono and di lower alkylamino, carboxy, lower alkylcarbonyl, carb(lower)alkoxy, phenoxy(lower)alkoxy, and oxalamidophenoxy radicals;And pharmaceutically acceptable salts thereof.

Abstract: Variously substituted oxanilic acid esters possessing anti-secretary activity are useful anti-ulcer agents.

Abstract: Anti-allergic agents of N-aromatic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R.sup.1 is --CN or --CONH.sub.2 ;R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halo, polyhalo(lower)alkyl, lower alkyl carbonyl or carb(lower)alkoxy;X is ##STR2## where R.sup.3 is lower alkyl and R.sup.4 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof.

Abstract: Anti-allergic agents of N-aromatic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R.sup.1 is --CN or --CONH.sub.2 ;R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halo, polyhalo(lower)alkyl, lower alkyl carbonyl or carb(lower)alkoxy;X is --CH.sub.2 --, --O--, or ##STR2## where R.sup.3 is lower alkyl; and R.sup.4 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof.

Abstract: Anti-allergic agents of N-(pyridyl)-1H-(or 2H) Tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R is --H or lower alkyl;R.sup.2 is --H, lower alkoxy, --CN, di(lower) alkylamino, halo or polyhalo(lower) alkyl;Or a pharmaceutically acceptable salt thereof.

Abstract: Anti-allergic agents of N-(2-thiazolyl)-1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R is hydrogen, lower alkyl, lower alkoxy, --CN, (lower)alkyl amino, di(lower) alkylamino, polyhalo(lower)alkyl, halo and carbamoyl;Or a pharmaceutically acceptable salt thereof.

Abstract: Anti-allergic agents of N-(2-pyrazinyl) 1H- (or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R.sup.1 is hydrogen, lower alkylamino, di(lower)alkylamino, cyano, halo, lower alkyl or halo; andR.sup.2 is hydrogen or cyano;Or a pharmaceutically acceptable salt thereof.

Abstract: Anti-allergic agents of N-(2-pyrimidinyl)-1H-(or 2H)tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R.sup.1 and R.sup.2 are independently hydrogen, cyano, lower alkyl, carbamyl, halo, (lower) alkylamino or di(lower)alkylamino, or a pharmaceutically acceptable salt thereof.

Abstract: Anti-allergic agents of N-(pyridyl)-oxamic acid derivation present the following formulae: ##STR1## in which R is --H or lower alkyl; R.sup.2 is --H, lower alkoxy, lower alkyl, halo or polyhalo(lower) alkyl;Or a pharmaceutically acceptable salt thereof.