Patents by Inventor John H. van Duzer

John H. van Duzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20160375021
    Abstract: The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Application
    Filed: September 12, 2016
    Publication date: December 29, 2016
    Inventors: John H. van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • METHODS OF MAKING PROTEIN DEACETYLASE INHIBITORS
    Publication number: 20160355486
    Abstract: The present invention relates to methods and intermediates useful for the synthesis of protein deacetylase inhibitors.
    Type: Application
    Filed: June 8, 2016
    Publication date: December 8, 2016
    Inventors: Farzaneh Seyedi, John H. van Duzer
  • Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
    Patent number: 9464073
    Abstract: The present invention relates to pyrimidine hydroxy amide compounds, the use of such compounds in the inhibition of HDAC6, and the use of such compounds in the treatment of various diseases, disorders, or conditions related to HDAC6.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: October 11, 2016
    Assignee: Acetylon Pharmaceuticals, Inc.
    Inventors: Ralph Mazitschek, John H. van Duzer
  • PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS
    Publication number: 20160279128
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1, HDAC2, and/or HDAC6. Also provided herein are methods for inhibiting migration of a neuroblastoma cell, inducing maturation of a neuroblastoma cell, and altering cell cycle progression of a neuroblastoma cell comprising administering to the cell a therapeutically effective amount of a HDAC1, HDAC2, and/or HDAC6 selective inhibitor or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 20, 2016
    Publication date: September 29, 2016
    Inventors: John H. van Duzer, Ralph Mazitschek, Simon Stewart Jones, Min Yang, David Lee Tamang
  • Selective HDAC1 and HDAC2 inhibitors
    Patent number: 9421212
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1 and/or HDAC2. Such diseases include cancer, sickle-cell anemia, beta-thalassemia, and HIV.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: August 23, 2016
    Assignee: ACETYLON PHARMACEUTICALS, INC.
    Inventors: John H. van Duzer, Ralph Mazitschek
  • Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
    Patent number: 9409890
    Abstract: The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: August 9, 2016
    Assignee: ACETYLON PHARAMCEUTICALS, INC.
    Inventors: John H. van Duzer, Ralph Mazitschek, Yanbing Ding, Nan Yu, Yun Cao, Yong Liu
  • PIPERIDINE DERIVATIVES AS HDAC1/2 INHIBITORS
    Publication number: 20160168093
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity.
    Type: Application
    Filed: December 11, 2015
    Publication date: June 16, 2016
    Inventors: John H. van Duzer, Ralph Mazitschek
  • SELECTIVE HDAC1 AND HDAC2 INHIBITORS
    Publication number: 20160067259
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1 and/or HDAC2. Such diseases include cancer, sickle-cell anemia, beta-thalassemia, and HIV.
    Type: Application
    Filed: August 12, 2015
    Publication date: March 10, 2016
    Applicant: Acetylon Pharmaceuticals, Inc.
    Inventors: John H. van Duzer, Ralph Mazitschek
  • Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
    Patent number: 9278963
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1, HDAC2, and/or HDAC6. Also provided herein are methods for inhibiting migration of a neuroblastoma cell, inducing maturation of a neuroblastoma cell, and altering cell cycle progression of a neuroblastoma cell comprising administering to the cell a therapeutically effective amount of a HDAC1, HDAC2, and/or HDAC6 selective inhibitor or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: March 8, 2016
    Assignee: Acetylon Pharmaceuticals, Inc.
    Inventors: John H. van Duzer, Ralph Mazitschek, Simon Stewart Jones, Min Yang, David Lee Tamang
  • SELECTIVE HDAC3 INHIBITORS
    Publication number: 20150299130
    Abstract: Provided herein are HDAC3 inhibitors, as well as methods of treatment comprising administering these compounds to a subject in need thereof.
    Type: Application
    Filed: June 29, 2015
    Publication date: October 22, 2015
    Inventors: John H. van Duzer, Ralph Mazitschek
  • Selective HDAC1 and HDAC2 inhibitors
    Patent number: 9145412
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1 and/or HDAC2. Such diseases include cancer, sickle-cell anemia, beta-thalassemia, and HIV.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: September 29, 2015
    Assignee: ACETYLON PHARMACEUTICALS, INC.
    Inventors: John H. van Duzer, Ralph Mazitschek
  • Selective HDAC3 inhibitors
    Patent number: 9139583
    Abstract: Provided herein are inhibitors of HDAC3, as well as methods of treatment comprising administering those compounds to a subject in need thereof.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: September 22, 2015
    Assignee: ACETYLON PHARMACEUTICALS, INC.
    Inventors: John H. van Duzer, Ralph Mazitschek
  • PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HDAC6 SELECTIVE INHIBITORS
    Publication number: 20150239869
    Abstract: The present invention relates to pyrimidine hydroxy amide compounds, the use of such compounds in the inhibition of HDAC6, and the use of such compounds in the treatment of various diseases, disorders, or conditions related to HDAC6.
    Type: Application
    Filed: February 26, 2015
    Publication date: August 27, 2015
    Inventors: Ralph Mazitschek, John H. van Duzer
  • Selective HDAC3 inhibitors
    Patent number: 9096549
    Abstract: Provided herein are HDAC3 inhibitors, as well as methods of treatment comprising administering these compounds to a subject in need thereof.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: August 4, 2015
    Assignee: ACETYLON PHARMACEUTICALS, INC.
    Inventors: John H. van Duzer, Ralph Mazitschek
  • REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20150045380
    Abstract: The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Application
    Filed: October 22, 2014
    Publication date: February 12, 2015
    Inventors: John H. van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • SELECTIVE HDAC3 INHIBITORS
    Publication number: 20140249148
    Abstract: Provided herein are inhibitors of HDAC3, as well as methods of treatment comprising administering those compounds to a subject in need thereof.
    Type: Application
    Filed: January 31, 2014
    Publication date: September 4, 2014
    Inventors: John H. van Duzer, Ralph Mazitschek
  • SELECTIVE HDAC3 INHIBITORS
    Publication number: 20140243345
    Abstract: Provided herein are HDAC3 inhibitors, as well as methods of treatment comprising administering these compounds to a subject in need thereof.
    Type: Application
    Filed: January 31, 2014
    Publication date: August 28, 2014
    Inventors: John H. van Duzer, Ralph Mazitschek
  • REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20140142117
    Abstract: The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Application
    Filed: November 11, 2013
    Publication date: May 22, 2014
    Inventors: John H. van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20140142104
    Abstract: The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Application
    Filed: November 18, 2013
    Publication date: May 22, 2014
    Inventors: John H. van Duzer, Ralph Mazitschek, Yanbing Ding, Nan Yu, Yun Cao, Yong Liu
  • SELECTIVE HDAC1 AND HDAC2 INHIBITORS
    Publication number: 20140128391
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1 and/or HDAC2. Such diseases include cancer, sickle-cell anemia, beta-thalassemia, and HIV.
    Type: Application
    Filed: November 1, 2013
    Publication date: May 8, 2014
    Inventors: John H. van Duzer, Ralph Mazitschek