Patents by Inventor John H. Wilton

John H. Wilton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CL-1577-B.sub.4 compound, its production and use
    Patent number: 4661353
    Abstract: CL-1577-B.sub.4 compound is derived by the solvolysis under anhydrous conditions of either CL-1577A compound of CL-1577B compound, obtained from the fermentative action of a purified strain of Actinomycete designated ATCC 39363 under aerobic conditions.CL-1577-B.sub.4 compound is a potent antimicrobial agent, possessing activity against a number of gram-positive and gram-negative bacteria, yeasts, and fungi. In addition, the compound exhibits in vivo activity against the P388 murine leukemia cell line and in vitro activity against the L1210 murine leukemia cell line.A method of making the compound as well as pharmaceutical compositions and methods for their use are also disclosed.
    Type: Grant
    Filed: December 4, 1985
    Date of Patent: April 28, 1987
    Assignee: Warner-Lambert Company
    Inventors: John H. Wilton, Gerard C. Hokanson, James C. French
  • Antimicrobial and antitumor phenazine carboxaldehydes and derivatives
    Patent number: 4657909
    Abstract: Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate antimicrobial and antineoplastic activity.A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: April 14, 1987
    Assignee: Warner-Lambert Company
    Inventors: Christopher F. Bigge, Edward F. Elslager, James C. French, Blanche D. Graham, Gerard C. Hokanson, Stephen W. Mamber, Tim A. Smitka, Josefino B. Tunac, John H. Wilton
  • CL-1577-B.sub.4 compound, its production and use
    Patent number: 4594248
    Abstract: CL-1577-B.sub.4 compound is derived by the solvolysis under anhydrous conditions of either CL-1577A compound or CL-1577B compound, obtained from the fermentative action of a purified strain of Actinomycete designated ATCC 39363 under aerobic conditions.CL-1577-B.sub.4 compound is a potent antimicrobial agent, possessing activity against a number of gram-positive and gram-negative bacteria, yeasts, and fungi. In addition, the compound exhibits in vivo activity against the P388 murine leukemia cell line and in vitro activity against the L1210 murine leukemia cell line.A method of making the compound as well as pharmaceutical compositions and methods for their use are also disclosed.
    Type: Grant
    Filed: March 15, 1985
    Date of Patent: June 10, 1986
    Assignee: Warner-Lambert Company
    Inventors: John H. Wilton, Gerard C. Hokanson, James C. French