Patents by Inventor John H. Wolfe
John H. Wolfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150374803Abstract: The present invention provides AAV vectors and methods of use thereof for delivery of transgenes or therapeutic nucleic acids to subjects.Type: ApplicationFiled: September 10, 2015Publication date: December 31, 2015Inventor: John H. Wolfe
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Patent number: 8703733Abstract: Compositions and methods for treating neurological diseases and disorders are disclosed.Type: GrantFiled: May 13, 2011Date of Patent: April 22, 2014Assignee: The Children's Hospital of PhiladelphiaInventors: John H. Wolfe, Carlos Gay-Antaki
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Publication number: 20130317089Abstract: Compositions and methods effective for increasing bladder control are provided.Type: ApplicationFiled: November 10, 2011Publication date: November 28, 2013Inventors: John H. Wolfe, Rita Valentino
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Publication number: 20130143951Abstract: Compositions and methods for treating neurological diseases and disorders are disclosed.Type: ApplicationFiled: May 13, 2011Publication date: June 6, 2013Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIAInventors: John H. Wolfe, Carlos Gay-Antaki
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Patent number: 7402308Abstract: The invention provides a method of delivering a selected DNA sequence to the central nervous system of a mammal by administering to said mammal a neurotropic virus, said virus containing a selected DNA sequence under the control of a promoter which permits expression of the DNA during the latent infectious state of the virus.Type: GrantFiled: February 23, 1995Date of Patent: July 22, 2008Assignees: Trustees of the University of Pennsylvania, The Wistar InstituteInventors: John H. Wolfe, Nigel W. Fraser
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Publication number: 20040214332Abstract: Stable clones of neural stem cells (NSCs) have been isolated from the human fetal telencephalon. In vitro, these self-renewing clones (affirmed by retroviral insertion site) can spontaneously give rise to all 3 fundamental neural cell types (neurons, oligodendrocytes, astrocytes). Following transplantation into germinal zones of the developing newborn mouse brain, they, like their rodent counterparts, can participate in aspects of normal development, including migration along well-established migratory pathways to disseminated CNS regions, differentiation into multiple developmentally- and regionally-appropriate cell types in response to microenvironmental cues, and non-disruptive, non-tumorigenic interspersion with host progenitors and their progeny. Readily genetically engineered prior to transplantation, human NSCs are capable of expressing foreign transgenes in vivo in these disseminated locations.Type: ApplicationFiled: December 15, 2003Publication date: October 28, 2004Applicants: Children's Medical Center Corporation, University of British Columbia, University of PennsylvaniaInventors: Snyder Y. Evan, John H. Wolfe, Seung U. Kim
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Patent number: 6680198Abstract: Stable clones of neural stem cells (NSCs) have been isolated from the human fetal telencephalon. In vitro, these self-renewing clones (affirmed by retroviral insertion site) can spontaneously give rise to all 3 fundamental neural cell types (neurons, oligodendrocytes, astrocytes). Following transplantation into germinal zones of the developing newborn mouse brain, they, like their rodent counterparts, can participate in aspects of normal development, including migration along well-established migratory pathways to disseminated CNS regions, differentiation into multiple developmentally- and regionally-appropriate cell types in response to microenvironmental cues, and non-disruptive, non-tumorigenic interspersion with host progenitors and their progeny. Readily genetically engineered prior to transplantation, human NSCs are capable of expressing foreign transgenes in vivo in these disseminated locations.Type: GrantFiled: September 20, 1999Date of Patent: January 20, 2004Assignees: The Children's Medical Center Corporation, University of British Columbia, University of PennsylvaniaInventors: Evan Y. Snyder, John H. Wolfe, Seung U. Kim
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Patent number: 6541255Abstract: Stable clones of neural stem cells (NSCs) have been isolated from the human fetal telencephalon. In vitro, these self-renewing clones (affirmed by retroviral insertion site) can spontaneously give rise to all 3 fundamental neural cell types (neurons, oligodendrocytes, astrocytes). Following transplantation into germinal zones of the developing newborn mouse brain, they, like their rodent counterparts, can participate in aspects of normal development, including migration along well-established migratory pathways to disseminated CNS regions, differentiation into multiple developmentally- and regionally-appropriate cell types in response to microenvironmental cues, and non-disruptive, non-tumorigenic interspersion with host progenitors and their progeny. Readily genetically engineered prior to transplantation, human NSCs are capable of expressing foreign transgenes in vivo in these disseminated locations.Type: GrantFiled: September 20, 1999Date of Patent: April 1, 2003Assignees: The Children's Medical Center Corporation, The University of British Columbia, The University of PennsylvaniaInventors: Evan Y. Snyder, John H. Wolfe, Seung U. Kim
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Patent number: 6528306Abstract: Stable clones of neural stem cells (NSCs) have been isolated from the human fetal telencephalon. In vitro, these self-renewing clones (affirmed by retroviral insertion site) can spontaneously give rise to all 3 fundamental neural cell types (neurons, oligodendrocytes, astrocytes). Following transplantation into germinal zones of the developing newborn mouse brain, they, like their rodent counterparts, can participate in aspects of normal development, including migration along well-established migratory pathways to disseminated CNS regions, differentiation into multiple developmentally- and regionally-appropriate cell types in response to microenvironmental cues, and non-disruptive, non-tumorigenic interspersion with host progenitors and their progeny. Readily genetically engineered prior to transplantation, human NSCs are capable of expressing foreign transgenes in vivo in these disseminated locations.Type: GrantFiled: September 20, 1999Date of Patent: March 4, 2003Assignees: The Children's of Medical Center Corporation, The University of British Columbia, The University of PennsylvaniaInventors: Evan Y. Snyder, John H. Wolfe, Seung U. Kim
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Patent number: 5958767Abstract: Stable clones of neural stem cells (NSCs) have been isolated from the human fetal telencephalon. In vitro, these self-renewing clones (affirmed by retroviral insertion site) can spontaneously give rise to all 3 fundamental neural cell types (neurons, oligodendrocytes, astrocytes). Following transplantation into germinal zones of the developing newborn mouse brain, they, like their rodent counterparts, can participate in aspects of normal development, including migration along well-established migratory pathways to disseminated CNS regions, differentiation into multiple developmentally- and regionally-appropriate cell types in response to microenvironmental cues, and non-disruptive, non-tumorigenic interspersion with host progenitors and their progeny. Readily genetically engineered prior to transplantation, human NSCs are capable of expressing foreign transgenes in vivo in these disseminated locations.Type: GrantFiled: August 14, 1998Date of Patent: September 28, 1999Assignee: The Children's Medical Center Corp.Inventors: Evan Y. Snyder, John H. Wolfe, Seung U. Kim
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Patent number: 4769122Abstract: An electrochemical cell for use in gas detection includes a cell body having an electrolyte cavity and a separate sensor cavity. The sensor cavity holds stacked sensor elements including a counter electrode, electrolyte mat, reference electrode and sensing electrode. A wick draws the electrolyte from the electrolyte cavity to the electrolyte mat. The sensing electrode closes off the sensor cavity and seals the counter and reference electrodes therein. The only gas which contacts the counter and reference electrodes is that which passes through the sensing electrode or is generated by the counter electrode and becomes dissolved in the electrolyte.Type: GrantFiled: July 10, 1987Date of Patent: September 6, 1988Assignee: Bacharach, Inc.Inventors: Carl A. Marrese, David J. D'Amico, Peter M. Noble, Robert L. Novack, John H. Wolf, Andrew A. Sicree