Patents by Inventor John H. Wyckoff, III

John H. Wyckoff, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for protecting a mammalian host against infection by Brucella
    Patent number: 6264952
    Abstract: Vaccines against facultative intracellular pathogens are disclosed. A host is vaccinated with non-viable but metabolically active agents. The non-viable agents produce immunogenic components that elicit protective host immune responses, with minimal likelihood of host infection by the vaccine agent. Living agents, either attenuated or virulent, are exposed to a dose of gamma irradiation (or other strong mutagen) that is sufficient to limit or prevent the replication of the agents within the host, but that is insufficient to stop the metabolic activities of the agent. In vitro exposure of a microbial agent to the damaging effects of gamma irradiation or of another strong mutagen induces certain stress responses in the infectious agent. These stress responses are similar to the stress responses that the virulent agent would produce within the tissues of the host.
    Type: Grant
    Filed: December 11, 1997
    Date of Patent: July 24, 2001
    Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Virginia Polytechnic Institute and State University, Board of Regents for Oklahoma State University, Cornell Research Foundation, Inc.
    Inventors: Frederick M. Enright, Alexander J. Winter, Gerhardt G. Schurig, John H. Wyckoff, III