Patents by Inventor John Hamman

John Hamman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for activating prothrombin to thrombin
    Patent number: 5677162
    Abstract: The present invention provides a method for activating prothrombin to thrombin in a prothrombin complex composition comprising at least prothrombin, Factors V, VII, IX, and X, and phospholipid, comprising the steps of: (a) cold-incubating the prothrombin complex composition with 2-15 mM of Ca.sup.2+ ions at a pH of 6.5-8.0 and at a temperature of 2.degree.-8.degree. C. until Factor VII contained in the composition is activated; and (b) incubating the cold-incubated composition at a pH of 6.5-8.0 and at a temperature of 10.degree.-25.degree. C. for a period of time sufficient to activate prothrombin contained in the composition to thrombin.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: October 14, 1997
    Assignee: New York Blood Center, Inc.
    Inventors: Jinsheng Zou, John Hamman, Gerard Marx, Bernard Horowitz