Abstract: An expandable pipe for restoring a damaged pipe is provided. The expandable pipe includes a liner formed of thermoplastic polyurethane, and grout material applied to the exterior surface of the liner. The exterior surface includes a plurality of flared tips and grooves, and each groove is located between adjacent flared tips. The grout material is disposed on the flared tips and in the grooves of the liner. The method used to restore the damaged pipe includes clamping the liner with the grout material on a puller-sealer fixture having a U-shaped cross-section to prevent debris from entering the interior of the liner, and pulling the puller-sealer fixture and liner through the damaged pipe. The grout material expands in volume upon exposure to moisture, ultra violet radiation, heat, and/or ultrasonics, and fills cracks or other imperfections and voids along the interior surface of the conduit, caused by corrosion, erosion, or other circumstances.

Abstract: Functional materials and methods for making the functional materials are provided. Also provided are methods for utilizing the functional materials in a variety of applications, including catalysis, adsorption, energy storage, and biomedical applications. The functional materials are made from metal alloys via an oxidative dealloying process that selectively removes one or more elements from the metal alloy and converts one or more of the remaining elements into a stable metal-oxygen matrix having a controlled porosity.

Abstract: A lining system for lining a surface generates a fluid impervious lining and an interstitial space between said lining and said surface. The system includes a layer comprising a flexible material having an adhesive coating on each side thereof, a second layer of flexible material, and a spacing means to generate a gap between the first and second layers, the gap constituting the interstitial space, and a coating, the coating comprising a curable material which cures to form a hard fluid impervious coating.

Abstract: A method (e.g., for monitoring a braking system of a vehicle system) includes monitoring fluid pressures of a braking system and modeled braking efforts of the braking system in a vehicle system traveling along a route, identifying one or more time periods at least one of before a brake event of the braking system or after the brake event, calculating residual forces exerted on the vehicle system during the one or more time periods, and determining at least one of an estimated braking effort of the braking system or an estimated propagation rate at which the estimated braking effort is applied by the braking system using the residual forces that are calculated.

Abstract: Alumina-containing coatings based on molybdenum (Mo), silicon (Si), and boron (B) (“MoSiB coatings”) that form protective, oxidation-resistant scales on ceramic substrate at high temperatures are provided. The protective scales comprise an aluminoborosilicate glass, and may additionally contain molybdenum. Two-stage deposition methods for forming the coatings are also provided.

Abstract: A method (e.g., for monitoring a braking system of a vehicle system) includes monitoring fluid pressures of a braking system and modeled braking efforts of the braking system in a vehicle system traveling along a route, identifying one or more time periods at least one of before a brake event of the braking system or after the brake event, calculating residual forces exerted on the vehicle system during the one or more time periods, and determining at least one of an estimated braking effort of the braking system or an estimated propagation rate at which the estimated braking effort is applied by the braking system using the residual forces that are calculated.

Abstract: Systems, compositions, methods, and kits for identifying potential therapeutic agents for treatment of complement based ocular diseases are provided herein. The methods and kits include a complement component 3 (C3) protein or derivative that is contacted to ocular cells or tissue. Another embodiment of the invention herein provides for diagnosis and/or prognosis of a complement-associated ocular disease. Compositions, methods and kits for regulating or treating a complement-related condition using at least one of CD46 protein, CD55 protein, and a recombinant chimeric soluble terminator of activated complement (STAC) protein or source of the STAC protein. The STAC protein includes an amino acid sequence including at least two of an amino acid sequence of a CD59 protein, an amino acid sequence derived from a CD46 protein, and an amino acid sequence derived from a CD55 protein, optionally further comprising a linker to connect amino acid sequences.

Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: Methods for the low-temperature synthesis of an integrated, corrosion-resistant coating structure for metal substrates by means of multi-component pack cementation are provided. The synthesis of the integrated coating structures at low temperatures can avoid or minimize degradation of the mechanical properties of the substrates. The integrated coating structures can increase the lifetime of high temperature steels under severe steam environments and, therefore, provide a technological enabler for the high-temperature operation of steam power generation plants.

Abstract: A sensor system for measuring a clearance parameter between a stationary component and a rotating component of a rotating machine is provided. The system includes a clearance sensor to output a clearance measurement signal. A sensor memory is attached to the sensor for storing a first sensor information. A second sensor information is stored in a electronics interface memory. The first and the second sensor information are read and the clearance sensor is matched with a respective plurality of calibration data by an electronic interface based on the first and the second sensor information.

Abstract: Alumina-containing coatings based on molybdenum (Mo), silicon (Si), and boron (B) (“MoSiB coatings”) that form protective, oxidation-resistant scales on ceramic substrate at high temperatures are provided. The protective scales comprise an aluminoborosilicate glass, and may additionally contain molybdenum. Two-stage deposition methods for forming the coatings are also provided.

Abstract: A system and a method for detecting a damaged or missing machine part. The system includes an image capturing device for capturing images of the machine and a processor for processing the captured images. The system may further include a sensible output for providing an indication of a damaged or missing machine part. The method includes capturing images of the machine against a background which moves relative to the machine over time, selecting a pair of time-separated images from the captured images, generating a displacement image from the pair of images, comparing the machine from the displacement image with a machine model, and identifying a damaged or missing machine part from the comparison of the displacement image with the machine model. The method may further include providing a sensible output which indicates a damaged or missing machine part.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: Self-calibration of a multiple channel clearance sensor system, which in one embodiment includes at least one sensor for measuring at least one clearance parameter signal between a stationary object and a rotating object of a rotating machine. The sensor output is processed as a clearance parameter by an offset correction section configured to determine an offset error in the clearance parameter signal which is used by a level shifter. The level shifter is also switchably coupled to the clearance parameter signal wherein the output of the level shifter, which may be amplified and digitally converted, is processed by a signal level analyzer to determine a channel gain signal.

Abstract: A method of detecting rubs during operation of a turbomachine comprising at least one rotating object having a tip and a shelf is provided. The method includes generating signals representative of a sensed parameter and processing the signals to generate height versus time data for the tip. The height of the tip corresponds to the distance between the tip and the shelf. The method further includes monitoring the height versus time data, in order to determine whether a change in the height data exceeds a threshold value, and detecting a rub of the rotating object(s) on a second object, when the change in the height data exceeds the threshold value. A rub detection system for a turbomachine and a turbine engine system with rub detection are also provided.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.