Abstract: A blade for use in a gas turbine engine, the blade comprising a blade portion and a fir tree root portion, the blade portion and the root portion having a connected passage for allowing cooling air to flow within the blade, the fir tree root portion having an air intake on its leading edge, the air intake allowing cooling air to enter the cooling passage and wherein the fir tree root portion comprises a plurality of projections, including at least a base projection and a top projection; and wherein the air inlet located in the base projection of the fir tree root portion and wherein the air inlet comprises at least 50% of the face of the base projection of the fir tree root portion.

Abstract: An actuator module includes a base plate extending in a plane, a voice coil connected to the base plate, and a magnet assembly that includes a back side facing the base plate and a front side facing away from the base plate. The magnet assembly includes a base layer and sidewalls defining a cup and an inner element including a center magnet mounted within the cup. The sidewalls include a first and second pair of sidewalls. The actuator module includes a rigid frame attached to the base plate, the rigid frame including four stubs. The actuator module also includes a plurality of springs suspending the magnet assembly relative to the frame and base plate, the plurality of springs including a first spring attached to the frame at a first pair of the four stubs and a second spring attached to the frame at a second pair of the four stubs.

Abstract: Methods and systems that manage building code compliance are provided. A smart or interconnected home may be populated with multiple smart or other devices that are in wired or wireless communication with a central controller. The smart devices may be covered by an insurance policy, such as a homeowners, renters, or personal articles insurance policy. The controller may receive building code compliance information associated with the smart devices, and may update an inventory list to include the building code compliance information. The controller may detect that one or more devices do not comply with building code requirements. The controller may transmit a notification to a customer about possible corrective actions to remedy non-compliant conditions and to facilitate building code compliance. The smart devices may be associated with appliances, electronics, wiring, pipes, ducts, or other equipment or personal belongings.

Abstract: The present invention relates to an intranasal pharmaceutical dosage form comprising a dosing unit comprising naloxone or a pharmaceutically acceptable salt thereof in an amount of equivalent to ?0.5 mg naloxone HCl dissolved in an application fluid of a volume of ?250 ?l. Furthermore, the present invention relates to such an intranasal pharmaceutical dosage form for use in the treatment of opioid overdosing and/or at least one symptom thereof.

Abstract: Aspects of the disclosure relate to a system and method for securely authenticating a device via token(s) and/or verification computing device(s). A verification computing device may generate a pseudorandom number or sequence. Based on the pseudorandom number or sequence, the verification computing device may select a first plurality of parameters associated with a user of a device to be authenticated. The verification computing device may transmit, to the device, the pseudorandom number or sequence, and the device may select a second plurality of parameters. The device may generate a token based on the second plurality of parameters. The device may send the token to another device, and the other device may send the token to the verification computing device. The verification computing device may authenticate the device based on the token.

Abstract: Described herein are TYK2 pseudokinase ligands and methods of utilizing TYK2 pseudokinase ligands in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Abstract: Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

Abstract: Described herein are heterocyclic compounds, compositions, and methods for their use for the treatment of disease.

Abstract: The disclosure generally pertains to systems and methods for providing a vehicle-and-drone-based security service. In an example method, a first area of interest and a second area of interest associated with a structure may be determined. The first area of interest may then be determined to be monitored at the vehicle. The second area of interest may also be determined to be monitored at a drone associated with the vehicle. A route may be identified for the drone to travel along, where the route is configured for the drone to monitor the second area of interest. The drone may then be launched via the vehicle to travel along the route to monitor the second area of interest.

Abstract: Aqueous formulations and kits of radiopharmaceutical compounds of general Formula (II) protected from radiolysis with stabilisers, such as L-methionine and gentisic acid, are disclosed, wherein the compounds are based on sarcophagine ligands coordinated to a radioisotope, such as 64-copper, and linked to a tetrazine group for reaction with tumour targeting antibodies having functional reactive groups such as trans-cyclooctene, processes of preparing said radioligand formulations, and uses thereof for radioimaging, diagnosing and treating cancer.

Abstract: A variety of thermoplastic parts are provided with precise micro-scale features and long-range macro-scale reproducibility. By combining the advantages of rigid tool molding and soft tooling into a hybrid tooling, complex and challenging microfeatures can be created in thermoplastic parts with remarkable positional accuracy and reproducibility. The parts described herein can demonstrate orders of magnitude smaller inter-part variations and order of magnitude smaller variations with respect to a master part as compared to conventional hard and soft tooling methods. In some aspects, a plurality of thermoplastic parts having precision micro-scale features and reproducible macro-scale dimensions are provided wherein the precision micro-scale features on each part comprise at least one challenging microfeature; and wherein a mean normalized displacement of the micro-scale features is about or less when measured between the parts in the plurality of thermoplastic parts.

Abstract: A handheld vacuum device is presented. That handheld vacuum device comprises a housing, a vacuum-generating system, and a hook. The housing has a handle, while the vacuum-generating system is disposed within the housing, and is configured to generate vacuum pressure that creates suction for the handheld vacuum device. The hook is coupled to the housing, and has a bent portion that is configured to engage an external structure for hanging the handheld vacuum device from the external structure.

Abstract: Disclosed herein are particles and methods of using said particles in assays for detection of biomolecules in a sample. Various methods of the present disclosure utilize particles for biomolecule adsorption. In some aspects, the present disclosure provides methods which utilize multiple particle concentrations to differentially fractionate biological samples. In further aspects, the present disclosure provides methods which utilize low particle concentrations to enhance adsorbed biomolecule diversity.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes. A method includes obtaining one or more load cases and one or more design criteria for a modeled object, the one or more design criteria comprising a build material strength model indicating strength relationships between thickness of an object feature and build angle for that object feature resulting from additive manufacturing; iteratively modifying a three dimensional shape of the modeled object in accordance with the one or more design criteria and the one or more load cases, including applying the strength relationships between the thickness of the object feature and the build angle for that object feature on a per-element basis during numerical simulation of the modeled object; and providing the three dimensional shape of the modeled object for use in manufacturing a physical structure.

Abstract: Described herein are TYK2 pseudokinase ligands and methods of utilizing TYK2 pseudokinase ligands in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Abstract: A method of deliquification of production wells includes placing an artificial lift tool in a gas wellbore, where the artificial lift tool includes a rack and multiple piezoelectric transducers. The rack includes multiple trays. Each piezoelectric transducer of the multiple piezoelectric transducers is positioned on a respective tray of the multiple trays. The method further includes providing, by a pump, a liquid on surfaces of the multiple piezoelectric transducers and providing, by a signal source, an electrical signal to the multiple piezoelectric transducers. The method also includes generating, by the multiple piezoelectric transducers, acoustic waves from the electrical signal, where at least some of the liquid provided to the multiple piezoelectric transducers is atomized by the acoustic waves.

Abstract: Described herein are Janus kinase (JAK) inhibitors and methods of utilizing JAK inhibitors in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Abstract: A device for detecting properties of soft tissue. The device comprises a probe coupled to drive means to urge the probe against the soft tissue, a detector for determining applied stress to the soft tissue, and an ultrasonic transmitter configured to, in use, transmit ultrasound waves through at least a portion of the probe and through the soft tissue. A system including the device is also provided along with a corresponding method.

Abstract: A louver position sensing system for a sieve and chaffer of a combine harvester. One system provides that at least one sensor is in actual, physical contact with one or more louvers of the sieve and chaffer. Another system provides that a one or more magnet holders are mounted on louvers and, spaced away, sensors sense magnets in the magnet holders to determine the rotational position of the louvers. Either system allows for accurate, on-the-fly adjustment of the louvers in order to maximize the efficiency of operation of the sieve and chaffer. Preferably, the sensing systems are configured such that sensed position of the louvers is broadcast on the CAN bus of the combine harvester. As a result, the position information can be used to dynamically adjust the openings between the louvers of the sieve and chaffer to achieve more efficient grain cleaning as the machine and field variables change.

Abstract: A simulation suggestion system comprising a server connected with a plurality of clients via a network. The server executes a design engine for generating designs, a simulation suggestion engine for identifying suggested simulations for the designs, and a simulation engine for performing the suggested simulations on the designs. The simulation engine includes one or more simulation tools for performing one or more suggested simulations on a design. A user completes a design of an object via the design engine. The simulation suggestion engine automatically identifies one or more simulation tools that are appropriate for the completed design based on at least one characteristic of the design. The simulation suggestion engine automatically identifies and loads simulation parameters (boundary conditions) for the suggested simulation tools. The suggested simulation tools are then performed on the completed design via the simulation engine.