Abstract: A tensioner comprising a first pivot arm having a first pulley journalled thereto and engagable with a mounting surface through a first pivot axis, a second pivot arm having a second pulley journalled thereto, the second pivot arm pivotally engaged to the first pivot arm through a second pivot axis, the second pivot axis disposed from the first pivot axis, a biasing member engaged between the first pivot arm and the second pivot arm urging the first pulley toward the second pulley, and the second pivot axis is between the first pulley and the first pivot axis.

Abstract: The present invention provides amorphous arid crystalline forms of 1-ethyl-6-(indan-2-ylamino)-3-(morpholine-4-carbonyl)-1,8-naphthyridin-4-one (compound 1), and salts, co-crystals, and pharmaceutical compositions thereof. The invention also provides methods of treating and/or preventing a disease, such as a central nervous system disease (e.g., an anxiety disorder), using the amorphous and crystalline forms, and salts, co-crystals, and pharmaceutical compositions thereof.

Abstract: A variable area fan nozzle assembly for a turbofan engine includes a nacelle having an aft edge and a translating thrust reverser sleeve with a trailing edge. The thrust reverser sleeve is movably disposed aft of the nacelle's aft edge and is movable between a forward position and an aft position. A translating fan nozzle having a forward edge is movably disposed behind the trailing edge, and is movable between a stowed position and a deployed position. An upstream bypass flow exit is defined between the trailing edge and the forward edge when the fan nozzle is in the deployed position. An extendable actuation system is configured to move the fan nozzle between the stowed position and the deployed position.

Abstract: Disclosed is a method in the fields of biochemistry and molecular biology. The method is related to improve cleavage kinetics of labeled oligonucleotide probes and, consequently, increases signal-to-noise ratio in detecting nucleic acids.

Abstract: The process creates a radial temperature gradient in an extruded strand in a direction normal to the direction of motion thereof (that is, normal to the longitudinal direction thereof) so that upon exiting the first quench region the surface of the strand has solidified while at least the preponderant portion of the interior of the strand remains above the cold crystallization temperature, Tcc Then, in the annealing region, heat from the warmer interior will be transferred to the cooler surface, causing the surface to heat up into the range of Tcc, thereby inducing the surface to undergo crystallization. Once the surface has undergone crystallization, the strand is thoroughly quenched in a second quench region so that the strand will be ready for pelletization, accumulation or other handling steps.

Abstract: Various systems and methods for automated air suspension pressure drop are disclosed. In one embodiment, a method for decreasing air pressure in an air spring is provided, comprising: providing a trailer, the trailer comprising: a first axle and a second axle, wherein at least one of the first axle and the second axle is operatively connected to at least one air spring; providing a strain gauge operatively connected to the trailer, wherein the strain gauge is configured to identify a lateral bending strain in the trailer; identifying the presence of the lateral bending strain in the trailer, wherein the lateral bending strain is about an axis substantially normal to the trailer's plane of travel; communicating the presence of the lateral bending strain in the trailer to a control unit operatively connected to the at least one air spring; and decreasing the air pressure in the at least one air spring.

Abstract: Various systems and methods for automated air suspension pressure drop are disclosed. In one embodiment, a method for decreasing air pressure in an air spring is provided, comprising: providing a trailer, the trailer comprising: a first axle and a second axle, wherein at least one of the first axle and the second axle is operatively connected to at least one air spring; providing a strain gauge operatively connected to the trailer, wherein the strain gauge is configured to identify a lateral bending strain in the trailer; identifying the presence of the lateral bending strain in the trailer, wherein the lateral bending strain is about an axis substantially normal to the trailer's plane of travel; communicating the presence of the lateral bending strain in the trailer to a control unit operatively connected to the at least one air spring; and decreasing the air pressure in the at least one air spring.

Abstract: This invention relates to compounds of the formula (I): The invention also relates to processes for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer, as well as the treatment of diseases ameliorated by the control and/or inhibition of lymphangiogenesis.

Abstract: An accessory drive tuning device with a torsion spring for angular vibration isolation and having a spring pocket that frictionally engages the end of the torsion spring. The engagement may be with a wedge-shape on either the spring end or the pocket or both, adapted so that the spring end wedges into the pocket. The engagement may be by interference fit. One or both ends of the spring may be engaged in respective pockets.

Abstract: A crystalline Form B of compound 1 can be used in pharmaceutically compositions. The pharmaceutical compositions can be used in methods of treating a disease (e.g., a disease of the central nervous system).

Abstract: This invention relates to a compound of the formula (I): The invention also relates to processes for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer, as well as the treatment of diseases ameliorated by the control and/or inhibition of lymphangiogenesis.

Abstract: This invention relates to a compound of the formula (I): The invention also relates to processes for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer, as well as the treatment of diseases ameliorated by the control and/or inhibition of lymphangiogenesis.

Abstract: Various systems and methods for automated air suspension pressure drop are disclosed.

Abstract: An orbital tensioner comprising a base, a carrier engaged with the base and revolvable about an axis A-A, a first pulley journalled to the carrier, a pivot arm mounted to the carrier, the pivot arm pivotable about an axis B-B, a second pulley journalled to the pivot arm, the axis B-B is orbitally movable about axis A-A, a spring engaged between the carrier and the pivot arm, and a damping mechanism frictionally engaged between the carrier and the base to damp a carrier movement.

Abstract: The present invention provides methods of synthesizing compounds of formula (1) and intermediates thereto. The present invention also provides intermediates useful in the synthesis of compounds of formula (1).

Abstract: A medical apparatus for analyzing fluid samples includes an outer casing, a slide loading mechanism disposed within the outer casing for loading fluid analysis slides, a slide ejecting mechanism disposed within the outer casing for ejecting fluid analysis slides, an evaporation cap opening mechanism disposed within the outer casing for opening an evaporation cap, an evaporation cap closing mechanism disposed within the outer casing for closing an evaporation cap, a drawer locking mechanism disposed within the outer casing for locking a drawer associated with the outer casing, a camera disposed within the outer casing, and a robot disposed within the outer casing. The robot is movable in three dimensions and has means for conducting three or more of the following operations: slide loading; slide ejecting; evaporation cap opening; evaporation cap closing; drawer locking; and camera manipulation.

Abstract: This invention relates to compounds of the formula (I). The invention also relates to processes for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer as well as the treatment of diseases ameliorated by the control and/or inhibition of lymphanglogenesis.

Abstract: A method of synthesizing copolymers is provided. The method can include coupling a degradable polymer to a poly(amino acid) and then deprotecting the copolymer if the poly(amino acid) contains protected side chains. Copolymer compositions are provided. These compositions include PLGA-PLL copolymers, PLGA-PLL-cbz copolymers, and copolymers of a polyester with a carboxylic acid end group coupled to a poly(amino acid) with an amine group. The compositions may include therapeutic blends and formulations of copolymers.

Abstract: The present invention discloses a method for determining a suitable donor for a recipient in need of transplant based on identifying short tandem repeat allele length differences.

Abstract: The present invention provides compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful in treating central nervous system disorders, such as anxiety disorders or depression.