Abstract: The present disclosure describes various improvements for programmable nuclease-based detection assays. Also provided are compositions, methods, kits, systems, and devices for practicing the same. Such improvements include improved reporter designs to facilitate the cleavage of a reporter immobilized on a substrate by an activated programmable nuclease. Improved reporter designs may comprise various lengths and structures of the reporter. The substrate can also comprise immobilized guide nucleic acids and/or programmable nucleases.

Abstract: Systems and methods for efficiently managing bulk material are provided. The disclosure is directed to a portable support structure used to receive one or more portable containers of bulk material and output bulk material from the containers directly into the blender hopper. The portable support structure may include a frame for receiving and holding the one or more portable bulk material containers in an elevated position proximate the blender hopper, as well as one or more gravity feed outlets for routing the bulk material from the containers directly into the blender hopper. In some embodiments, the portable support structure may be transported to the well site on a trailer, unloaded from the trailer, and positioned proximate the blender unit. In other embodiments, the portable support structure may be a mobile support structure that is integrated into a trailer unit.

Abstract: Non-settling aqueous-based pourable alkaline suspensions may be prepared from mixtures of at least one water soluble amphiphile and at least one oil soluble amphiphile, wherein the amphiphiles have from 6 to 11 carbon atoms in the hydrophobic portion of the amphiphile. The water soluble amphiphiles are classed as hydrotropes, and the oil soluble amphiphile component contains at least one amine group.

Abstract: Systems, media, compositions, methods, and kits disclosed herein relate to a panel of protein biomarkers for the early detection of colon cell proliferative disorders, including colorectal cancer. The presence or levels of the proteins in a biological sample for the protein panels described herein may be used for classifier generation, and as inputs in machine learning models useful to classify subjects in a population for the detection of colon cell proliferative disorders.

Abstract: A method of monitoring a data processing system which is processing a transaction, comprising steps of: receiving event data from each of a plurality of data processing sub-systems making up the data processing system, the event data corresponding to events taking place within the plurality of data processing sub-systems as the data processing system processes the transaction; deriving address information from the event data; mapping the address information to corresponding process status indicator labels; and displaying the process status indicator labels for review by a user.

Abstract: Non-settling aqueous-based pourable suspensions may be prepared from mixtures of water soluble and oil soluble amphiphiles with from 6 to 11 carbon atoms in the hydrophobic portion of the amphiphile. The water soluble amphiphiles are classed as hydrotropes. The systems are low foaming and are particularly useful for suspending problematic materials such as graphene and diamond powder.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.

Abstract: The present embodiments are directed, in part, to 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, such as those of Formula I, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinson's Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: Systems, media, compositions, methods, and kits disclosed herein relate to a panel of protein biomarkers for the early detection of colon cell proliferative disorders, including colorectal cancer. The presence or levels of the proteins in a biological sample for the protein panels described herein may be used for classifier generation, and as inputs in machine learning models useful to classify subjects in a population for the detection of colon cell proliferative disorders.

Abstract: A storage area network architecture and a method for storing data in the storage area network architecture are disclosed. For example, the storage area network architecture comprises a first layer of servers, the first layer of servers comprising a plurality of file receiving servers, a second layer of servers, the second layer of servers comprising a plurality of file sharing servers in communication with the first layer of servers and a third layer of servers, the third layer of servers comprising a plurality of storage servers in communication with the second layer of servers.

Abstract: A computer system may access an attributization rule and convert, based on the attributization rule, profile data into attributes for a robust recipient profile. The system may identify, based on tag logic, tags that are associated with the attributes. The tag logic may include instructions to compare the attributes with predetermined attributes associated with the tags. The system may map the identified tags to the recipient identifier. The system may perform communication with a mobile device based on the robust recipient profile and a real-time location of the mobile device. To perform the communication, the system may monitor the plurality of data channels for data comprising real-time location information for the mobile device. The system may determine the mobile device is proximate to a physical object that is associated with the tag and the system may transmit offer information to the mobile device.

Abstract: A storage area network architecture and a method for storing data in the storage area network architecture are disclosed. For example, the storage area network architecture comprises a first layer of servers, the first layer of servers comprising a plurality of file receiving servers, a second layer of servers, the second layer of servers comprising a plurality of file sharing servers in communication with the first layer of servers and a third layer of servers, the third layer of servers comprising a plurality of storage servers in communication with the second layer of servers.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: A tonneau cover for covering the opening of a cargo bed of a pickup truck. The tonneau cover includes a sandwich panel including a structural core, a first layered section, and a second layered section. The structural core has a top surface and a bottom surface. The first layered section is coupled to the top surface of the structural core, and a second layered section is coupled to the bottom surface of the structural core. Each of the first and second layered sections includes a reinforcement layer, and at least one of the reinforcement layers of the first and second layered sections is a carbon fiber mat. The tonneau cover may have a single panel configuration or a tri-panel configuration.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: A tonneau cover for covering the opening of a cargo bed of a pickup truck. The tonneau cover includes a sandwich panel including a structural core, a first layered section, and a second layered section. The structural core has a top surface and a bottom surface. The first layered section is coupled to the top surface of the structural core, and a second layered section is coupled to the bottom surface of the structural core. Each of the first and second layered sections includes a reinforcement layer, and at least one of the reinforcement layers of the first and second layered sections is a carbon fiber mat. The tonneau cover may have a single panel configuration or a tri-panel configuration.