Abstract: Disclosed are various embodiments for increasing the biotransport characteristics of a psychedelic active ingredient across the mammalian blood-brain barrier. Disclosed are pharmaceutically-acceptable psychedelics that, when administered, convert to an active form in vivo, and act as a 5HT2AR agonist which are useful to treat psychiatric disorders, neurological disorders, degenerative disorders, inflammatory disorders, and symptoms thereof.

Abstract: The present disclosure describes systems and methods for efficient reporting of data which includes personally identifiable information (PII) and which is collected and processed by a security awareness system. The data may be stored in a data storage system. The data may include a time stamp and queries of an historical nature may be supported.

Abstract: An upsell purchase flow in an e-commerce system is provided. After a customer has purchased a product from a vendor, an upsell opportunity is provided to the customer through an upsell pitch page. The upsell pitch page advertises an additional upsell product in order to maximize the purchase transaction with the customer. Responsive to the customer accepting the upsell opportunity, rather than adding the upsell product to an electronic shopping cart, a marketplace server that facilitates transactions between the customer and the vendor charges the customer for the upsell product at that time. Multiple upsell opportunities may be provided to the customer after the initial sale is completed.

Abstract: An upsell purchase flow in an e-commerce system is provided. After a customer has purchased a product from a vendor, an upsell opportunity is provided to the customer through an upsell pitch page. The upsell pitch page advertises an additional upsell product in order to maximize the purchase transaction with the customer. Responsive to the customer accepting the upsell opportunity, rather than adding the upsell product to an electronic shopping cart, a marketplace server that facilitates transactions between the customer and the vendor charges the customer for the upsell product at that time. Multiple upsell opportunities may be provided to the customer after the initial sale is completed.

Abstract: An upsell purchase flow in an e-commerce system is provided. After a customer has purchased a product from a vendor, an upsell opportunity is provided to the customer through an upsell pitch page. The upsell pitch page advertises an additional upsell product in order to maximize the purchase transaction with the customer. Responsive to the customer accepting the upsell opportunity, rather than adding the upsell product to an electronic shopping cart, a marketplace server that facilitates transactions between the customer and the vendor charges the customer for the upsell product at that time. Multiple upsell opportunities may be provided to the customer after the initial sale is completed.

Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.

Abstract: There are disclosed methods and apparatus for monitoring hydraulic fracturing operations, using a distributed optical fibre sensor to detect relevant acoustic signatures, such as acoustic signatures of cement washout and of events involving a valve drive component.

Abstract: Gas fired internal combustion engines which are run on contaminated fuel suffer from the buildup of internal deposits and corrosion. This is a particular problem with engines fuelled by biogas, e.g. from waste decomposition. By filtering the fuel via a filter containing an ion-exchange resin substantial improvements can be obtained.

Abstract: An upsell purchase flow in an e-commerce system is provided. After a customer has purchased a product from a vendor, an upsell opportunity is provided to the customer through an upsell pitch page. The upsell pitch page advertises an additional upsell product in order to maximize the purchase transaction with the customer. Responsive to the customer accepting the upsell opportunity, rather than adding the upsell product to an electronic shopping cart, a marketplace server that facilitates transactions between the customer and the vendor charges the customer for the upsell product at that time. Multiple upsell opportunities may be provided to the customer after the initial sale is completed.

Abstract: Gas fired internal combustion engines which are run on contaminated fuel suffer from the buildup of internal deposits and corrosion. This is a particular problem with engines fuelled by biogas, e.g. from waste decomposition. By filtering the fuel via a filter containing an ion-exchange resin substantial improvements can be obtained.

Abstract: A thermostatic mixing valve having a hot water inlet for connection to a supply of hot water, a cold water inlet for connection to a supply of cold water, an outlet for temperature controlled water and a valve device for controlling the relative proportions of hot and cold water admitted to a mixing chamber. The outlet communicates with the mixing chamber to receive temperature controlled water having a desired temperature. A temperature control adjusts the valve device in accordance with the desired temperature of the temperature controlled water where the valve device and the mixing chamber form flow passages for the incoming streams of hot and cold water and are configured such that the velocity of the incoming water streams is maintained and the incoming water streams are turned to flow in the same direction so that flow of one stream can entrain and assist flow of the other stream.

Abstract: A thermostatic mixing valve for hot and cold water has two-stage inlet chambers for the hot and cold water flows respectively. The inlet chambers distribute the flows uniformly with respect to porting for admitting the flows to the mixing chamber to reduce asymmetric flow patterns and promote thorough mixing of the flows within the mixing chamber.

Abstract: A method is provided for distinguishing a valid locomotive control signal from an invalid control signal resulting from the presence of at least one interfering signal. The method includes detecting a signal, and transforming the signal into the frequency domain to create a transformed signal having a number of frequency domain peaks. The validity of the signal is determined based on at least of a number, a spacing, and a magnitude of the frequency domain peaks in the transformed signal.

Abstract: A circuit board (PCB) and connector design, which provides for better electrical connection between the PCB and its host, especially for when used in high-speed optical systems. The PCB has an electrical flex embedded within it. The flex is connected to electrical component located on the PCB by means of a via at one end and protrudes from the PCB at the other end. The connector has a flex connection means arranged to receive the flex protruding from the PCB.

Abstract: A sensor assembly for determining rotational angular displacement of a first moving component in a machine relative to a second component in the machine includes a base, a magnet housing, and a flexible member. The base is configured to be rigidly secured to the first moving component for movement therewith. The base defines a first axis of rotation. The magnet housing supports a sensor magnet and is rotatably received in the second component. The magnet housing defines a second axis of rotation. The flexible member has a first end rigidly secured to the magnet housing coaxially with the first axis of rotation. A second end of the flexible member is rigidly secured to the magnet housing coaxially with the second axis of rotation. A flexible body portion of the flexible member is capable of accommodating misalignment between the first and second axes of rotation.

Abstract: A thermostatic mixing valve for hot and cold water has two-stage inlet chambers for the hot and cold water flows respectively. The inlet chambers distribute the flows uniformly with respect to porting for admitting the flows to the mixing chamber to reduce asymmetric flow patterns and promote thorough mixing of the flows within the mixing chamber.

Abstract: A clutch assembly that includes an input member rotatable about an axis, an output member rotatable about the axis, and an engagement member having a portion between the input and output members. The engagement member is operable to selectively couple the input and output members together for co-rotation. The clutch assembly further includes a blocking member having a base and a projection. The projection is coupled to the engagement member to substantially prevent the engagement member from coupling the input and output members together for co-rotation when the input member rotates in a first direction relative to the output member, while allowing the engagement member to couple the input and output members lor together co-rotation when the input member rotates in a second direction relative to the output member.

Abstract: A roller bearing assembly (10) comprising radially inner and outer bearing races (20, 30) with a plurality of roller bearings (40) positioned therebetween. A first plurality of gear teeth (52) are provided in the outer bearing race (20). A second plurality of gear teeth (52) are provided in the inner bearing race (30) in alignment with the first plurality of gear teeth (52).

Abstract: A rocker arm assembly for mounting about a stud means. The rocker arm assembly generally comprises a rocker arm and a support member. The rocker arm has opposed first and second lateral ends and a central bore between the ends. The support member is positioned within the rocker arm central bore and mounted on the stud means. The rocker arm is configured to pivot about the support member. The support member has opposed lateral sides with a seal member extending along each lateral side. The seal members provide a seal between each lateral side of the support member and an internal surface of the central bore thereby providing more efficient oil lubrication to the ends of the rocker arm.

Abstract: A chain tensioner comprising a support member configured to support a stop bar for axial movement. A ratchet engages the support bar and is configured to permit axial movement of the stop bar in a first direction and prevent axial movement of the stop bar in a second, opposite direction. A shuttle assembly including a tensioning wheel is interconnected to the stop bar such that the shuttle assembly is axially moveable relative to the stop bar over a limited range of motion. A biasing member is configured to bias the shuttle assembly in the second direction.