Abstract: Methods and uses of Rilpivirine and analogues thereof in the treatment and/or prevention of proliferative cell diseases and conditions are disclosed. Among the diseases and conditions that may be treated and/or prevented, are cancers characterised by Aurora A dysregulation.

Abstract: A pressure relief valve is disclosed with a first stage valve that is in series with a second stage valve, with an enclosed cavity between the first stage valve and the second stage valve. The first stage valve relieves pressure from an enclosure into the enclosed cavity between the stages, when the pressure is above a cracking pressure of the first stage valve. The second stage relieves pressure from the enclosed cavity when the pressure is above the cracking pressure of the second stage valve.

Abstract: A pressure relief valve is disclosed with a first stage valve that is in series with a second stage valve, with an enclosed cavity between the first stage valve and the second stage valve. The first stage valve relieves pressure from an enclosure into the enclosed cavity between the stages, when the pressure is above a cracking pressure of the first stage valve. The second stage relieves pressure from the enclosed cavity when the pressure is above the cracking pressure of the second stage valve.

Abstract: A pressure relief valve is disclosed with a first stage valve that is in series with a second stage valve, with an enclosed cavity between the first stage valve and the second stage valve. The first stage valve relieves pressure from an enclosure into the enclosed cavity between the stages, when the pressure is above a cracking pressure of the first stage valve. The second stage relieves pressure from the enclosed cavity when the pressure is above the cracking pressure of the second stage valve.

Abstract: A pressure relief valve is disclosed with a first stage valve that is in series with a second stage valve, with an enclosed cavity between the first stage valve and the second stage valve. The first stage valve relieves pressure from an enclosure into the enclosed cavity between the stages, when the pressure is above a cracking pressure of the first stage valve. The second stage relieves pressure from the enclosed cavity when the pressure is above the cracking pressure of the second stage valve.

Abstract: An electrode assembly for a myoelectric prosthesis allowing at least partial decoupling of the movement of the at least one electrode from the electrode housing case and from the prosthesis socket through the mounting of the at least one electrode using at least one biasing element. This allows the at least one electrode to be forced into contact with the patient in the target area using a moveable pressure application structure reducing/eliminating socket motion artifacts because the pressure is transferred toward the target area but the at least one electrode is not otherwise constrained to minimise or avoid the at least one electrode being dragged across the target area through the mounting to the prosthesis socket which causes socket motion artifacts.

Abstract: A start system for an expendable gas turbine engine is provided. The start system may include: a tank configured to store a pressurized gas comprising oxygen; a non-pyrotechnic igniter in communication with a combustion chamber of the expendable gas turbine engine; a starter tube configured to feed the pressurized gas from the tank into the combustion chamber; and a valve configured to regulate a flow of the pressurized gas from the tank into the starter tube; wherein, the start system is configured to startup the expendable gas turbine engine by the flow of the pressurized gas from the tank, through the valve and the starter tube, into the combustion chamber and, from the combustion chamber, into a plurality of turbine blades of the expendable gas turbine engine, and by ignition, by the non-pyrotechnic igniter, of fuel injected into the combustion chamber.

Abstract: A device for detecting a being left within a vehicle includes a sensor that detects when a being (e.g. a pet, a child, etc.) is within a vehicle and the operator of the vehicle has moved away from the vehicle by more than, for example five feet. Upon detection of such, the device emits a sound to notify others nearby of the being that was left within the vehicle. The sound is preferably different than a sound of a typical vehicle theft alarm system. In a preferred embodiment, determination that the operator has left the vehicle is by a loss of a signal from a personal transmitter that is attached to the operator's key ring or worn by the operator. After moving away from the vehicle by more than five feet, the signal from the personal transmitter decreases and initiates determination if a being remains within the vehicle.

Abstract: A pressure relief valve is disclosed with a first stage valve that is in series with a second stage valve, with an enclosed cavity between the first stage valve and the second stage valve. The first stage valve relieves pressure from an enclosure into the enclosed cavity between the stages, when the pressure is above a cracking pressure of the first stage valve. The second stage relieves pressure from the enclosed cavity when the pressure is above the cracking pressure of the second stage valve.

Abstract: A device for detecting a being left within a vehicle includes a sensor that detects when a being (e.g. a pet, a child, etc.) is within a vehicle and the operator of the vehicle has moved away from the vehicle by more than, for example five feet. Upon detection of such, the device emits a sound to notify others nearby of the being that was left within the vehicle. The sound is preferably different than a sound of a typical vehicle theft alarm system. In a preferred embodiment, determination that the operator has left the vehicle is by a loss of a signal from a personal transmitter that is attached to the operator's key ring or worn by the operator. After moving away from the vehicle by more than five feet, the signal from the personal transmitter decreases and initiates determination if a being remains within the vehicle.

Abstract: A subsea vessel includes an outer layer of non-corrosive material and an inner layer of high-strength material that both corroborate in a subsea environment to withstand external pressure and prevent corrosion. The subsea vessel further includes a cavity surrounded by the inner layer and outer layer for providing storage in and protection from the subsea environment. The cavity is accessible via an opening that extends through the inner layer and the outer layer. The opening can be opened and closed with a cooperating cap that impermeably seals the cavity. The cap may include a number or connection mechanisms for being selectively secured to the opening. In addition, the cap may include a portion formed of a high-strength material and a portion formed of a non-corrosive material.

Abstract: A device for detecting a being left within a vehicle includes a sensor that detects when a being (e.g. a pet, a child, etc.) is within a vehicle and the operator of the vehicle has moved away from the vehicle by more than, for example five feet. Upon detection of such, the device emits a sound to notify others nearby of the being that was left within the vehicle. The sound is preferably different than a sound of a typical vehicle theft alarm system. In a preferred embodiment, determination that the operator has left the vehicle is by a loss of a signal from a personal transmitter that is attached to the operator's key ring or worn by the operator. After moving away from the vehicle by more than five feet, the signal from the personal transmitter decreases and initiates determination if a being remains within the vehicle.

Abstract: A device for detecting a being left within a vehicle includes a sensor that detects when a being (e.g. a pet, a child, etc.) is within a vehicle and the operator of the vehicle has moved away from the vehicle by more than, for example five feet. Upon detection of such, the device emits a sound to notify others nearby of the being that was left within the vehicle. The sound is preferably different than a sound of a typical vehicle theft alarm system. In a preferred embodiment, determination that the operator has left the vehicle is by a loss of a signal from a personal transmitter that is attached to the operator's key ring or worn by the operator. After moving away from the vehicle by more than five feet, the signal from the personal transmitter decreases and initiates determination if a being remains within the vehicle.

Abstract: A pressure relief valve is disclosed with a first stage valve that is in series with a second stage valve, with an enclosed cavity between the first stage valve and the second stage valve. The first stage valve relieves pressure from an enclosure into the enclosed cavity between the stages, when the pressure is above a cracking pressure of the first stage valve. The second stage relieves pressure from the enclosed cavity when the pressure is above the cracking pressure of the second stage valve.

Abstract: A pressure relief valve is disclosed with a first stage valve that is in series with a second stage valve, with an enclosed cavity between the first stage valve and the second stage valve. The first stage valve relieves pressure from an enclosure into the enclosed cavity between the stages, when the pressure is above a cracking pressure of the first stage valve. The second stage relieves pressure from the enclosed cavity when the pressure is above the cracking pressure of the second stage valve.

Abstract: An installation and removal system for a toilet unit is provided. The system includes a base having floor engaging wheels coupled thereto. At least one of the floor engaging wheels is adjustable to maintain the base substantially level relative to the floor. An actuator is disposed on the base. A pair of spaced apart support elements are coupled to the actuator and adapted to engage an underside of the toilet unit. An angle of the support elements relative the base is adjustable. The system includes a retaining system coupled to the spaced apart support elements and adapted to couple with the toilet unit. The retaining system militate against an undesired movement of the toilet unit relative the support elements. A kit and method for using the system are also provided.

Abstract: An installation and removal system for a toilet unit is provided. The system includes a base having floor engaging wheels coupled thereto. At least one of the floor engaging wheels is adjustable to maintain the base substantially level relative to the floor. An actuator is disposed on the base. A pair of spaced apart support elements are coupled to the actuator and adapted to engage an underside of the toilet unit. An angle of the support elements relative the base is adjustable. The system includes a retaining system coupled to the spaced apart support elements and adapted to couple with the toilet unit. The retaining system militate against an undesired movement of the toilet unit relative the support elements. A kit and method for using the system are also provided.

Abstract: There is provided a method of isolating foetal cells from an isolated sample of maternal blood, the method comprising identifying cells having a different expression pattern of at least one foetal marker compared to the expression pattern of the marker in an equivalent maternal cell and selecting the identified cells, characterised in that the foetal marker is selected from: HSP-60, a monoamine oxidase, glutamine synthase, Ara-70, Ara-54, FLJ20202, DCN-I protein, RAB5A, HSP-7C, EF1A1, GRP78, MYL4, DnaJ homolog subfamily B member 14, Vinculin, Desmoplakin, AMMECR1-like protein, Extracellular matrix protein 2 precursor protein, uncharacterised protein Cxorf57, Peroxiredoxin 1, Peroxiredoxin 2. There is also provided a method of cultivating foetal cells and a foetal cell isolation kit.

Abstract: An installation and removal system for a toilet unit is provided. The system includes a base having floor engaging wheels coupled thereto. At least one of the floor engaging wheels is adjustable to maintain the base substantially level relative to the floor. An actuator is disposed on the base. A pair of spaced apart support elements are coupled to the actuator and adapted to engage an underside of the toilet unit. An angle of the support elements relative the base is adjustable. The system includes a retaining system coupled to the spaced apart support elements and adapted to couple with the toilet unit. The retaining system militate against an undesired movement of the toilet unit relative the support elements. A kit and method for using the system are also provided.

Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a group Ar1L2Ar2Alk- in which: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a covalent bond or a linker atom or group; Ar2 is an optionally substituted arylene or heteroarylene group; and Alk is a chain in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; X is an —O— or —S— atom or —N(R2)— group in which: Rx, Ry and Rz which may be the same or different is each a hydrogen atom or an optional substituent; or Rz is an atom or group as previously defined and Rx and Ry are joined together to form an optionally substituted spiro linked cycloaliphatic or heterocycloaliphatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.