Abstract: This disclosure concerns a system with scattering analysis including a handling system that presents a single particle to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle. A mid-infrared detection facility detects the mid-infrared wavelength light scattered by the single particle, wherein a wavelength and angle analysis of the scattered mid-IR wavelength light is used to determine analyte-specific structural and concentration information.

Abstract: A widely tunable laser is described where a compound semiconductor gain chip is coupled to a waveguide filter fabricated on silicon. The filter has two resonators with different free-spectral-ranges, such that Vernier tuning between the filters can be used to provide a single wavelength of light feedback into the gain chip, where the wavelength is adjustable over a wide range. The coupling between the gain chip and the filter is realized through a microlens whose position can be adjusted using micromechanics and locked in place.

Abstract: This disclosure concerns a cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source configured to deliver light to a cell within the cells in order to induce resonant mid-infrared absorption by one or more analytes of the cell. The system includes a laser source that excites at least one fluorophore present in the cell or on the surface of the cell and a fluorescence detector that measures the fluorescence intensity of the fluorophore. A mid-infrared detection facility detects the transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light and the fluorescence intensity are used to identify at least one cell characteristic.

Abstract: In embodiments of the present invention, a system and method of cytometry may include presenting a single sperm cell to at least one laser source configured to deliver light to the sperm cell in order to induce bond vibrations in the sperm cell DNA, and detecting the signature of the bond vibrations. The bond vibration signature is used to calculate a DNA content carried by the sperm cell which is used to identify the sperm cell as carrying an X-chromosome or Y-chromosome. Another system and method may include flowing cells past at least one QCL source one-by-one using a fluid handling system, delivering QCL light to a single cell to induce resonant mid-IR absorption by one or more analytes of the cell, and detecting, using a mid-infrared detection facility, the transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light is used to identify a cell characteristic.

Abstract: Multiple broad area lasers are coupled to a planar lightwave circuit, where the waveguides come together to form a single wide emitting aperture. A tapered lens is used at the output of the planar lightwave circuit to transform the highly asymmetric mode into a conventional round mode. This configuration allows much higher “brightness”, allowing 10 or more 100 um wide broad area lasers to be coupled into a single 100 um core multimode fiber. This is considerably more efficient than the standard method of combining a single 100 um wide broad area laser to a 100 um core multimode fiber.

Abstract: A spectroscopy system comprising at least two laser modules, each of the laser modules including a laser cavity, a quantum cascade gain chip for amplifying light within the laser cavity, and a tuning element for controlling a wavelength of light generated by the modules. Combining optics are used to combine the light generated by the at least two laser modules into a single beam and a sample detector detects the single beam returning from a sample.

Abstract: An optical assembly includes a combination of laser sources emitting radiation, focused by a combination of lenses into optical waveguides. The optical waveguide and the laser source are permanently attached to a common carrier, while at least one of the lenses is attached to a holder that is an integral part of the carrier, but is free to move initially. Micromechanical techniques are used to adjust the position of the lens and holder, and then fix the holder it into place permanently using integrated heaters with solder.

Abstract: An apparatus and method for acquiring and analyzing a spectroscopic sample for a substance from a sampling region of the tissue of a person at an interstitial region between the fingers of the person, by way of a probe and a spectroscopic detector for radiating the interstitial region with electromagnetic radiation and analyzing a diffuse-reflectance signal obtained from the tissue at the sampling region. The apparatus preferably also incorporates a biometric sensor to perform a verification of the person.

Abstract: A system and method for optical lymph node mapping. The system is useful for guiding sentinel lymph node biopsy surgeries. A contrast agent that includes a fluorescent dye is injected near the site of a malignancy. The contrast agent drains into the lymphatic system, collecting in a sentinel node or nodes. The system utilizes one or more low-power continuous-wave lasers or light-emitting diodes modulated with a digital code sequence to probe the tissue suspected of containing the sentinel node. When the light is incident near the sentinel node, it will excite fluorescence from the dye. A portion of the scattered fluorescent light is captured with one or more photo-detectors. A correlation of the photo-detector signal and the digital code sequence is calculated to produce an estimate of the distribution of flight times for photons traveling from a given source to a given detector.

Abstract: A system and method for measuring photons utilizing a low-power light source modulated with a code sequence to interrogate a sample of interest. Preferably a portion of the scattered light from the sample is detected by a photo-detector. A correlation of the photo-detector signal and the code sequence produces an estimate of the distribution of flight times for photons traveling from the source to the detector.

Abstract: A system and method for measuring fluorescence lifetimes utilizing a light source modulated with a code sequence to interrogate a sample of interest. The system is useful for studying the interaction of chemicals, biomolecules, and other substances. The system utilizes a low-power continuous-wave laser or light-emitting diode modulated with a digital code sequence to interrogate a sample of interest. A portion of the fluorescence light from the sample is captured with a photo-detector. A correlation of the photo-detector signal and the digital code sequence is calculated to produce an estimate of the time-response of the system. The fluorescence lifetime is extrapolated from the correlation data. The fluorescence lifetime is used as an indicator of chemical binding and chemical environment.

Abstract: An optical communication system for transmitting multiple optical beams, each at a different wavelength is disclosed. The optical communication system includes a laser array having multiple laser transmitters transmitting multiple optical beams, each at a different wavelength. The optical communication system further includes a diffraction grating optically coupled to the laser array, the diffraction grating diffracting each of the optical beams at a substantially equal diffraction angle to form a combined optical beam. The combined beam is then focused into an optical communication media.

Abstract: A photonic device including an array of lasers providing light to an array of electro-absorption modulators, both on a common substrate. In some embodiments the lasers are in a closely spaced array and lase at different wavelengths, providing with associated electro-absorption modulators a compact wavelength selectable laser.

Abstract: A semiconductor laser capable of emitting in any one of standard communication wavelengths is of great practical value. To this end, a single semiconductor chip is fabricated on which many different distributed feedback (DFB) lasers are integrated. The device parameters of the different DFB lasers are varied such that each laser emits at a different wavelength. In addition a micro-mechanical optical element is packaged with the laser array, such that the position of the optical element controls which laser stripe is coupled to the output fiber. The micro-mechanical element or switch in various embodiments is a sliding waveguide, a movable lens, or a mirror that tilts. By selecting the particular DFB laser, controlling the temperature to fine tune the wavelength, and adjusting the position of the micro-mechanical optical element, the output wavelength is set to one of many communication wavelengths.

Abstract: An optical communication system for transmitting multiple optical beams, each at a different wavelength is disclosed. The optical communication system includes a laser array having multiple laser transmitters transmitting multiple optical beams, each at a different wavelength. The optical communication system further includes a diffraction grating optically coupled to the laser array, the diffraction grating diffracting each of the optical beams at a substantially equal diffraction angle to form a combined optical beam. The combined beam is then focused into an optical communication media.

Abstract: Described is an optical cross-connect switch having substantially reduced polarization dependent loss in comparison to conventional optical cross-connect switches. The switch includes a first mirror array and a second mirror array defining a first array plane and a second array plane, respectively. The first mirror array reflects an array of optical beams received along a first optical axis to be substantially parallel to a second axis. The first array plane defines a pair of axes orthogonal to each of the first and second optical axes. One of the pair of axes is parallel to the first array plane. The second mirror array is positioned to receive the array of optical beams after reflection from the first mirror array such that the other of the pair of axes is parallel to the second array plane.

Abstract: Described is an optical cross-connect switch having substantially reduced polarization dependent loss in comparison to conventional optical cross-connect switches. The switch includes a first mirror array and a second mirror array defining a first array plane and a second array plane, respectively. The first mirror array reflects an array of optical beams received along a first optical axis to be substantially parallel to a second axis. The first array plane defines a pair of axes orthogonal to each of the first and second optical axes. One of the pair of axes is parallel to the first array plane. The second mirror array is positioned to receive the array of optical beams after reflection from the first mirror array such that the other of the pair of axes is parallel to the second array plane.

Abstract: An optical communication system for transmitting multiple optical beams, each at a different wavelength is disclosed. The optical communication system includes a laser array having multiple laser transmitters transmitting multiple optical beams, each at a different wavelength. The optical communication system further includes a diffraction grating optically coupled to the laser array, the diffraction grating diffracting each of the optical beams at a substantially equal diffraction angle to form a combined optical beam. The combined beam is then focused into an optical communication media.

Abstract: A photonic device including an array of lasers providing light to an array of electro-absorption modulators, both on a common substrate. In some embodiments the lasers are in a closely spaced array and lase at different wavelengths, providing with associated electro-absorption modulators a compact wavelength selectable laser.

Abstract: A semiconductor laser capable of emitting in any one of standard communication wavelengths is of great practical value. To this end, a single semiconductor chip is fabricated on which many different distributed feedback (DFB) lasers are integrated. The device parameters of the different DFB lasers are varied such that each laser emits at a different wavelength. In addition a micro-mechanical optical element is packaged with the laser array, such that the position of the optical element controls which laser stripe is coupled to the output fiber. The micro-mechanical element or switch in various embodiments is a sliding waveguide, a movable lens, or a mirror that tilts. By selecting the particular DFB laser, controlling the temperature to fine tune the wavelength, and adjusting the position of the micro-mechanical optical element, the output wavelength is set to one of many communication wavelengths.