Abstract: Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci in cells and increasing expression of fetal hemoglobin.

Abstract: Methods related to producing a fermented plant-based food product comprising high protein content.

Abstract: The present invention relates to the use of extrusion technology in a process for the low-moisture continuous gelatinisation and the enzymatic hydrolysis of flour to provide a dextrinised product having a dextrose equivalent (DE) of at least 15 and to a process for drying a dextrinised product.

Abstract: A deployable leg rest assembly (3) for mounting to a seat pan (9) of a vehicle seat frame (11) comprises a leg support (4), a mounting plate (13) and a deployment mechanism (6) for deploying the leg support (4). The deployment mechanism (6) connects the leg support (4) to the mounting plate (13). The mounting plate (13) is adapted to be located above the seat pan (9). The deployable leg rest assembly (3) can be mounted to different vehicle seats (1) by accessing the seat pans (9) of the corresponding vehicle seat frames (11).

Abstract: A deployable leg rest assembly (3) for mounting to a seat pan (9) of a vehicle seat frame (11) comprises a leg support (4), a mounting plate (13) and a deployment mechanism (6) for deploying the leg support (4). The deployment mechanism (6) connects the leg support (4) to the mounting plate (13). The mounting plate (13) is adapted to be located above the seat pan (9). The deployable leg rest assembly (3) can be mounted to different vehicle seats (1) by accessing the seat pans (9) of the corresponding vehicle seat frames (11).

Abstract: An apparatus (20) forms a latent indicium onto a sensitized medium, using an area energy source (26) for applying a substantially uniform sensitizing energy over an area of the sensitized medium and a pixel exposure source (30) for applying radiant energy to expose a pattern of pixels (14) onto the area of the sensitized medium for forming the indicium.

Abstract: Two unique instructions for the instruction set of a target 36-bit machine which is emulated on a host 64-bit machine are provided in order to achieve visibility, to an emulated application program, of a “containing” word stored in the memory of the host machine. A “LOAD64” instruction loads the emulator memory location representing an emulated “Q” (supplementary accumulator) register with the “normal” 36-bits of the containing word. At the same time, the “upper” 28 bits of the 64-bit containing word is copied into the emulator memory location representing an emulated “A” (accumulator) register. Thus, the emulated 36-bit machine “sees” and can examine the 64-bit word in its entirety. A “Store64” instruction stores the emulated “Q” register contents into the lower 36-bits of the 64-bit containing word, and at the same time stores the lower 28 bits of the emulated “A” register contents into the upper 28 bits of the 64-bit containing word.

Abstract: Two unique instructions for the instruction set of a target 36-bit machine which is emulated on a host 64-bit machine are provided in order to achieve visibility, to an emulated application program, of a “containing” word stored in the memory of the host machine. A “LOAD64” instruction loads the emulator memory location representing an emulated “Q” (supplementary accumulator) register with the “normal” 36-bits of the containing word. At the same time, the “upper” 28 bits of the 64-bit containing word is copied into the emulator memory location representing an emulated “A” (accumulator) register. Thus, the emulated 36-bit machine “sees” and can examine the 64-bit word in its entirety. A “Store64” instruction stores the emulated “Q” register contents into the lower 36-bits of the 64-bit containing word, and at the same time stores the lower 28 bits of the emulated “A” register contents into the upper 28 bits of the 64-bit containing word.

Abstract: A process for sorting large files or structures is disclosed where improved performance is achieved by reducing the work involved and the time required to do record key comparisons. The reduction is achieved by transposing and saving the key data from each record into a representative form that can be more quickly compared each time the key comparison is required. In addition the process uses pointers to avoid the processing time to exchange records larger than one word in memory. The representation of the key data is optimized and aligned for comparison by word based computer instructions which are typically faster than byte based instructions. The process is optimized for word sizes and instructions which handle words larger than four bytes and in particular for machines and instructions with 64-bit or larger word sizes such as the Intel Itanium series processors.

Abstract: Two unique instructions for the instruction set of a target 36-bit machine which is emulated on a host 64-bit machine are provided in order to achieve visibility, to an emulated application program, of a “containing” word stored in the memory of the host machine. A “LOAD64” instruction loads the emulator memory location representing an emulated “Q” (supplementary accumulator) register with the “normal” 36-bits of the containing word. At the same time, the “upper” 28 bits of the 64-bit containing word is copied into the emulator memory location representing an emulated “A” (accumulator) register. Thus, the emulated 36-bit machine “sees” and can examine the 64-bit word in its entirety. A “Store64” instruction stores the emulated “Q” register contents into the lower 36-bits of the 64-bit containing word, and at the same time stores the lower 28 bits of the emulated “A” register contents into the upper 28 bits of the 64-bit containing word.

Abstract: An apparatus (20) forms a latent indicium onto a sensitized medium, using an area energy source (26) for applying a substantially uniform sensitizing energy over an area of the sensitized medium and a pixel exposure source (30) for applying radiant energy to expose a pattern of pixels (14) onto the area of the sensitized medium for forming the indicium.

Abstract: The present provides structurally related enzymes that act as enoyl reductases. These enoyl reductases share a common amino acid consensus sequence, and bind a flavin cofactor. One particular enoyl reductase provided, FabK, catalyzes the identical reaction as the NADH-dependent enoyl-ACP reductase, FabI. Nucleic acids encoding the enoyl reductases, the enoyl reductases, and anitbodies for the enoyl reductases are also included. Methods are also provides for identifying agents that can act to prevent and/or treat bacterial infections.

Abstract: A centering and loading apparatus for locating the center of a fill opening of a vehicle and loading bulk material into the vehicle through the opening is provided which includes a movable loading spout assembly and a locator assembly which locates the fill opening of the vehicle and is adapted to move the loading spout assembly for centering over the fill opening of the vehicle. The loading spout assembly is supported on a first support and is adapted to move along the longitudinal and lateral horizontal axes of the first support for aligning the loading spout assembly over the fill opening of the vehicle. The locator assembly includes a pair of scanning devices, for example, charge coupled devices, radio frequency sensors, and laser and infrared devices, that detect and scan the fill opening to locate the center of the opening.

Abstract: A hitch structure is arranged for securement in a stable relationship of a trailer in mounting the trailer and associated cargo to a horizontal support post to impart stability to the trailer organization during transport thereof.

Abstract: A permanently installed speed bump or warning device for motorists is particulary adaptable for usage at school crossings and the like. The structure has an active use position above the road surface for deterring and warning drivers and is easily retractable to a nested position wherein a flat surface flush with the roadway is provided so as to allow the smooth passage of vehicles over the device. A convenience tool is provided for moving the device from its active to its inactive positions, and vice-versa.

Abstract: In a supported catalyst for treating internal combustion engine exhaust gases the active material comprises a non-noble metal or compound thereof and the support comprises a primary support carrying a secondary support; the secondary support consists essentially of one or more involatile acidic and/or amphoteric oxides substantially in combination with one or more basic oxides from Group II, III or IV of the Periodic Table. A platinum group metal may also be present. The catalyst can be used for reductive or oxidative treatment or for simultaneous reduction of nitrogen oxides and oxidation of carbon monoxide and hydrocarbons and exhibits high activity and long life.